The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a meeting focusing on protein folding and misfolding, especially within the endoplasmic reticulum. There is extensive new research on this topic and on the mechanisms by which disease-associated proteins aggregate and injure cells. Speakers will address both basic science and clinical issues, and several will discuss new concepts for therapeutics, including the use of small molecules and chaperones to prevent protein misfolding or aggregation, to enhance the removal of toxic protein aggregates, or to block the cellular response to the defective protein. Plenary talks, selected short talks, and a poster session will provide a forum for interactions among both basic and clinical scientists, as well as established and new investigators in the field.     ORGANIZING COMMITTEE Carol Haft, Ph.D. NIDDK Jeff Kelly, Ph.D. The Scripps Research Institute Chris Ketchum, Ph.D. NIDDK Show-Ling Shyng, Ph.D. Oregon Health Sciences University David Perlmutter, M.D. University of Pittsburgh David Ron, M.D. New York University Medical Center Alan Verkman, M.D. , Ph.D. University of California, San Francisco