Skip to Content

Link to Upcoming Meetings Link to Members Link to Join SIG Link to Special Items Link to Meeting Archives Link to Related Links

      Item * Starting an Interest Group
        Gives an overview of the NIH IG structure and the key players and lays out the initial steps you need to take to get your group off the ground.
      Item A Note on Terminology
        The terminology of functional genomics is multiplying a great speed-- in particular, new words with the “-omics” suffix. This suffix indicates the high-throughput, quantitative analysis of biological samples, which allows the simultaneous measurement of thousands of biological components such as mRNAs, proteins, or metabolites. The information obtained helps define the parts of the regulome.

The term “regulomics” refers to the genome-wide regulatory network, usually of a cell. Regulomics, like its progenitors and siblings (genomics, physionomics, transcriptomics, metabolomics, etc.) is a type of systems biology, in which biological processes are modeled in a nonlinear, integrative fashion. In the specific case of regulomics, this involves identifying and understanding multiple time- and condition-dependent gene-protein regulatory networks and metabolic pathways underlying cellular processes. The term “physionomics” refers to the quantitative and integrated description of the functional behavior or the physiological state of an individual or species. The physiome describes the physiological dynamics of a normal intact organism and is derived from both information and structure (genome, proteome, and morphome). In its broadest sense, the physiome defines relationships from genome to organism and from functional behavior to gene regulation. It includes integrated models of components of organisms, such as particular organs or cell systems, biochemical pathways, or endocrine systems.
      Item Acute Respiratory Distress Syndrome (ARDS) Network, National Heart, Lung, and Blood Institute (NHLBI)
        The ARDS Network was established as a contract program in 1994 following a national competition. Its goal is to carry out multi-center trials to efficiently test promising agents, devices, or management strategies to improve the care of patients with ARDS. Approximately 35 sites are currently in the ARDS clinical network.
      Item Australia/New Zealand Intensive Care Society (ANZICS)
        ANZICS is the professional and advocacy body for medical practitioners in Australia and New Zealand specializing in the care of critically ill patients. ANZICS research is conducted through its Clinical Trials Group and populated databases, including the Adult Patient Database, the Pediatric Intensive Care Registry, and the ANZICS Research Centre for Critical Care Resources.
      Item Conference Rooms
        Information about obtaining conference rooms and conference room services, as well as about how to have OD cover the cost of the rooms for DDIR-approved groups.
      Item Das Nationale Genomforschungsnetz
        NGFN is a national research project that aims to foster “intense cooperation” among various specialties to clarify the role of genetics in the development of specific diseases that have a high incidence in Germany, prolong suffering, or result in premature death of the people affected. In addition to cancer, cardiovascular disease, and neurological disorders, NGFN is investigating causes and sequelae of infection and inflammation, including trauma and sepsis.
      Item Hosting a Fogarty Scholar (Outside Speaker Support)
      Item Inflammation and the Host Response to Injury
        “Inflammation and the Host Response to Injury” is a large-scale, collaborative research program supported by the National Institute of General Medical Sciences (NIGMS). It aims to uncover the biological reasons for patients having very different outcomes after traumatic injury. This program is the first large-scale interdisciplinary program to attempt to solve the life-threatening problem of inflammation following major trauma or burn injury. Researchers from major institutions cover a wide range of specialties: surgery, genomics, proteomics, biostatistics, bioinformatics, computational biology, genetics, and molecular biology.
      Item National Institute of Neurological Disorders and Stroke (NINDS) Clinical Research Collaboration
        A corollary goal of seeking collaborative approaches to clinical science is the opportunity to recruit community-based practitioners into the research process. This can increase the breadth of patient representation as well as encourage faster adoption of scientifically valid practices. Challenges to this goal can be formidable, as we face inherent differences in health care systems that affect patient recruitment and physician participation, but programs are emerging to facilitate this process. One such program is the National Institute of Neurological Disorders and Stroke (NINDS) Clinical Research Collaboration, which is designed to help patients, family members, and others quickly find actively recruiting research studies. This program gives physicians the opportunity to perform research in their own offices and helps to keep them current on emerging research results.

Critical care research networks are developing all the time, formally and informally. If you would like to add anything you know about collaborative research projects or programs in critical illness and injury, please contact
      Item Publicizing your SIG
        Information about resources such as LISTSERV lists, the CIT-supplied web pages, the Calendar of Events and the NIH Catalyst.
      Item Resource for Nonhuman Primate Immune Reagents
        This NIH/NCRR funded Resource for Nonhuman Primate Immune Reagents provides recombinant protein or recombinant DNA constructs to requestors for a nominal fee.
      Item Special Events and Lectures (WALS, etc)
        Information about the Interest Groups role in nominating and hosting the Wednesday Afternoon Lecture Series (WALS) and other special lectures.
      Item The Canadian Critical Care Trials Group (CCCTG)
        The CCCTG was created in 1989 to improve the care of critically ill patients through investigator-initiated research and to provide a national forum for continuing education about research methods. Today, the 120-member organization has over 30 active research programs. The group’s success has been built on the premise that common interest and collegial collaboration advances progress. CCCTG membership is self-referred and self-funded; to promote research rigor, all protocols are subjected to a pre-submission critique. Selected study subjects include mechanical ventilation therapy, coagulopathy and anemia transfusion triggers, and end-of-life care. CCCTG focuses on therapies with substantial practice variability across communities. The group’s choice to run several pilot studies has helped discern trial feasibility and acceptability as well as to identify protocol violations. See also the Critical Care Research Network at
      Item The Combat Casualty Care Research Program, U.S. Army Medical Research and Material Command
        The mission of this program is to reduce the mortality and morbidity resulting from injuries on the battlefield through the development of new life-saving strategies, new surgical techniques, biological and mechanical products, and the timely use of telemedicine technologies.

Because uncontrolled hemorrhage causes the vast majority of deaths on a conventional battlefield, finding effective ways to stop bleeding “in the field” is a top military research priority. Since genomic approaches suggest significant individual genetic variation in bleeding time, ongoing studies are pursuing additional strategies for tailoring therapy. Neuroprotection from blast injury is another important focus, prompting studies to identify brain injury biomarkers that may offer opportunities for earlier intervention.
      Item The National Collaborative Pediatric Critical Care Research Network
        The National Institute of Child Health and Human Development (NICHHD) has established a collaborative pediatric critical care clinical research network made up of six clinical trial centers (responsible for carrying out research projects) and a data coordinating center (the central biostatistical resource). The network aims to establish an infrastructure to pursue well-designed collaborative clinical trials and meaningful descriptive studies in pediatric critical care medicine. Areas of interest span a wide range of topics including novel therapies, ventilator therapy, trauma and neuroplasticity, high-risk behavior, child abuse and neglect, culturally sensitive care, and fetal antecedents of disease susceptibility. The group welcomes transdisciplinary inquiries.

      Item 2003 SysBio SIG Training Retreat Registration

First. Annual Retreat and Training Program of the NIH Systems Biology SIG

November 8-9, 2003, Airlie House, Warrenton, VA

Click Here for the agenda.
Click Here for the status report to Dr. Zerhouni.

Next Steps in Defining and Supporting “Systems Biology”

Systems approaches to biology are of renewed and growing importance in all aspects of biomedical research. Few will dispute the basic scientific and practical benefits that will come from approaching biology from a systems perspective, but the distinguishing conceptual and methodological approaches of systems biology as an experimental paradigm have not been clearly articulated. Furthermore, it is becoming apparent that systematic approaches to biological discovery will require new technologies, cooperation among investigators with very diverse skills, changes in the breadth and scale of biological investigation, and adjustments in the review and evaluation procedures for granting promotion or awarding funds. These considerations have important implications for extramural scientists as well as intramural investigators, and for those charged with supporting the many research communities now pursuing a systems approach to biology.

Aims. The NIH Systems Biology SIG is holding its first annual retreat with these issues in mind. The conveners of this retreat believe that several points require immediate attention, among them the need to:
(1) acquaint both intramural and extramural staff with the ongoing systems biology activities of the NIH and
(2) address the future skills, knowledge, and infrastructure requirements of systems biologists within NIH and in the extramural community.

To begin to address these needs, the 2003 NIH Systems Biology SIG Annual Retreat and Training Program will seek to characterize the field of systems biology with respect to its theoretical foundations, as well as its defining models and methods. In addition, an attempt will be made to translate this body of knowledge into specific information resources and scientific events that the NIH’s extramural program staff and intramural science communities can use to advance systems biology investigation within and outside of NIH.

Expected Results: By the conclusion of the 2003 NIH Systems Biology SIG Annual Retreat and Training Program it is anticipated that:
  • A Systems Biology Training Program Plan relevant to the extramural and intramural members in NIH Systems Biology SIG will be defined and will include such items as a lecture series, training curricula, and referrals to other educational resources.
  • Plans for a Systems Biology Knowledge Base will be crafted to support the SIG journal club and serve the general information needs of the NIH community with respect to systems biology.
  • An Agenda for the 2004 NIH Systems Biology SIG Retreat, tentatively scheduled for November 2004, will be drafted.
      Item 5th Annual Forum for Improving Children's Health Care
        Scientific Session: Call for Abstracts! Abstracts Due: November 1, 2005 NICHQ will be holding the first annual Scientific Session at its 5th Annual Forum for Improving Children's Health Care March 16-18, 2006 in Orlando Florida. This session will focus on the science of improving children's health care and health care training for improvement. The session will include both platform and poster presentations. The goal of the NICHQ Scientific Session is to identify better ways to improve children's health care and to train child health professionals in improvement. This session seeks to provide a stimulating, cutting edge forum for the presentation and discussion of new research. Studies of efforts to improve health services delivery, methods to assess quality improvement and how to train health professions in improvement will be highlighted in brief presentations. Papers will be selected through peer-review. For each, a ten-minute presentation will be followed by ten minutes of discussion, moderated by health care leaders and researchers. Additional highly rated abstracts will be invited for poster presentations. The 1st Annual Scientific Session will be held on Friday, March 17th, as part of the NICHQ Forum. Abstract Submission Guidelines We are looking for abstracts on innovative approaches to improvement; assessments of improvement interventions, and new methods for studying quality improvement (particularly concerning care of children). This includes interventions and strategies that have been tested using scientific methods such as group randomized trials, quasi-experimental designs, and statistical process control. Topic areas could include information technology, clinical innovations, population specific issues, reducing health disparities, behavioral health, role of families, and sustaining and spreading change. Ten abstracts will be selected for oral presentation only. Additional highly rated abstracts will be selected for poster-only presentation. Selected applicants for the poster-only presentation will be required to attend and present their abstract during the March 17th Forum Storyboard Reception. Please submit abstracts in a single Microsoft Word document of no more than 500 words (excluding contact information and graphs). The single Word file must include all charts and graphs, and follow this abstract structure: 1) Background 2) Purpose of the Study 3) Methods 4) Results 5) Conclusions and Implications Presenters whose papers are selected for poster presentation are responsible for producing posters selected for display in the poster session. Other Information to Include On the abstract, include all of the authors' names and the name and city of the institution in which the work was conducted if applicable. Underline the name of the author who will present the abstract. Also include the key contact person, and their email, phone and fax numbers. Please also share if this work has been published and if so, where? Email your Word document as an attachment to: (The receipt of all abstracts will be acknowledged within 5 days. Please advise if the acknowledgement is not received.) Abstract Selection Process Abstracts will be chosen through peer review by a national panel on the basis of originality and scientific excellence. Studies should be completed, with data summarized in the abstract. Authors are encouraged to present data and include sample measures and analysis. Graphical displays will not be counted in the 500-word limit. Presenter Fees and Responsibilities Authors will be informed of abstract selection decisions by January 1, 2006. The submission of an abstract will be considered as an agreement to present if the abstract is selected. Presenting authors must register for the Scientific Session, but will not have to pay the Scientific Session fee (this does not include co-authors). They will be responsible for their travel expenses. Registration fees for the Scientific Session do not include registration fees for the pre-conference Exploratoriums or NICHQ Forum general conference [but Scientific Session presenters will receive a discount to the general conference - $495] Authors may be asked to edit their abstracts prior to inclusion in the Forum Conference Guide. Abstracts selected for presentation and the email address of the primary author will be posted on our website,, unless the authors request otherwise. For More Information For further information regarding abstract selection and presentation, please contact Bonnie Rains at or (206) 616-6978
      Item A Tribute To Masaru Yamaizumi M.D., Ph.D. 1945-2006
        Masaru Yamaizumi passed away on May 9, 2006. He graduated from Kyoto University Medical School in 1970, and as a graduate student of Osaka University, he joined Prof. Yoshio Okada's laboratory. Prof Okada is a discoverer of Sendai Virus-mediated Cell Fusion. I also joined Okada's group in 1973 as a graduate student. Although Masaru and I studied together for 4 years in Okada's laboratory, we have never overlapped each other with respect to the working time in the lab. When I entered the lab in the morning, I frequently saw Masaru sleeping in his "Schlaf" (Sack). He used to start his experiments after supper and work overnight. He woke up at noon, and in the afternoon he used to play tennis with other students in the Institute. He began playing tennis in Osaka and quickly improved his skill hence and became a top player among the students. However, I should say that he was also a top runner among the students in the research. Once he became interested in something, he always strongly devoted himself to it. He was so skillful in the experiments and nobody could mimic his delicate techniques. During his stay in Okada's laboratory, he developed several sophisticated methods such as red blood cell-ghost fusion to introduce the macromolecules into living mammalian cells. One of his representative works using these methods was the finding that the cell was killed by one molecule of diphtheria toxin fragment A.

After his postdoctoral fellowship in Dr. Frank Ruddle's laboratory in Yale, he became interested in micro-needle injection. He adopted this technique to purify the factor that is missing in XP-A cells. In 1987, he was promoted as Professor in Kumamoto University Medical School, where he finally succeeded in purifying a XPA factor. In Kumamoto, he identified a UV-sensitive syndrome, and discovered human homolog of RAD18 that turned out to be a major player of translesion DNA synthesis. He was a quiet person, yet he has had lots of dreams during his lifetime.

He was only 60 years old when he died. His memorial symposium was held in Kumamoto University on July 21, 2006 and hundred of people including Prof. Okada gathered in this Symposium. We wished for his research to develop and continue even after he is no longer with us.

- Kiyoji Tanaka M.D., Ph.D.
Human Cell Biology Group
Laboratories for Organismal Biosystems
Graduate School of Frontier Biosciences
Osaka University

Posted 7-2006
      Item AAAS Mass Media Science and Engineering Program
        Check the site for application deadlines.
      Item AMWA Annual Conference, October 24-27, 2001
        Norfolk, VA
      Item Archives of the IIG Seminar Series
        As of 9/5/2001 we will be videocasting the IIG Seminar Series. Seminars given on or after this date will be accesible through the archive.
      Item ASP 2008 - June 18 -21, 2008 - West Palm Beach Florida
        Annual meeting of the American Society of Primatologists. Abstracts due: February 1, 2008
        Subject: Flight for medical reasons.

Reminder to all,

There are several sources of help for travel for medical reasons. These are available to help because of the generosity of many others. Let me urge you to note these and file it somewhere.

NPATH 1-800-296-1217 or

Continental Care Force, Bob Jack, Volunteer Administrator, 281-261-6626

AirLifeLine 1-800-444-1231

Miles for Kids American Airlines 817-963-8118.

Corporate Angel 914-328-1313 For Cancer Patients

Mercy Medical Airlift 1-800-296-1191.

Southwest Airlines 214-792-4103

Delta Air Lines Skywish Program 1-800-892-2757

Please file for future time of need.
      Item Behavioral and Social Sciences Research Seminar Series
        Lectures in the behavioral and social sciences on selected topics by leading researchers. Organized by the NIH Behavioral and Social Sciences Research Coordinating Committee. Visit the Web Page to view currently scheduled lectures, abstracts of past lectures, and to receive announcements of forthcoming lectures via e-mail.
      Item Bioethics Resources on the Web
        A comprehensive list of web links has just been created by the Bioethics Interest Group and the Office of Extramural Research.
      Item Biomedicine in the Twentieth Century: Practices, Policies, and Politics
        The Office of NIH History is sponsoring a major two-day conference to be held in the Lister Hill Auditorium (Building 38A) on the NIH campus in Bethesda, Maryland, on December 5-6, 2005. The conference is to honor Dr. Victoria A. Harden, Director, Office of NIH History, on her retirement. Presentations will begin each day at 8:30 am and will continue throughout the day.
      Item Bioprotocol

The BioProtocol website is a repository of protocols, and contains dynamic protocols used in contributing labs. This provides choice of protocols for a single procedure. They are uniformly and logically formatted, designed to be printed and used right at the bench.

      Item Breast Cancer Information Core (BIC)
      Item Breast Cancer Think Tank Funding Available
      Item Building 50
        For a map of the NIH campus, visit the following website
      Item Call for Abstracts

Tenth Annual Norman P. Salzman Memorial Award in Virology
Application Deadline: Tuesday, September 23, 2008

The Foundation for the National Institutes of Health and the NIH Virology Interest Group announce the Tenth Annual Norman P. Salzman Memorial Award in Virology. This award has been established to recognize outstanding research accomplishment by a post-doctoral fellow or research trainee working in the field of virology at the NIH. The award honors the 40-year career of Dr. Salzman in virology research and his accomplishments in mentoring of young scientists. The winning fellow will receive a plaque and an unrestricted gift of $2,500; the mentor of the awardee will also receive a plaque.

Eligible candidates are postdoctoral fellows or other research trainees in intramural NIH, CBER, or SAIC laboratories. Candidates must have obtained their professional degree after November 13, 2002. The research submitted must have been done under the mentorship of an NIH, CBER, or SAIC scientist. Award selection will be based upon the quality and significance of the applicant's research contribution to the field of basic virology, with special emphasis upon the creativity and the rigor with which the research has been performed. Applications will be judged by a selection committee of distinguished scientists from NIH and other institutions. The work submitted must have been published or accepted for publication in a peer reviewed journal. Applicants who have applied in previous years are encouraged to update their applications and resubmit, if eligible.

The award will be presented at the Tenth Annual Norman P. Salzman Virology Symposium, being held on Thursday, November 13, 2008 in the Natcher Conference Center (Building 45) on the NIH campus in Bethesda, MD. The recipient will be expected to give a 20-minute presentation based on the award-winning abstract. The symposium will also feature other prominent speakers in the field of virology. A luncheon reception will follow.

Please pay close attention to the following instructions for submission; applications that fail to follow these directions will not be considered. Fellows should apply by submitting the following materials directly in the body of an e-mail addressed to David Derse, NCI at Applications should contain the following information:

(1) Applicant's name, laboratory, institute or affiliation, address, phone number, and e-mail address

(2) The mentor's name, institute, address, phone number, and e-mail address. Note, mentors may be contacted for further information regarding in press manuscripts.

(3) The title and abstract (maximum length: 400 words) that describes the research that has been published (or accepted for publication/in press). For work that is in press, please also provide official confirmation from the journal of accepted status.

(4) A list of the applicant's relevant publications (maximum: 5)

(5) A list of meeting presentations (maximum: 5) indicating oral or poster

Please note that special characters will not transmit by e-mail and should be spelled out. The deadline for receipt of applications is 5:00 pm September 23, 2007. Applicants will be notified whether their application has been selected by the scientific committee by October 10, 2008.

For further information, please contact either David Derse, NCI ( or Barbara Rehermann, NIDDK (

      Item Carrying Out Genetic Linkage Studies at NIH
        Take advantage of the theoretical and practical expertise available on the NIH campus for learning and applying the latest in genetic linkage analysis.
      Item Cell Cycle Interest Group Symposium
        Co-organizers: Munira A. Basrai and Mirit I. Aladjem Morning session: 10:00 - 12:30 pm Kyung Lee, NCI Licensing mitotic entry: Concerted phosphorylation and down-regulation of Swe1/Wee1 by multiple kinases in budding yeast Karen Ross, NIDDK A role for separase and the FEAR pathway in nuclear positioning Elsa Bronze da Rocha, NCI (University of O’Porto, Portugal) Metaphase Chromosome Protein I (MCP1), a human protein associated with DNA replication James Kastenmayer, NCI Molecular dissection of the S. cerevisiae multifunctional protein Mad1p Yoshiaki Azuma, NICHD SUMO modification in Xenopus egg extracts: regulation and target Ed Davis, NIDDK Regulation of the Anaphase Promoting Complex during meiosis in C. elegans Afternoon session: 10:00 - 12:30 pm Mel Depamphilis, NICHD The "ORC Cycle" in mammalian cells: regulating the onset of DNA replication Mirit Aladjem, NCI Replication Timers: Genetic and epigenetic factors determine when DNA replicates in mammalian cells Myung Kim. NHLBI Effects of ATR, PML and Chk2 on the chemosensitivity of arsenic trioxide Eiman Aleem, NCI The interplay of Cdk2 and p27Kip1 in the mouse" Christophe Redon, NCI H2A and Topoisomerase- induced DNA damage in yeast: genetic analysis and new insights Mary Lilly. NICHD Oscillations of the CDK inhibitor Dacapo help introduce a gap phase during the Drosophila endocycle
      Item CHTN Process
      Item CIG Best Paper Award
        The Cytokine Interest Group sponsors an annual award for NIH postdoctoral fellows. The award will be presented at our 2009 Spring Minisymposium and is awarded to the best postdoctoral fellow publication* (published or accepted for publication in a peer reviewed journal) in cytokine research during the period Jan 1 through Dec.31, 2008. The work must have been initiated and completed while at the NIH/FDA. Postdocs should submit their paper by e-mail to Daniela Verthelyi. Please put CIG award on the subject line. The deadline for submitting papers is January 30, 2009. The winner will be selected by the CIG steering committee. All postdoctoral fellows in the NIH intramural program and fellows in FDA labs on the NIH campus are eligible for consideration.
* Fellow must be first author
      Item CME
        Accreditation Statement.

The National Institutes of Health/Foundation for the Advanced Education in the Sciences (NIH/FAES) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation Statement.

The NIH/FAES designates this educational activity for a maximum of 1 hr category I credits toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity.

CME is also available for licensed nurse practitioners and physicians assistants. A maximum of 18 hrs of credit is available for this activity over a 12 month period.

CME credits will be available for physicians who attend the seminar. CME is also available for those who watch the videocast live and return the evaluation form within 24 hr; please contact Jeffrey Kopp ( to obtain the evaluation form.

      Item Course: The Science of Sex and Gender In Human Health
        Office of Research on Women’s Health, Office of the Director, National Institutes of Health and the Office of Women’s Health, Food and Drug Administration The Science of Sex and Gender In Human Health Course Goals “Sound medical treatment and research must account for sex and gender differences” according to the Institute of Medicine (IOM) Report: Exploring the Biological Contributions to Human Health: Does Sex Matter?. Washington DC: National Academy Press, 2001. Although the NIH and FDA required applicants to their various programs to adhere to these principles prior to the issuing of the IOM report, to date, however, there has never been a standard, uniform method of instruction in how to meet these important demands. Sex and gender differences and similarities have been handled in an ad hoc manner.. This course was designed to create the permanent foundation for sex and gender accountability in medical research and treatment. The course will enable potential researchers, clinicians, and students in the health professions to integrate knowledge of sex and gender differences and similarities with the applicable regulatory requirements. Course Objectives Participants who complete this course will understand: • the scientific basis of known sex and gender differences • the influence of these sex and gender differences on health outcomes and illness • the implications of sex and gender differences for policy, research, and health care • the Federal research regulations. “Understanding the potential contribution of sex and gender factors in health and disease and in morbidity and mortality is critical to the public health and important for the design of research studies and their clinical implications.,” said Vivian Pinn, M.D., Director of NIH ORWH. “This online course will be an excellent resource for investigators and clinicians, ensuring a better understanding of sex and gender differences,” said Kathleen Uhl, M.D., Assistant Commissioner for Women's Health, Director, Office of Women's Health, FDA. Course Format and Content This course, which is free to the public, is self-paced and comprised of six lessons that. cover the definitions of sex and gender; the development and implementation of the Federal research regulations; cell physiology; developmental biology; pharmacodynamics and pharmacokinetics; and clinical applications of genomics. Each lesson is followed by a quiz that allows the participant to assess his/her progress. A second module , which will apply the basic concepts presented in this course to specific conditions and organ systems where sex differences play a significant role, is being developed. Target Audience Although the course was designed with researchers, clinicians, members of academia, and students in health professional schools in mind, all interested citizens should feel free to enroll. Participants who complete all six lesson quizzes with a score of at least 70 percent and complete a brief course evaluation form will receive credit. Participants who do not hold the M.D. degree will receive a certificate from the NIH. The National Institutes of Health/Foundation for Advanced Education in the Sciences (NIH/FAES) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The NIH/FAES designates this educational activity for a maximum of 6 AMA PRA Category 1 Credits.™ Physicians should only claim credit commensurate with the extent of their participation in the activity. Date of original release: June 1, 2006 Date credit expires: May 31, 2009 Anticipated completion time: 6 hours LOGOS: HHS NIH ORWH FDA
      Item CRISP
        CRISP is a searchable database of federally funded biomedical research projects conducted at universities, hospitals, and other research institutions. The database, maintained by the Office of Extramural Research at NIH inlcudes projects funded by the NIH, SAMHSA, HRSA, FDA, CDCP, AHRQ, and OASH. Users, including the public, can use the CRISP interface to search for scientific concepts, emerging trends and techniques, or identify specific projects and/or investigators. For most effective search enter search terms "end-of-life" OR "palliative care".
      Item Cultural and Qualitative Research Interest Group
        This Interest Group is organized to promote awareness of the impact of culture, ethnicity, racial categories, and class on public health research. Goals include encouraging the use of theory-based conceptualization of these terms and their inclusion as variables in NIH and NIH-sponsored research. The group recognizes the importance of both qualitative and quantitative research methods in this area. To this end, the group acts to promote greater awareness of appropriate and rigorous qualitative methods in research on health and disease.

For more information, contact:

Suzanne Heurtin-Roberts, Ph.D.
6130 Executive Blvd, Room 4054
Bethesda, MD 20892
Phone: 301-594-6655

      Item Cytokine multiplex BPAs are now open

The NIH Cytokine Interest Group steering committee is pleased to finally be able to announce the establishment of Blanket Purchase Agreements for cytokine multiplex analysis.  These BPAs offer the NIH community a range of platforms and a wide variety of cytokines and chemokines that can be selected for analysis.  The steering committee does not recommend any particular assay method at this time as it was felt that the NIH community needed to have the opportunity to evaluate different platforms.

The companies selected for the BPAs are:

BPA  00049380
Platform: Searchlight

BPA  00063645
Platform: Microspot Elisa (FAST Quant)
User Name: nihbpa  Password: whatman
Note:  You must have an NIH account to utilize these BPAs.  Also, in order to avoid any confusion, the cost for these assays is the responsibility of the individual labs requesting the testing.

For questions please contact Howard Young or call at 301-846-5700.

      Item Deaths - Anthony Dipple, D.Sc., Ph.D. 1940 -1999
        It is with great sadness that we inform the DNA repair community of the sudden passing of our colleague, Dr. Anthony Dipple, on May 26, 1999. Dr. Dipple was born in 1940 in Mansfield, England and received his Ph.D. in biological chemistry from the University of Birmingham in 1964. He then accepted a research fellowship with the late Charles Heidelberger at the McArdle Laboratory, University of Wisconsin.

In 1966, at the Institute for Cancer Research in London he began what would be his life's work: research on polycyclic aromatic hydrocarbon interactions with DNA. There, with Philip Lawley and Peter Brooks he worked toward establishing the importance of metabolic activation in the action of these carcinogens and elucidating the nature of the bonding of these compounds to DNA.

In 1975, Dr. Dipple moved to the newly created cancer research labs in Frederick, MD to further his research into the molecular mechanisms involved in chemical carcinogenesis. Dr. Dipple was a world authority on the basic chemistry of DNA alkylation and aralkylation. His lab was responsible for extensive spectroscopic characterizations of hydrocarbon-DNA adducts. Dr. Dipple and his colleagues have studied the mutagenic properties of the hydrocarbon-DNA adducts both in vitro and in vivo. Recently, his lab was investigating the effect of hydrocarbon-DNA adduct formation on the cell cycle. Major colleagues of Dr. Dipple have included C. Anita Bigger, Robert C. Moshel, William M. Baird, Ronald G. Harvey, Shantu Amin, Karen Vousden and Donald M. Jerina.

Dr. Dipple has authored 164 papers, given 60 invited lectures, contributed to some 40 symposia, served on 20 review committees, and mentored countless post-docs through his lab in Frederick. In 1980, along with Dr. R.C. Garner he established the journal Carcinogenesis and served as an executive editor until his death. He was co-editor of a IARC Monograph on DNA adducts, an editorial board member for both Chemical Research in Toxicology, and Women and Cancer, and served as a reviewer of manuscripts for 11 other journals. In recognition of his life's accomplishments he was awarded a Doctor of Science degree from the University of Birmingham in 1987.

Dr. Dipple will be missed by the scientific community worldwide for his great scientific contributions. All those who worked with him will miss his patience as a teacher, and the goodwill and support he gave to all.

- Karen Canella, Ph.D.

Posted 5/31/99

      Item Deaths - Erling Christen Seeberg (1946-2004)
        We are saddened to inform you that Dr. Erling Seeberg passed away on December 14, 2004. He bravely fought his illness for years and until recently he was very active in work and leisure. Erling was one of the giants in DNA repair. His lab made critical discoveries in base excision repair and other areas of DNA repair. From his early work on UVR ABC protein to his recent work on RNA repair, his group consistently came up with seminal work.

Erling grew up in Norway and spent his career there aside from some time at Yale in the 1970's and in Strasbourg, France in the 1990's. He received his PhD in 1980 and has been a full professor at Oslo University since 1987.

Erling participated in numerous scientific meetings. He was noted for his excellent talks, his engaging discussions and his enlightening suggestions. He had a profound understanding of the topics that he worked on and had excellent insights into the mechanisms involved. Many of us will remember that aspect but also recall his great sense of humor and his ability to give unscheduled speeches. Above all we appreciate his positive influence on his surroundings.

There are many wonderful stories about Erling. He was truly someone who was able to relish many facets of life and who pursued many interests. His numerous friends and colleagues worldwide will truly miss him and cherish their memories of him.

- Vilhelm Bohr


Posted 9-2-2005

      Item Deaths - Dale W. Mosbaugh, Ph.D. September 2, 1953 – February 17, 2004
        Dale W. Mosbaugh, Ph.D., 1953-2004

We are deeply saddened to inform the Research Community of the sudden death of Dr. Dale W. Mosbaugh on February 17, 2004. Dale was born in Cincinnati, Ohio, where he also grew up. He attended the University of Cincinnati, receiving his baccalaureate in 1975. He continued at the University of Cincinnati as a graduate research assistant in the laboratory of Dr. Ralph Meyer and earned his doctorate in 1979. During his studies with Dr. Meyer, Dale began his life long interest in the enzymology of DNA repair, publishing work on DNA polymerase beta and its interaction with DNase V. Also working in the Meyer Lab at that time was a graduate student who became a life long close friend with Dale, Tom Kunkel.

From Cincinnati, Dale moved to UC Berkeley, where he was a NIH postdoctoral fellow in Dr. Stu Linn’s laboratory from 1979-1983. At Berkeley, Dale conducted extensive biochemical studies on AP endonucleases. In 1980, Dale demonstrated that AP endonuclease isolated from HeLa cells could be divided into two classes. Class I AP endonuclease cleaved on the 3’ side of the AP site, producing 3’-deoxyribose- and 5’-phosphomonoester termini; whereas class II AP endonuclease cleaved on the 5’ side of the AP site, producing 3’-hydroxyl nucleotide and 5’-deoxyribose phosphate termini. Only DNA substrates incised by a class II AP-endonuclease could support DNA synthesis. The class I AP endonuclease is now better known as the AP lyase. In 1984, almost twenty years ago, Dale demonstrated complete small gap-filling by HeLa DNA polymerase beta. Dale and Dr. Linn continued their close association until Dale’s death.

Following his postdoctoral studies, Dale accepted a position as Assistant Professor at the University of Texas at Austin, where he taught and conducted research until 1989. At UT-Austin, Dale focused his research on biochemical studies of nuclear and mitochondrial uracil-DNA glycosylase, cloning of the PBS2 uracil-DNA glycosylase inhibitor gene (ugi), biochemical studies of the Ugi protein, and biochemical studies of porcine DNA polymerase gamma. These studies were continued at Oregon State University in 1989. There, the Mosbaugh laboratory perfected the Activity Gel technique for characterizing DNA metabolizing enzymes. Dale’s other studies at OSU included the fidelity of uracil-initiated repair in human and bacterial cell extracts, the molecular mechanism of Ugi inhibition of uracil-DNA glycosylase, and the structure of the Ugi protein. In 1995, Dale, John Tainer, and their colleagues reported a novel type of protein structure inferred from studies of the Ung•Ugi complex: protein mimicry of DNA.

Dale believed strongly in the scientific endeavor as a community of scholars, and he gave his time selflessly in support of that community. He served for nearly two decades as a grant proposal and program project reviewer. When the Oregon State University Environmental Health Sciences Center lost its director to illness, Dale served as Interim Director and led the effort to a successful renewal of the Center grant. Those who worked with Dale appreciated his qualities of good humor, patience, respect for others, attention to detail, and energetic dedication to science. Dale’s life and career greatly influenced many lives. He is dearly and sorely missed.

Zhigang Wang, Matt Longley, Samuel Bennett, Russ Sanderson, Jung-Suk Sung, and Cheng-Yao Chen

In memory of Dale W. Mosbaugh, a scholarship fund has been set up for a deserving athlete from one of the three local high schools in the Corvallis area where Dale was highly active.

Donations may be made to:

Citizens Bank
The Dale W. Mosbaugh Scholarship Fund
P.O. Box 30
Corvallis, OR 97339


Posted 3-8-2004

      Item Deaths - DAVID B. BUSCH, Ph.D., M.D. 1953-2002
        DAVID B. BUSCH, Ph.D., M.D.
July 25, 1953 - April 11, 2002

It is with great sadness that we announce the passing of our friend and colleague, Dr. David B. Busch who succumbed to leukemia on April 11 at the age of 48 years.

David was a remarkable, intelligent, and dedicated person. He received an undergraduate degree in biochemistry with distinction in 1974, a masters in biophysics in 1976 and Ph.D. in biophysics in 1980 all at the University of California, Berkeley. His Ph.D. work was performed under the guidance of Nobel prize winner, Dr. Donald Glaser. He then earned an M.D. degree in 1982 in a special 2 year program for Ph.D's at the University of Miami. This was followed by residencies in anatomic and clinical pathology at the University of Wisconsin in Madison which culminated in his becoming a Diplomate of the American Board of Pathology in 1986. The same year he joined the Armed Forces Institute of Pathology in Washington, DC where he spent his professional career as a Radiation Pathologist.

His early DNA repair work was focused at discovering DNA repair mutants in Chinese hamster cells. He performed large scale isolation and characterization of UV sensitive DNA repair mutants of these CHO cells. This work led to the discovery of rodent cells that were homologues of several human diseases: xeroderma pigmentosum (XP) complementation group D (ERCC2), group B (ERCC3), group F (ERCC4), group G (ERCC5), Cockayne syndrome group B (ERCC6) and Fanconi anemia group G (UV40). Each of these cell lines was pivotal in the efforts by several laboratories to clone the corresponding these human genes.

Over the last 25 years David had an extremely successful interaction with Dr. Larry Thompson at Lawrence Livermore National Laboratory. Although Larry was not a formal member of David's Ph.D. thesis committee, Larry provided David with guidance and considered him to be a truly outstanding graduate student. David always seemed to understand everything and was able to set high goals for himself and meet them. David ensured that mutants were still being sent to Livermore by technicians after he had gone to medical school.

When the Glaser laboratory closed because of loss of funding, Larry maintained David's mutant collection in liquid nitrogen for about a decade until David established his own laboratory in Washington, DC. David then systematically analyzed the complete collection and produced a series of publications that involved collaborations with scientists in the Netherlands, in Texas, and other places. This extended accomplishment was a reflection of David's thorough, persistent research style. Larry's lab benefitted immensely from David's mutants. Some of the mutant lines have been in a national repository for many years and will continue to serve numerous investigators indefinitely.

When Dr. Kenneth Kraemer first met David, Dr. James Cleaver had been performing clinical diagnostic tests for XP patients in the US. New Federal regulations made it difficult for Jim to continue this work in a research lab. David, who was a card-carrying pathologist in a distinguished institution that was familiar with Federal regulations, stepped in to perform this valuable service.

David put his heart and soul into this important work. He began by offering testing for XP and then expanded to test for Cockayne syndrome and trichothiodystrophy. He tested samples from several hundred patients over the years. These results have changed many people's lives. The Kraemer laboratory and others around the world are currently performing further analysis on many of these cells and will be studying them for years to come.

The laboratory work was only part of his effort. David soon realized that the people whose cells he tested were searching for assistance as well. He regularly visited Camp Sundown, a camp for XP patients, and a similar group for families with Cockayne Syndrome. He brought his cats and his good humor to cheer up those affected with XP and CS. He will be greatly missed.

Kenneth H. Kraemer, M.D., Bethesda, MD
James E. Cleaver, Ph.D., San Francisco, CA
Larry H. Thompson, Ph.D., Livermore, CA


Cards and letters can be sent to his mother:
Mrs. Barbara Busch, 10 Heather Ave, San Francisco, CA 94118

The family requested that donations in David Busch's memory can be made to:
"The XP Society" The XP society also has a tribute to Dr. Busch on their website.
"The Share and Care Cockayne Syndrome network"
or the "memorial scholarship fund for David Busch" at the San Francisco Hebrew Free Loan Association

Of additional interest:
David Busch maintained a website "Myelodysplasia and me" that chronicled the unfortunately rapid course of his disease beginning from diagnosis as a precancer in November 2000

David was fond of exotic cats as can be seen in his other website: "About Jadzia Cattery and Emony's Exotic Cats" which describe his efforts to breed exotic Norwegian forest cats and Canadian lynxes

David Busch prepared an educational CD "Xeroderma Pigmentosum and Cockayne Syndrome - A Multimedia Overview" which includes video clips of patients and researchers . He also made two educational videotapes: "Cockayne Syndrome (CS) and Xeroderma Pigmentosum (XP)" and "DNA Repair Disorder: X-Ray Sensitivity Disorder/Administrative and Regulatory Issues in Laboratory Diagnosis of DNA Repair Deficient Patients". These may be purchased through "the online catalogue of the Armed Forces Institute of Pathology" . Look in the "Study sets" heading.

Posted 9/05/2002

      Item DEATHS- A TRIBUTE TO LARRY GROSSMAN Ph.D. 1924 – 2006
        Lawrence (Larry) Grossman passed away on January 13, 2006, and with him we lost one of the great pioneers and leaders in the field of DNA repair. Larry was a fighter pilot during WWII and his plane was shot down over the Pacific. He was saved after two days alone on a small raft in the ocean.

After the war he studied biochemistry and became a professor at Brandeis University, and later department chair at Johns Hopkins University at the School of Public Health, now called the Bloomberg School. He developed an outstanding department and recruited many leading scientists in the general area of biochemistry of DNA metabolism. Larry's own research focused on two areas. The first was pioneering work in understanding excision repair in bacterial systems. He clarified the biochemical properties and function of the components of the UVr ABC excinuclease. Later in his career he pioneered population studies on DNA repair. He developed methods to measure DNA repair in blood samples from large numbers of subjects. He then trained and collaborated with epidemiologists to correlate DNA repair capacity with risk of cancers in large populations. It is rare that a scientist masters these diverse areas of biochemistry and epidemiology and is able to make important contributions to both.

Larry trained many students and postdoctoral fellows and there is a great devotion to him amongst them. This is because of Larry's magnetic personality, great care and interest for others and his wonderful sense of humor. He loved to tell stories and wouldn't hesitate to make fun of himself as well. Classic is his joke: "When I gave a lecture at a University, I started by asking the audience if everyone could hear me. From the back row someone raised their hand and said: Yes, I can hear you, Dr. Grossman, but I would be glad to switch places with someone who can’t."

Larry was born in 1924 and lived a full life. He and his lovely wife Barbara (Bobbie) traveled to many meetings all around the world. More recently they spent the summers at their house in Woods Hole, MA, where they had many friends and Larry would participate in scientific seminars and discussions.

Dr. Larry Grossman gave a videoconference talk to the DNA Repair Interest Group on Tuesday, May 25, 1999. The talk was on the history of DNA Repair titled "Four decades of DNA Repair: From populations of molecules to populations of people.". The video is archived on "videocast-DNA Repair Interest Group Sessions" website. A tribute to Larry can also be viewed at "Tribute to Larry Grossman"

Vilhelm A. Bohr, Mohammad Hedayati and Kenneth H. Kraemer



To honor Larry Grossman's life as a scientist and as a special human being, the Department of Biochemistry and Molecular Biology held a memorial for him on February 21, 2006, in the Bloomberg School of Public Health.

If you would like to make a gift in honor of Larry Grossman, his family has requested that any donations be directed to the Lawrence Grossman Lectureship. It is our hope that this endowed lecture fund will support an annual lecture by a prominent researcher working in the area of DNA repair, providing an opportunity to remind future generations of Larry's inspirational personal qualities as well as his enormous contributions to the research field he helped found. Donations by check made out to JHU can be mailed to:

Ms. Yolanda Tillett,
Development and Alumni Affairs Johns Hopkins Bloomberg School of Public Health 615 North Wolfe Street, W1600 Baltimore, MD 21205

For more information contact:

Dr. Les Hanakahi
Johns Hopkins University Bloomberg School of Public Health
Department of Biochemistry and Molecular Biology
615 North Wolfe Street
Baltimore, MD 21205
email:; Tel: (1+) 443-287-2515 (office)

      Item Department of Defense Breast Cancer Research Program Concept Award Program Announcement
      Item DNA Repair Group Meetings
        A listing of all previous DNA Repair meetings from 1995 through 1998.
      Item Evergreen phage meeting
        The Evergreen phage meeting will be July 23-28, 2003. Please contact Dr. Kutter at or visit
      Item FCIG Steering Committee Meeting minutes 10-13-05
      Item First Town Hall Meeting Webcast Available
        The NIH SS/SC Organization First Town Hall Meeting is available at the NIH VideoCasting site:
      Item Focus on Culture
        The theme for the upcoming year 1999/2000 will be Culture and Health. Having spent most of last year focused on issues of qualitative research methods, the Interest Group has decided to give more attention to Culture and Ethnicity this year. This does not imply a lessened interest or commitment to promoting excellence in qualitative health research. Rather it represents a move to a more balanced direction of the group's energies. It should be an interesting and an exciting year!
      Item Immunology Journal Club
        Will cover a broad range of immunological issues. Current emphases include B cell development, viral immunity (HIV, influenza), and molecular biology of immunoglobulin loci. Info: 4:00 PM on Thursdays, Bldg. 29A, Room 1A09. Contact: Suzanne Epstein
      Item Indigent Prescription Pharmaceuticals Program
        Investigate assistance with obtaining prescription pharmaceuticals
      Item Information for Speakers and Presenters
      Item ISDP 2008 - November 2008 - Washington D. C.
        Annual meeting of the International Society for Developmental Psychobiology. Abstracts due: not announced yet
      Item ISSFAL information
        Additional information about the International Society for the Study of Fatty Acids and Lipids (ISSFAL) and some worldwide email discussions of ISSFAL members about fatty acids is presented here.
      Item Journal Announcement / Call for Papers
Palliative & Supportive Care is an international journal of palliative medicine that focuses on the psychiatric, psychosocial, spiritual, existential, ethical, and philosophical aspects of palliative care. The journal’s aim is to serve as an educational resource for practitioners from a wide array of disciplines engaged in the delivery of care to those with life threatening illnesses along the entire continuum of care from diagnosis to the end of life.
      Item KMIG's Frequently Asked Questions


Link to NIH Home       Link to  Home

[IG Home]     [Mtgs/Seminars]     [Members]     [Join the SIG]     [Special Items]     [Archives]     [Related Links]