Announcements       Cell Cycle Interest Group Symposium         Co-organizers: Munira A. Basrai and Mirit I. Aladjem Morning session: 10:00 - 12:30 pm Kyung Lee, NCI Licensing mitotic entry: Concerted phosphorylation and down-regulation of Swe1/Wee1 by multiple kinases in budding yeast Karen Ross, NIDDK A role for separase and the FEAR pathway in nuclear positioning Elsa Bronze da Rocha, NCI (University of O’Porto, Portugal) Metaphase Chromosome Protein I (MCP1), a human protein associated with DNA replication James Kastenmayer, NCI Molecular dissection of the S. cerevisiae multifunctional protein Mad1p Yoshiaki Azuma, NICHD SUMO modification in Xenopus egg extracts: regulation and target Ed Davis, NIDDK Regulation of the Anaphase Promoting Complex during meiosis in C. elegans Afternoon session: 10:00 - 12:30 pm Mel Depamphilis, NICHD The "ORC Cycle" in mammalian cells: regulating the onset of DNA replication Mirit Aladjem, NCI Replication Timers: Genetic and epigenetic factors determine when DNA replicates in mammalian cells Myung Kim. NHLBI Effects of ATR, PML and Chk2 on the chemosensitivity of arsenic trioxide Eiman Aleem, NCI The interplay of Cdk2 and p27Kip1 in the mouse" Christophe Redon, NCI H2A and Topoisomerase- induced DNA damage in yeast: genetic analysis and new insights Mary Lilly. NICHD Oscillations of the CDK inhibitor Dacapo help introduce a gap phase during the Drosophila endocycle             Events       Seminar - Dr. John Tower, University of Southern California         Dr. John Tower from the University of Southern California will present a seminar on "Sequence-specific DNA replication origin and replicator elements in the Drosophila chorion gene locus". Time: Thursday, March 8th, 2 p.m. Location: Building 32T, conference room. For more information, or to schedule a meeting with the speaker, please contact Mirit Aladjem at 301-435-2848             The Cell Cycle - symposium in the NIH research festival         Chaired by: Mary Lilly (NICHD) and Orna Cohen-Fix (NIDDK) The regulation of proliferation and growth is fundamental to the life cycle of all organisms. Research over the past two decades has revealed tremendous evolutionary conservation in the molecular mechanisms that govern cell cycle progression. This session will focus on recent progress in understanding the regulation of various cell cycle processes including DNA replication, mitotic progression and cell division. In addition, we will discuss how components of the cell cycle machinery can serve as targets for cancer therapy. For speakers and titles, see seminar list             Job Notices       Postdoctoral position         A new postdoctoral position is available at the Laboratory of Molecular Pharmacology, NCI, to study the initiation of DNA replciation (PI: Dr. Mirit Aladjem). This is a 3 year position funded by a competitive intramural research award. To apply, please email Dr. Aladjem or visit the web site for more information.