Xiuwen Liu : NIDDK

Scientific Programs

Xiuwen Liu

Dr. Xiuwen Liu joined our laboratory in the summer of 1994 to explore the Jak/Stat signaling pathway in the mammary gland. Xiuwen was the first to clone from the mouse the cDNAs and genes encoding Stat5a and Stat5b. He was also the first to delete the Stat5a from the mouse genome and demonstrate its essential role in the development and differentiation of mammary epithelium.

Dr. Liu left our laboratory to join Bristol Myers as a staff scientist. He is currently the Director for research of Biotherapies.

Publications while at LGP

PubMed search

1. Park, S.-H., Liu, X., Hennighausen, L., Davey, H.W. and Waxman, D.J. (1999). Distinctive roles of Stat5a and Stat5b in sexually dimorphism of hepatic P450 gene expression. Impact of Stat5a gene disruption. J. Biol. Chem., 274, 7421-7430.

2. Dong, F., Liu, X., deKoening, J.P., Touw, I.P., Hennighausen, L., Larner, A. and Grimley, P.M. (1998) Stimulation of Stat5 by granulocyte colony-stimulating factor (G-CSF) is modulated by two distinct cytoplasmic regions of the G-CSF receptor. J. Immunology 161, 6503-6509.

3. Lischke, A. Lischke, Moriggl, R., Brändlein, S., Berchtold, S., Kammer, W., Sebald, W., Groner, B., Liu, X., Hennighausen, L. and Friedrich, K. (1998) The Interleukin-4 Receptor Activates STAT5 by a Mechanism That Relies upon Common -Chain. J. Biol. Chem. 273, 31222-31229.

4. Liu, X., Gallego, M.I., Smith, G.H., Robinson, G.W. and Hennighausen, L. (1998) Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b. Cell Growth & Diff. 9, 795-803.

5. Edwards, G.M., Wilford, F.H., Liu, X., Hennighausen, L., Djiane, J. and Streuli, C.H. (1998) Regulation of mammary differentiation by extracellular matrix involves protein tyrosine phosphatases. J. Biol. Chem. 273, 9495-9500.

6. Nakajima, H., Liu, X.-W., Wynshaw-Boris, A., Rosenthal, L., Imada, K., Finbloom, D., Hennighausen, L. and Leonard, W. (1997) Defective IL-2-induced IL-2 receptor a chain gene expression and IL-2 responsiveness in Stat5a-Deficient mice. Immunity 7, 691-701.

7. Feldman, G.M., Rosenthal, L.A., Liu, X., Hayes, M.P., Wynshaw-Boris, A., Leonard, W.J., Hennighausen, L., and Finbloom, D.S. (1997) Stat5a-deficient mice demonstrate a defect in granulocyte-macrophage colony stimulating factor induced proliferation and gene expression. Blood 90, 1768-1776.

8.Kirken, R.A., Malabara, M.G., Xu, J., Erwin, R.E., DaSilva, L., Liu, X. and Hennighausen, L. (1997) Two discrete regions of interleukin-2 (IL2) receptor-independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase. J.Biol. Chem. 272, 15459-15465.

9. Kirken, R.A., Malabara, M.G., Xu, J., Liu, X., Farrar, W.L., Hennighausen, L., Larner, A., Grimley, P.M. and Rui, H. (1997) Prolactin stimulates serine/tyrosine phosphorylation and heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes. J. Biol. Chem. 272, 14098 14103.

10. Li, M., Liu, X., Robinson, G.W., Bar-Peled, U., Wagner, K.-U., Young, W.S., Hennighausen, L. and Furth, P.A. (1997) Mammary derived signals activate programmed cell death in the involuting gland. Proc. Natl. Acad. Sci. U.S.A. 94, 3425-3430.

11. Liu, X., Robinson, G.W., Wagner, K.-U., Garrett, L., Wynshaw-Boris, A. and Hennighausen, L. (1997) Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes and Dev. 11, 179-186.

12. Oakes, S.A., Cabndotti, F., Johnston, J.A., Chen, Y-Q., Ryan, J.J., Taylor, N., Liu, X., Hennighausen, L., Notarangelo, L.D., Paul, W.E., Blaese, R.M. and O'Shea, J.J. (1996) Signaling via IL-2 and IL-4 in Jak-3 deficient severe combined immunodeficiency lymphocytes: Jak3-dependent and independent pathways. Immunity 5, 605-615.

13. Liu, X., Robinson, G.W. and Hennighausen, L. (1996) Activation of Stat5a And Stat5b by Tyrosine Phosphorylation Is Tightly Linked to Mammary Gland Differentiation. Mol. Endocrinology 10, 1496-1506.

14. Wartmann, M., Cell, N., Hofer, P., Groner, B., Liu, X., Hennighausen, L. and Groner, B. (1996) Lactogenic hormone activation of Stat5 and transcription of the b-casein gene in mammary epithelial cells is independent of p42 ERK2 MAP kinase activity. J. Biol. Chem. 271, 31863 31868.

15. Morrigl, R., Gouilleux-Gruart, V., Jahne, R., Berchtold, S., Gartmann, C., Liu, X., Hennighausen, L., Sottropoulos, A., Groner, B. and Gouilleux, F. (1996) Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype. Mol. Cell. Biol. 16, 5691-5700.

16. Gaffen, S.L., Lai, S.Y., Ha, M., Liu, X., Hennighausen, L., Greene, W.C. and Goldsmith, M.A. (1996) Distinct tyrosine residues within the interleukin-2 receptor b chain drive signal transduction specifcity, redundancy and diversity. J. Biol. Chem. 271, 21381-21390.

17. Russell, D.L., Norman, R.L., Dajee, M., Liu, X., Hennighausen, L. and Richards, J.S. (1996) Prolactin induced activation and binding of Stat proteins to the IL-6RE of the a2 macroglobulin promoter: Relation to the expression of the a2M in rat ovary. Biology of Reproduction 55, 1029-1038.

18. Rosen, R., Winestock, K., Liu, X., Hennighausen, L., and Finbloom, D. (1996) Differential activation of Stat5A and Stat5B by granulocyte-macrophage colony stimulating factor (GMCSF) in human peripheral blood monocytes. Blood 88, 1206-1214.

19. Liu, X.-W., Goulliaux, F., Robinson, G.W., Groner, B. and Hennighausen, L. (1995) Identification and characterization of STAT5 and a novel homologue (STAT5b) involved in prolactin mediated signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci.U.S.A. 92, 8831-8835.

20. Hennighausen, L., Robinson, G.W. and Liu, X. (1997) Developing a mammary gland is a Stat affair. J. Mammary Gland Biology and Neoplasia 2, 365-372.

21. Hennighausen, L., Robinson, G.W., Wagner, K.-U., and Liu, X. (1997) Prolactin signaling in the mammary gland. J. Biol. Chem. 272, 7567-7569.

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