Pathology Tables for Peer Review
The National Toxicology Program
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
BARIUM CHLORIDE DIHYDRATE
NTP Experiment-Test: 05127-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
Facility: TSI Mason Research
Chemical CAS #: 10326279
Lock Date: 11/15/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 7 10 6
Early Deaths
Moribund 9 11 9 35
Dead 3 5 5 6
Survivors
Terminal Sacrifice 37 37 36 13
Dead 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (54) (55) (56) (54)
Intestine Large, Colon (57) (58) (58) (57)
Intestine Large, Rectum (58) (59) (59) (60)
Intestine Large, Cecum (58) (58) (57) (55)
Leiomyoma 2 (3%)
Intestine Small, Duodenum (57) (57) (58) (54)
Intestine Small, Jejunum (57) (57) (56) (54)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (59) (55) (56) (52)
Liver (60) (60) (60) (60)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 2 (3%)
Hepatocellular Carcinoma 4 (7%) 2 (3%) 6 (10%) 1 (2%)
Hepatocellular Adenoma 10 (17%) 12 (20%) 11 (18%) 4 (7%)
Hepatocellular Adenoma, Multiple 3 (5%) 2 (3%) 4 (7%) 1 (2%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Mesentery (3) (7) (4) (4)
Fibrosarcoma 1 (14%)
Fibrosarcoma, Metastatic 1 (14%)
Pancreas (60) (59) (60) (60)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Salivary Glands (60) (59) (60) (59)
Stomach, Forestomach (60) (58) (59) (59)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Stomach, Glandular (59) (58) (58) (59)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (58)
Adenoma 1 (2%) 1 (2%)
Adenoma, Two 1 (2%)
Capsule, Adenoma 1 (2%)
Adrenal Medulla (58) (55) (56) (56)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (59) (60) (60)
Adenoma 3 (5%)
Carcinoma 1 (2%) 1 (2%)
Pituitary Gland (58) (57) (57) (53)
Pars Distalis, Adenoma 9 (16%) 6 (11%) 5 (9%) 2 (4%)
Pars Distalis, Carcinoma 2 (4%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (60) (60) (59) (59)
Adenoma 1 (2%)
C-Cell, Adenoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1) (2)
Ovary (59) (59) (59) (59)
Cystadenoma 3 (5%)
Granulosa Cell Tumor Benign 1 (2%)
Hemangioma 1 (2%)
Uterus (60) (60) (60) (60)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Polyp Stromal 3 (5%) 1 (2%) 4 (7%)
Sarcoma Stromal 1 (2%)
Page 3
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (60) (59) (58)
Lymph Node (6) (5) (8) (2)
Lymph Node, Mandibular (58) (58) (59) (46)
Lymph Node, Mesenteric (58) (55) (59) (45)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Spleen (60) (60) (58) (58)
Hemangiosarcoma 2 (3%) 2 (3%) 1 (2%)
Thymus (51) (52) (56) (44)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (59) (60) (59)
Fibrosarcoma 3 (5%) 1 (2%) 1 (2%) 3 (5%)
Hemangiosarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Fibrosarcoma, Metastatic 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1)
Fibrosarcoma, Metastatic 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Carcinoma, Metastatic, Pituitary Gland 2 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 4 (7%) 2 (3%) 3 (5%) 2 (3%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (3%)
Carcinoma, Metastatic 1 (2%)
Fibrosarcoma, Metastatic 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic 1 (2%) 1 (2%) 2 (3%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Nose (59) (60) (59) (60)
Page 4
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (57) (53) (56) (54)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%) 4 (7%) 1 (2%)
Lymphoma Malignant Mixed 13 (22%) 9 (15%) 9 (15%) 4 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 35 33 40 18
Total Primary Neoplasms 60 52 67 28
Total Animals with Benign Neoplasms 26 21 28 11
Total Benign Neoplasms 34 27 39 13
Total Animals with Malignant Neoplasms 21 20 26 11
Total Malignant Neoplasms 26 25 28 15
Total Animals with Metastatic Neoplasms 3 3 5 1
Total Metastatic Neoplasm 8 6 5 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 59 60
Scheduled Sacrifice 9 10 10 10
Early Deaths
Moribund 5 5 6 10
Dead 1 2 4 8
Survivors
Terminal Sacrifice 44 43 38 32
Moribund 1
Dead 1
Animals Examined Microscopically 60 60 59 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (53) (57) (56) (50)
Intestine Large, Cecum (57) (59) (57) (56)
Intestine Small, Duodenum (57) (58) (55) (55)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (58) (58) (56) (54)
Adenocarcinoma 1 (2%) 1 (2%)
Intestine Small, Ileum (58) (53) (56) (54)
Liver (60) (60) (58) (60)
Carcinoma, Metastatic 1 (2%)
Hemangiosarcoma 2 (3%) 1 (2%) 1 (2%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 5 (8%) 7 (12%) 7 (12%) 3 (5%)
Hepatocellular Adenoma 13 (22%) 15 (25%) 12 (21%) 10 (17%)
Hepatocellular Adenoma, Multiple 12 (20%) 6 (10%) 5 (9%)
Sarcoma 1 (2%)
Sarcoma, Metastatic 1 (2%)
Pancreas (59) (60) (58) (60)
Hepatocellular Carcinoma, Metastatic 1 (2%)
Sarcoma, Metastatic 1 (2%)
Acinus, Adenoma 1 (2%)
Pharynx (1) (1)
Squamous Cell Carcinoma 1 (100%)
Salivary Glands (60) (60) (59) (60)
Stomach, Forestomach (59) (60) (58) (58)
Sarcoma, Metastatic 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (59) (60)
Hemangioma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (60) (57) (58)
Adenoma 1 (2%)
Capsule, Adenoma 3 (5%)
Islets, Pancreatic (59) (60) (56) (60)
Adenoma 3 (5%) 2 (4%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (56) (57) (54) (52)
Pars Distalis, Adenoma 1 (2%) 1 (2%) 2 (4%)
Thyroid Gland (59) (57) (58) (58)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2)
Hemangiosarcoma, Metastatic 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (59) (59) (60)
Sarcoma 1 (2%)
Prostate (59) (57) (57) (59)
Seminal Vesicle (59) (60) (59) (60)
Testes (60) (60) (59) (60)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (60) (57) (58)
Lymph Node (2) (4)
Lymph Node, Mandibular (41) (50) (51) (43)
Lymph Node, Mesenteric (58) (57) (56) (49)
Hepatocellular Carcinoma, Metastatic 1 (2%)
Sarcoma, Metastatic 1 (2%)
Spleen (59) (60) (58) (60)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 2 (3%) 2 (3%)
Thymus (48) (51) (51) (45)
Page 8
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (59) (59)
Fibroma 1 (2%) 1 (2%)
Fibrosarcoma 1 (2%)
Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (59) (60)
Sarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (59) (60)
Alveolar/Bronchiolar Adenoma 14 (23%) 10 (17%) 7 (12%) 6 (10%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Adenoma, Two 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 3 (5%)
Carcinoma, Metastatic 2 (3%)
Hepatocellular Carcinoma, Metastatic 1 (2%) 2 (3%)
Sarcoma, Metastatic 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (6) (2) (2) (2)
Adenoma 5 (83%) 2 (100%) 1 (50%) 2 (100%)
Carcinoma 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (60) (58) (60)
Urinary Bladder (58) (59) (55) (55)
Hemangioma 1 (2%)
Page 9
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(59) *(60)
Lymphoma Malignant 1 (2%)
Lymphoma Malignant Histiocytic 2 (3%)
Lymphoma Malignant Lymphocytic 1 (2%) 2 (3%) 1 (2%)
Lymphoma Malignant Mixed 5 (8%) 2 (3%) 8 (14%) 2 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:45:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 36 34 29
Total Primary Neoplasms 71 51 58 40
Total Animals with Benign Neoplasms 38 31 27 21
Total Benign Neoplasms 52 37 37 25
Total Animals with Malignant Neoplasms 16 13 17 13
Total Malignant Neoplasms 19 14 21 15
Total Animals with Metastatic Neoplasms 3 2 3
Total Metastatic Neoplasm 3 10 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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Web page last updated on November 11, 2004
