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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 Facility: Battelle Columbus Laboratory Chemical CAS #: 120-32-1 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 7| 6| 4| 6| 7| 7| 0| 5| 4| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 5| 4| 7| DAY ON TEST | 8| 2| 8| 5| 7| 2| 2| 2| 6| 5| 2| 2| 2| 2| 2| 6| 1| 5| 2| 7| 5| 3| 2| 5| 3| | 3| 9| 0| 6| 6| 6| 9| 3| 8| 7| 9| 9| 9| 9| 9| 5| 6| 6| 9| 0| 6| 0| 1| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Craniopharyngioma | X | Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X | Pars Distalis, Adenoma, Multiple | | Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 7| 6| 4| 6| 7| 7| 0| 5| 4| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 5| 4| 7| DAY ON TEST | 8| 2| 8| 5| 7| 2| 2| 2| 6| 5| 2| 2| 2| 2| 2| 6| 1| 5| 2| 7| 5| 3| 2| 5| 3| | 3| 9| 0| 6| 6| 6| 9| 3| 8| 7| 9| 9| 9| 9| 9| 5| 6| 6| 9| 0| 6| 0| 1| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | Carcinoma | X X X | Bilateral, Adenoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X | Polyp Stromal, Multiple | X | Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Fibroadenoma | X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 7| 6| 4| 6| 7| 7| 0| 5| 4| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 5| 4| 7| DAY ON TEST | 8| 2| 8| 5| 7| 2| 2| 2| 6| 5| 2| 2| 2| 2| 2| 6| 1| 5| 2| 7| 5| 3| 2| 5| 3| | 3| 9| 0| 6| 6| 6| 9| 3| 8| 7| 9| 9| 9| 9| 9| 5| 6| 6| 9| 0| 6| 0| 1| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Gland | X | Leukemia Mononuclear | X | Oligodendroglioma Benign | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Papilloma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 3| 6| 4| 7| 6| 7| 7| 7| 7| 6| 4| 7| 6| 6| 7| DAY ON TEST | 1| 3| 3| 3| 8| 5| 3| 3| 0| 3| 1| 8| 5| 3| 5| 3| 3| 3| 3| 8| 5| 3| 0| 2| 3| | 7| 0| 0| 0| 0| 6| 0| 0| 1| 5| 7| 0| 7| 0| 9| 1| 1| 0| 1| 2| 7| 1| 3| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Mesentery | + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + M + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Craniopharyngioma | | Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X| Pars Distalis, Adenoma, Multiple | X X | Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X X X X| C-Cell, Carcinoma | | Follicular Cell, Adenoma | X X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 3| 6| 4| 7| 6| 7| 7| 7| 7| 6| 4| 7| 6| 6| 7| DAY ON TEST | 1| 3| 3| 3| 8| 5| 3| 3| 0| 3| 1| 8| 5| 3| 5| 3| 3| 3| 3| 8| 5| 3| 0| 2| 3| | 7| 0| 0| 0| 0| 6| 0| 0| 1| 5| 7| 0| 7| 0| 9| 1| 1| 0| 1| 2| 7| 1| 3| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | Bilateral, Adenoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Stromal | X X X | Polyp Stromal, Multiple | | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Thymoma Benign | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Fibroadenoma | X X X X X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 3| 6| 4| 7| 6| 7| 7| 7| 7| 6| 4| 7| 6| 6| 7| DAY ON TEST | 1| 3| 3| 3| 8| 5| 3| 3| 0| 3| 1| 8| 5| 3| 5| 3| 3| 3| 3| 8| 5| 3| 0| 2| 3| | 7| 0| 0| 0| 0| 6| 0| 0| 1| 5| 7| 0| 7| 0| 9| 1| 1| 0| 1| 2| 7| 1| 3| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Gland | X | Leukemia Mononuclear | | Oligodendroglioma Benign | X | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Papilloma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 5| 5| 7| 7| 7| 5| 4| | | DAY ON TEST | 5| 1| 3| 0| 9| 3| 3| 3| 7| 5| | | | 7| 7| 1| 0| 8| 1| 1| 1| 7| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 0MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | X X X | 14 | __________________________________________________________________________|____________| Mesentery | | 4 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 56 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Craniopharyngioma | | 1 | Leukemia Mononuclear | | 3 | Pars Distalis, Adenoma | X | 17 | Pars Distalis, Adenoma, Multiple | X | 3 | Pars Distalis, Carcinoma | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | C-Cell, Adenoma | X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 5| 5| 7| 7| 7| 5| 4| | | DAY ON TEST | 5| 1| 3| 0| 9| 3| 3| 3| 7| 5| | | | 7| 7| 1| 0| 8| 1| 1| 1| 7| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 0MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 59 | Adenoma | X | 7 | Carcinoma | X | 5 | Bilateral, Adenoma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 2 | Polyp Stromal | | 4 | Polyp Stromal, Multiple | | 1 | Sarcoma Stromal | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | Mediastinal, Leukemia Mononuclear | X X | 7 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 59 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 14 | __________________________________________________________________________|____________| Thymus | + + + + + + M + + + | 58 | Leukemia Mononuclear | X | 4 | Thymoma Benign | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 59 | Adenocarcinoma | | 2 | Fibroadenoma | X | 13 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 5| 5| 7| 7| 7| 5| 4| | | DAY ON TEST | 5| 1| 3| 0| 9| 3| 3| 3| 7| 5| | | | 7| 7| 1| 0| 8| 1| 1| 1| 7| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 0MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Squamous Cell Carcinoma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Pituitary | | | Gland | | 2 | Leukemia Mononuclear | X | 2 | Oligodendroglioma Benign | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 14 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Transitional Epithelium, Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 0MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 13HUCC F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 0MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 13HUCC F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + + + | 9 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 7| 7| 0| 7| 7| 0| 6| 7| 7| 7| 7| 4| 7| 4| 6| 6| 7| 4| 7| 7| 4| 7| 7| 7| DAY ON TEST | 4| 2| 2| 1| 2| 2| 7| 3| 2| 2| 2| 2| 5| 2| 5| 2| 6| 2| 5| 3| 3| 5| 1| 3| 3| | 4| 9| 9| 5| 9| 9| 6| 3| 9| 9| 9| 9| 7| 9| 7| 9| 3| 9| 7| 0| 0| 7| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 60MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Mesentery | | Leukemia Mononuclear | | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Pharynx | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 7| 7| 0| 7| 7| 0| 6| 7| 7| 7| 7| 4| 7| 4| 6| 6| 7| 4| 7| 7| 4| 7| 7| 7| DAY ON TEST | 4| 2| 2| 1| 2| 2| 7| 3| 2| 2| 2| 2| 5| 2| 5| 2| 6| 2| 5| 3| 3| 5| 1| 3| 3| | 4| 9| 9| 5| 9| 9| 6| 3| 9| 9| 9| 9| 7| 9| 7| 9| 3| 9| 7| 0| 0| 7| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 60MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + + + + + + +| Adenoma | X X X X | Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | Polyp Stromal | X | Polyp Stromal, Multiple | | Sarcoma Stromal | X | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + +| Deep Cervical, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Squamous Cell Carcinoma, Metastatic, | | Nose | | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Fibroadenoma | X X X X | Fibroadenoma, Multiple | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + M + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 7| 7| 0| 7| 7| 0| 6| 7| 7| 7| 7| 4| 7| 4| 6| 6| 7| 4| 7| 7| 4| 7| 7| 7| DAY ON TEST | 4| 2| 2| 1| 2| 2| 7| 3| 2| 2| 2| 2| 5| 2| 5| 2| 6| 2| 5| 3| 3| 5| 1| 3| 3| | 4| 9| 9| 5| 9| 9| 6| 3| 9| 9| 9| 9| 7| 9| 7| 9| 3| 9| 7| 0| 0| 7| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 60MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Keratoacanthoma | | Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Squamous Cell | | Carcinoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Lids, Squamous Cell Carcinoma, | | Metastatic, Nose | | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 4| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 6| 4| 7| 4| 6| 7| 7| 7| 6| 7| 7| 6| DAY ON TEST | 4| 3| 5| 3| 3| 3| 7| 5| 5| 2| 3| 3| 3| 9| 5| 3| 5| 4| 3| 3| 3| 7| 3| 3| 3| | 8| 0| 6| 0| 0| 2| 6| 6| 7| 4| 0| 0| 0| 2| 6| 1| 6| 9| 1| 1| 1| 4| 1| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 60MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Pharynx | + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + M + + + M + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 4| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 6| 4| 7| 4| 6| 7| 7| 7| 6| 7| 7| 6| DAY ON TEST | 4| 3| 5| 3| 3| 3| 7| 5| 5| 2| 3| 3| 3| 9| 5| 3| 5| 4| 3| 3| 3| 7| 3| 3| 3| | 8| 0| 6| 0| 0| 2| 6| 6| 7| 4| 0| 0| 0| 2| 6| 1| 6| 9| 1| 1| 1| 4| 1| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 60MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + M + + + + + + +| Adenoma | X X | Carcinoma | X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X | Polyp Stromal | X X X X| Polyp Stromal, Multiple | X | Sarcoma Stromal | | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + +| Deep Cervical, Leukemia Mononuclear | X | Mediastinal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Squamous Cell Carcinoma, Metastatic, | | Nose | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + M + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Fibroadenoma | X X X X X X| Fibroadenoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 4| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 6| 4| 7| 4| 6| 7| 7| 7| 6| 7| 7| 6| DAY ON TEST | 4| 3| 5| 3| 3| 3| 7| 5| 5| 2| 3| 3| 3| 9| 5| 3| 5| 4| 3| 3| 3| 7| 3| 3| 3| | 8| 0| 6| 0| 0| 2| 6| 6| 7| 4| 0| 0| 0| 2| 6| 1| 6| 9| 1| 1| 1| 4| 1| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 60MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Keratoacanthoma | X | Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Squamous Cell | | Carcinoma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | Lids, Squamous Cell Carcinoma, | | Metastatic, Nose | X | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 6| 6| 6| 6| | | DAY ON TEST | 3| 3| 3| 3| 5| 2| 6| 1| 7| 4| | | | 1| 1| 1| 1| 6| 5| 0| 0| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 60MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 54 | Leukemia Mononuclear | X X X X | 13 | __________________________________________________________________________|____________| Mesentery | | 3 | Leukemia Mononuclear | | 1 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 50 | Leukemia Mononuclear | | 1 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Pharynx | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + | 50 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + | 50 | Leukemia Mononuclear | X X | 4 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + | 44 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 6| 6| 6| 6| | | DAY ON TEST | 3| 3| 3| 3| 5| 2| 6| 1| 7| 4| | | | 1| 1| 1| 1| 6| 5| 0| 0| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 60MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + | 51 | Leukemia Mononuclear | X | 4 | Pars Distalis, Adenoma | X X | 14 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + | 50 | Leukemia Mononuclear | | 1 | C-Cell, Adenoma | X X | 6 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + | 48 | Adenoma | X | 7 | Carcinoma | | 2 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 52 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + | 50 | Leiomyoma | | 1 | Polyp Stromal | | 5 | Polyp Stromal, Multiple | | 1 | Sarcoma Stromal | | 1 | __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + | 50 | Deep Cervical, Leukemia Mononuclear | | 1 | Mediastinal, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 4 | Squamous Cell Carcinoma, Metastatic, | | | Nose | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + + + | 48 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 6| 6| 6| 6| | | DAY ON TEST | 3| 3| 3| 3| 5| 2| 6| 1| 7| 4| | | | 1| 1| 1| 1| 6| 5| 0| 0| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 60MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X | 16 | __________________________________________________________________________|____________| Thymus | + + + + M + + + + | 46 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + | 50 | Adenoma | | 2 | Fibroadenoma | | 10 | Fibroadenoma, Multiple | X | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + | 50 | Keratoacanthoma | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X X X | 14 | __________________________________________________________________________|____________| Nose | + + + + + + + + + | 50 | Nasolacrimal Duct, Squamous Cell | | | Carcinoma | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 4 | Lids, Squamous Cell Carcinoma, | | | Metastatic, Nose | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 6| 6| 6| 6| | | DAY ON TEST | 3| 3| 3| 3| 5| 2| 6| 1| 7| 4| | | | 1| 1| 1| 1| 6| 5| 0| 0| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 60MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X | 8 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X | 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 60MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | 13HUCC F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 4| 5| 6| 5| 4| 7| 7| 7| 7| 7| DAY ON TEST | 2| 8| 2| 5| 2| 8| 2| 2| 2| 0| 2| 7| 2| 4| 2| 5| 8| 6| 9| 5| 3| 3| 3| 3| 3| | 9| 0| 9| 6| 9| 2| 9| 9| 9| 8| 9| 9| 9| 9| 9| 6| 3| 6| 8| 7| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 120MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + M M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + +| Pars Distalis, Adenoma | X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 4| 5| 6| 5| 4| 7| 7| 7| 7| 7| DAY ON TEST | 2| 8| 2| 5| 2| 8| 2| 2| 2| 0| 2| 7| 2| 4| 2| 5| 8| 6| 9| 5| 3| 3| 3| 3| 3| | 9| 0| 9| 6| 9| 2| 9| 9| 9| 8| 9| 9| 9| 9| 9| 6| 3| 6| 8| 7| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 120MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | Fibrous Histiocytoma, Metastatic, | | Skin | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thymus | + + M + + + + + + + M + + + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Fibroadenoma | X X X X X| Fibroadenoma, Multiple | X X | Fibrous Histiocytoma, Metastatic, | | Skin | X | __________________________________________________________________________| Skin | + M + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibrous | | Histiocytoma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 4| 5| 6| 5| 4| 7| 7| 7| 7| 7| DAY ON TEST | 2| 8| 2| 5| 2| 8| 2| 2| 2| 0| 2| 7| 2| 4| 2| 5| 8| 6| 9| 5| 3| 3| 3| 3| 3| | 9| 0| 9| 6| 9| 2| 9| 9| 9| 8| 9| 9| 9| 9| 9| 6| 3| 6| 8| 7| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 120MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Benign | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mediastinum, Fibrous Histiocytoma, | | Metastatic, Skin | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | Leukemia Mononuclear | X | Transitional Epithelium, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 0| 6| 6| 6| 6| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 4| 3| 4| 4| 5| DAY ON TEST | 4| 3| 6| 3| 3| 1| 6| 7| 2| 6| 3| 3| 5| 3| 0| 7| 3| 3| 3| 4| 5| 4| 5| 5| 6| | 5| 0| 8| 0| 0| 9| 5| 6| 2| 2| 0| 1| 6| 1| 9| 1| 1| 1| 1| 0| 6| 5| 7| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 120MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | A + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 0| 6| 6| 6| 6| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 4| 3| 4| 4| 5| DAY ON TEST | 4| 3| 6| 3| 3| 1| 6| 7| 2| 6| 3| 3| 5| 3| 0| 7| 3| 3| 3| 4| 5| 4| 5| 5| 6| | 5| 0| 8| 0| 0| 9| 5| 6| 2| 2| 0| 1| 6| 1| 9| 1| 1| 1| 1| 0| 6| 5| 7| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 120MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X X X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Fibrous Histiocytoma, Metastatic, | | Skin | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Fibroadenoma | X X X X| Fibroadenoma, Multiple | | Fibrous Histiocytoma, Metastatic, | | Skin | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 0| 6| 6| 6| 6| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 4| 3| 4| 4| 5| DAY ON TEST | 4| 3| 6| 3| 3| 1| 6| 7| 2| 6| 3| 3| 5| 3| 0| 7| 3| 3| 3| 4| 5| 4| 5| 5| 6| | 5| 0| 8| 0| 0| 9| 5| 6| 2| 2| 0| 1| 6| 1| 9| 1| 1| 1| 1| 0| 6| 5| 7| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 120MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Benign | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Mediastinum, Fibrous Histiocytoma, | | Metastatic, Skin | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + + | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | | Transitional Epithelium, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 4| 7| 6| 4| 4| | | DAY ON TEST | 3| 7| 3| 3| 3| 5| 3| 7| 5| 0| | | | 1| 0| 1| 1| 1| 7| 1| 0| 7| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 120MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 52 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + | 51 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 51 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 51 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + | 51 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 51 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 52 | Leukemia Mononuclear | X X | 10 | __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 50 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + | 52 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 52 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 51 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + | 51 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + | 51 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + | 51 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + | 51 | Leukemia Mononuclear | | 1 | Pheochromocytoma Benign | X | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 50 | Adenoma | X | 1 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M M + | 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 4| 7| 6| 4| 4| | | DAY ON TEST | 3| 7| 3| 3| 3| 5| 3| 7| 5| 0| | | | 1| 0| 1| 1| 1| 7| 1| 0| 7| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 120MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + | 51 | Pars Distalis, Adenoma | X X | 13 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 51 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | C-Cell, Adenoma | X | 6 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + | 50 | Adenoma | X | 4 | Carcinoma | X | 2 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + | 51 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + | 53 | Polyp Stromal | | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 51 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 51 | Mediastinal, Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 51 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 51 | Leukemia Mononuclear | X X | 11 | __________________________________________________________________________|____________| Thymus | + + + + + + + M | 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 50 | Adenocarcinoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 4| 7| 6| 4| 4| | | DAY ON TEST | 3| 7| 3| 3| 3| 5| 3| 7| 5| 0| | | | 1| 0| 1| 1| 1| 7| 1| 0| 7| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 120MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Fibroadenoma | X X X X X X | 15 | Fibroadenoma, Multiple | | 2 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 50 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 51 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 51 | Astrocytoma Benign | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + | 51 | Leukemia Mononuclear | X X | 8 | Mediastinum, Fibrous Histiocytoma, | | | Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 51 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 51 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + | 7 | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | Leukemia Mononuclear | X | 2 | Transitional Epithelium, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 51 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 4| 7| 6| 4| 4| | | DAY ON TEST | 3| 7| 3| 3| 3| 5| 3| 7| 5| 0| | | | 1| 0| 1| 1| 1| 7| 1| 0| 7| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 120MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ Skin | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 7| 7| 9| 9| 9| 9| 9| 9| | | | 4| 4| 9| 9| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | A | 120MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 13HUCC F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 4| 4| 5| 4| 4| 6| 4| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 6| 6| 4| 6| 6| DAY ON TEST | 2| 2| 5| 9| 5| 5| 7| 8| 5| 2| 2| 4| 2| 2| 4| 2| 8| 2| 2| 5| 2| 2| 5| 7| 1| | 9| 9| 7| 3| 4| 7| 1| 4| 6| 9| 9| 8| 9| 9| 1| 9| 0| 9| 9| 2| 2| 4| 6| 6| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 240MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Mesentery | + | Liposarcoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 4| 4| 5| 4| 4| 6| 4| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 6| 6| 4| 6| 6| DAY ON TEST | 2| 2| 5| 9| 5| 5| 7| 8| 5| 2| 2| 4| 2| 2| 4| 2| 8| 2| 2| 5| 2| 2| 5| 7| 1| | 9| 9| 7| 3| 4| 7| 1| 4| 6| 9| 9| 8| 9| 9| 1| 9| 0| 9| 9| 2| 2| 4| 6| 6| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 240MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + M + + + + + + + M + + + + + + + +| Adenoma | X | Carcinoma | X X | Bilateral, Adenoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X | Polyp Stromal, Multiple | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + M + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | X | Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 4| 4| 5| 4| 4| 6| 4| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 6| 6| 4| 6| 6| DAY ON TEST | 2| 2| 5| 9| 5| 5| 7| 8| 5| 2| 2| 4| 2| 2| 4| 2| 8| 2| 2| 5| 2| 2| 5| 7| 1| | 9| 9| 7| 3| 4| 7| 1| 4| 6| 9| 9| 8| 9| 9| 1| 9| 0| 9| 9| 2| 2| 4| 6| 6| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 240MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Renal Tubule, Adenoma | | Transitional Epithelium, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 6| 6| 7| 6| DAY ON TEST | 5| 0| 2| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 9| 3| 8| | 6| 5| 9| 2| 0| 0| 6| 7| 0| 0| 0| 0| 6| 0| 0| 0| 1| 7| 1| 1| 7| 9| 3| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 240MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Mesentery | + + + | Liposarcoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 6| 6| 7| 6| DAY ON TEST | 5| 0| 2| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 9| 3| 8| | 6| 5| 9| 2| 0| 0| 6| 7| 0| 0| 0| 0| 6| 0| 0| 0| 1| 7| 1| 1| 7| 9| 3| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 240MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + + + + + M + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Bilateral, Adenoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X X X X X | Polyp Stromal, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 6| 6| 7| 6| DAY ON TEST | 5| 0| 2| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 9| 3| 8| | 6| 5| 9| 2| 0| 0| 6| 7| 0| 0| 0| 0| 6| 0| 0| 0| 1| 7| 1| 1| 7| 9| 3| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 240MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + +| __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Renal Tubule, Adenoma | X | Transitional Epithelium, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| | | DAY ON TEST | 3| 3| 6| 3| 3| 2| 8| 0| 4| 3| | | | 1| 1| 1| 1| 1| 4| 0| 0| 9| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 240MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X X | 17 | __________________________________________________________________________|____________| Mesentery | + | 5 | Liposarcoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 3 | Pheochromocytoma Benign | X X X | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + | 57 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | Pars Distalis, Adenoma | X X X X | 19 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Bilateral, C-Cell, Adenoma | | 1 | C-Cell, Adenoma | X X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| | | DAY ON TEST | 3| 3| 6| 3| 3| 2| 8| 0| 4| 3| | | | 1| 1| 1| 1| 1| 4| 0| 0| 9| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 240MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 56 | Adenoma | X | 3 | Carcinoma | | 2 | Bilateral, Adenoma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Polyp Stromal | X | 11 | Polyp Stromal, Multiple | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 59 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X X | 17 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 58 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | Adenocarcinoma | X | 2 | Fibroadenoma | X X | 18 | Fibroadenoma, Multiple | X | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Lipoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| | | DAY ON TEST | 3| 3| 6| 3| 3| 2| 8| 0| 4| 3| | | | 1| 1| 1| 1| 1| 4| 0| 0| 9| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 240MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 59 | Carcinoma, Metastatic, Kidney | | 1 | Leukemia Mononuclear | X X X X X | 12 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 6 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 8 | Renal Tubule, Adenoma | | 1 | Transitional Epithelium, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X X | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 240MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | 13HUCC F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | M + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M M + + + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 240MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | 13HUCC F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 6| 6| 5| 7| 5| 7| 4| 4| 4| 5| 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 6| DAY ON TEST | 1| 2| 2| 2| 9| 7| 0| 2| 3| 2| 5| 5| 5| 4| 2| 2| 2| 2| 3| 5| 3| 5| 2| 3| 8| | 0| 9| 1| 9| 6| 0| 0| 9| 3| 9| 6| 6| 6| 3| 9| 9| 9| 9| 7| 7| 0| 7| 3| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Mesentery | + + + + + + + + + +| Mesothelioma Benign | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Acinus, Adenoma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + M + + +| Carcinoma | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X | Pars Distalis, Carcinoma | X | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 6| 6| 5| 7| 5| 7| 4| 4| 4| 5| 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 6| DAY ON TEST | 1| 2| 2| 2| 9| 7| 0| 2| 3| 2| 5| 5| 5| 4| 2| 2| 2| 2| 3| 5| 3| 5| 2| 3| 8| | 0| 9| 1| 9| 6| 0| 0| 9| 3| 9| 6| 6| 6| 3| 9| 9| 9| 9| 7| 7| 0| 7| 3| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Benign | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Benign | X X | Sertoli Cell Tumor Benign | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | | Mediastinal, Carcinoma Adenosquamous,| | Metastatic, Lung | | Mediastinal, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Thymus | + + + M + + + + + + + + I + + M + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 6| 6| 5| 7| 5| 7| 4| 4| 4| 5| 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 6| DAY ON TEST | 1| 2| 2| 2| 9| 7| 0| 2| 3| 2| 5| 5| 5| 4| 2| 2| 2| 2| 3| 5| 3| 5| 2| 3| 8| | 0| 9| 1| 9| 6| 0| 0| 9| 3| 9| 6| 6| 6| 3| 9| 9| 9| 9| 7| 7| 0| 7| 3| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + M + M + + + + + M + + + + + M M + M + + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basosquamous Tumor Malignant | | Keratoacanthoma | X X X X X| Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + | Fibrosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Benign | | Carcinoma, Metastatic, Pituitary | | Gland | X | Leukemia Mononuclear | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | Chordoma | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X X | Carcinoma Adenosquamous | | Chordoma, Metastatic, Spinal Cord | X | Chordoma, Metastatic, Uncertain | | Primary Site | | Leukemia Mononuclear | X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 6| 6| 5| 7| 5| 7| 4| 4| 4| 5| 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 6| DAY ON TEST | 1| 2| 2| 2| 9| 7| 0| 2| 3| 2| 5| 5| 5| 4| 2| 2| 2| 2| 3| 5| 3| 5| 2| 3| 8| | 0| 9| 1| 9| 6| 0| 0| 9| 3| 9| 6| 6| 6| 3| 9| 9| 9| 9| 7| 7| 0| 7| 3| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| Transitional Epithelium, Papilloma | X| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| Mesothelioma Benign | X X | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 4| 4| 7| 7| 0| 6| 4| 6| 4| 6| 7| 7| 4| 7| 6| 6| 6| 7| 7| 7| 4| 6| 4| DAY ON TEST | 3| 3| 5| 5| 3| 3| 2| 9| 5| 8| 6| 2| 2| 3| 5| 3| 8| 6| 2| 1| 3| 2| 6| 5| 5| | 0| 0| 6| 7| 0| 0| 5| 5| 6| 7| 5| 4| 2| 0| 7| 0| 7| 0| 4| 1| 1| 6| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 0MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Mesentery | + + | Mesothelioma Benign | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Acinus, Adenoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Carcinoma | | __________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X | Pars Distalis, Carcinoma | X | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 4| 4| 7| 7| 0| 6| 4| 6| 4| 6| 7| 7| 4| 7| 6| 6| 6| 7| 7| 7| 4| 6| 4| DAY ON TEST | 3| 3| 5| 5| 3| 3| 2| 9| 5| 8| 6| 2| 2| 3| 5| 3| 8| 6| 2| 1| 3| 2| 6| 5| 5| | 0| 0| 6| 7| 0| 0| 5| 5| 6| 7| 5| 4| 2| 0| 7| 0| 7| 0| 4| 1| 1| 6| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 0MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X X | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Benign | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Adenoma | X X | Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Benign | | Sertoli Cell Tumor Benign | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | X | Mediastinal, Carcinoma Adenosquamous,| | Metastatic, Lung | X | Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 4| 4| 7| 7| 0| 6| 4| 6| 4| 6| 7| 7| 4| 7| 6| 6| 6| 7| 7| 7| 4| 6| 4| DAY ON TEST | 3| 3| 5| 5| 3| 3| 2| 9| 5| 8| 6| 2| 2| 3| 5| 3| 8| 6| 2| 1| 3| 2| 6| 5| 5| | 0| 0| 6| 7| 0| 0| 5| 5| 6| 7| 5| 4| 2| 0| 7| 0| 7| 0| 4| 1| 1| 6| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 0MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + M + M M + + M + M + + + M M M + M| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basosquamous Tumor Malignant | | Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Fibrosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Benign | | Carcinoma, Metastatic, Pituitary | | Gland | X | Leukemia Mononuclear | X | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + + | Chordoma | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Carcinoma Adenosquamous | X | Chordoma, Metastatic, Spinal Cord | | Chordoma, Metastatic, Uncertain | | Primary Site | X | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Pinna, Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 4| 4| 7| 7| 0| 6| 4| 6| 4| 6| 7| 7| 4| 7| 6| 6| 6| 7| 7| 7| 4| 6| 4| DAY ON TEST | 3| 3| 5| 5| 3| 3| 2| 9| 5| 8| 6| 2| 2| 3| 5| 3| 8| 6| 2| 1| 3| 2| 6| 5| 5| | 0| 0| 6| 7| 0| 0| 5| 5| 6| 7| 5| 4| 2| 0| 7| 0| 7| 0| 4| 1| 1| 6| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 0MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| Transitional Epithelium, Papilloma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Mesothelioma Benign | | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 7| 7| 7| 7| 1| | | DAY ON TEST | 5| 3| 3| 2| 3| 3| 3| 3| 3| 9| | | | 7| 1| 1| 4| 8| 1| 1| 1| 1| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + A | 59 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A | 59 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A | 58 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A | 59 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 10 | __________________________________________________________________________|____________| Mesentery | + + | 14 | Mesothelioma Benign | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + A | 59 | Leukemia Mononuclear | X | 1 | Acinus, Adenoma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + A | 59 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + A | 59 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + A | 59 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 5 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X | 12 | Bilateral, Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + A | 59 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + A | 56 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 7| 7| 7| 7| 1| | | DAY ON TEST | 5| 3| 3| 2| 3| 3| 3| 3| 3| 9| | | | 7| 1| 1| 4| 8| 1| 1| 1| 1| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Carcinoma | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + A | 58 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X | 18 | Pars Distalis, Carcinoma | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + A | 58 | Bilateral, C-Cell, Adenoma | | 1 | C-Cell, Adenoma | X X X X | 8 | C-Cell, Carcinoma | X | 3 | Follicular Cell, Adenoma | | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Mesothelioma Benign | X | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 59 | Adenoma | X X | 7 | Carcinoma | | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Mesothelioma Benign | X X | 4 | Sertoli Cell Tumor Benign | X | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X | 35 | Interstitial Cell, Adenoma | X X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | Deep Cervical, Carcinoma, Metastatic,| | | Thyroid Gland | | 1 | Mediastinal, Carcinoma Adenosquamous,| | | Metastatic, Lung | | 1 | Mediastinal, Leukemia Mononuclear | X | 2 | Pancreatic, Leukemia Mononuclear | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 7| 7| 7| 7| 1| | | DAY ON TEST | 5| 3| 3| 2| 3| 3| 3| 3| 3| 9| | | | 7| 1| 1| 4| 8| 1| 1| 1| 1| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + A | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 10 | __________________________________________________________________________|____________| Thymus | + + + + + M + + + A | 54 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + M + M | 42 | Fibroadenoma | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + M + + | 59 | Basosquamous Tumor Malignant | X | 1 | Keratoacanthoma | | 6 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | + | 3 | Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Astrocytoma Benign | X | 1 | Carcinoma, Metastatic, Pituitary | | | Gland | | 2 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | | 2 | __________________________________________________________________________|____________| Spinal Cord | | 3 | Chordoma | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Carcinoma | | 2 | Carcinoma Adenosquamous | | 1 | Chordoma, Metastatic, Spinal Cord | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 7| 7| 7| 7| 1| | | DAY ON TEST | 5| 3| 3| 2| 3| 3| 3| 3| 3| 9| | | | 7| 1| 1| 4| 8| 1| 1| 1| 1| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Chordoma, Metastatic, Uncertain | | | Primary Site | | 1 | Leukemia Mononuclear | X | 9 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | Pinna, Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 8 | Renal Tubule, Adenoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Transitional Epithelium, Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 10 | Mesothelioma Benign | X X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | 13HUCC M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + | 9 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | 13HUCC M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M M M + M + + + | 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 6| 1| 4| 5| 4| 4| DAY ON TEST | 2| 5| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 2| 5| 5| 8| 5| 5| 0| 5| 5| | 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 9| 3| 0| 0| 3| 6| 6| 4| 8| 7| 9| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + | Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | | Polyp Adenomatous | | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + A + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + A + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + A + + + | Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + | Hepatocellular Adenoma | | Leukemia Mononuclear | X X X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Mesentery | + + + + + | Hemangioma | | Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | | Leukemia Mononuclear | X | Mesothelioma Benign | | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Pancreas | + + + + A + + + + + + + + + + + + A + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | Acinus, Adenoma, Multiple | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + | Leukemia Mononuclear | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 6| 1| 4| 5| 4| 4| DAY ON TEST | 2| 5| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 2| 5| 5| 8| 5| 5| 0| 5| 5| | 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 9| 3| 0| 0| 3| 6| 6| 4| 8| 7| 9| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mixed Tumor NOS | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + A + + + + + + + + + + + + A + + + | Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + | Adenoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + | C-Cell, Adenoma | X X X X X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + | Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + | Adenoma | X | Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + | Mesothelioma Malignant | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + A + + + | Mesothelioma Benign | | Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 6| 1| 4| 5| 4| 4| DAY ON TEST | 2| 5| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 2| 5| 5| 8| 5| 5| 0| 5| 5| | 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 9| 3| 0| 0| 3| 6| 6| 4| 8| 7| 9| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + | Mediastinal, Leukemia Mononuclear | X X | Mediastinal, Sarcoma, Metastatic, | | Uncertain Primary Site | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + M + | Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + A + + + | Fibrosarcoma | X | Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | | Leukemia Mononuclear | X X X | Mesothelioma Benign | | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Thymus | + + + + + + M + + M + + M + + + + + + + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + M M + + + M + + + + + + + + M + | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + | Basosquamous Tumor Malignant | | Keratoacanthoma | X | Squamous Cell Papilloma | X X X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Skeletal Muscle | + | Chordoma | X | Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 6| 1| 4| 5| 4| 4| DAY ON TEST | 2| 5| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 2| 5| 5| 8| 5| 5| 0| 5| 5| | 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 9| 3| 0| 0| 3| 6| 6| 4| 8| 7| 9| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + | Astrocytoma Malignant | X | Leukemia Mononuclear | | __________________________________________________________________________| Peripheral Nerve | + | Schwannoma Benign | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + | Papilloma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Benign | | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 4| 4| 7| 5| 7| 4| 7| 7| 7| 4| 7| 7| 0| 7| 7| 4| 6| 5| 7| 6| 6| 7| 5| 7| DAY ON TEST | 3| 5| 5| 3| 2| 3| 5| 3| 3| 1| 5| 1| 3| 3| 3| 3| 5| 3| 4| 3| 6| 5| 3| 6| 3| | 0| 7| 6| 0| 5| 0| 7| 0| 0| 9| 7| 3| 0| 2| 1| 1| 6| 1| 7| 1| 0| 9| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | X | Polyp Adenomatous | | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X| Leukemia Mononuclear | X X | Mesothelioma Malignant | | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Mesentery | + + + + + + | Hemangioma | | Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | X | Leukemia Mononuclear | | Mesothelioma Benign | X | Mesothelioma Malignant | | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Pancreas | + + A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Sarcoma, Metastatic, Uncertain | | Primary Site | X | Acinus, Adenoma, Multiple | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 4| 4| 7| 5| 7| 4| 7| 7| 7| 4| 7| 7| 0| 7| 7| 4| 6| 5| 7| 6| 6| 7| 5| 7| DAY ON TEST | 3| 5| 5| 3| 2| 3| 5| 3| 3| 1| 5| 1| 3| 3| 3| 3| 5| 3| 4| 3| 6| 5| 3| 6| 3| | 0| 7| 6| 0| 5| 0| 7| 0| 0| 9| 7| 3| 0| 2| 1| 1| 6| 1| 7| 1| 0| 9| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mixed Tumor NOS | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Benign | X | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 4| 4| 7| 5| 7| 4| 7| 7| 7| 4| 7| 7| 0| 7| 7| 4| 6| 5| 7| 6| 6| 7| 5| 7| DAY ON TEST | 3| 5| 5| 3| 2| 3| 5| 3| 3| 1| 5| 1| 3| 3| 3| 3| 5| 3| 4| 3| 6| 5| 3| 6| 3| | 0| 7| 6| 0| 5| 0| 7| 0| 0| 9| 7| 3| 0| 2| 1| 1| 6| 1| 7| 1| 0| 9| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | | Mediastinal, Sarcoma, Metastatic, | | Uncertain Primary Site | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | X | Leukemia Mononuclear | X X X | Mesothelioma Benign | X | Mesothelioma Malignant | | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + M +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + M + + +| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Basosquamous Tumor Malignant | | Keratoacanthoma | X X | Squamous Cell Papilloma | X X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + | Chordoma | | Leiomyosarcoma, Metastatic, | | Uncertain Primary Site | X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 4| 4| 7| 5| 7| 4| 7| 7| 7| 4| 7| 7| 0| 7| 7| 4| 6| 5| 7| 6| 6| 7| 5| 7| DAY ON TEST | 3| 5| 5| 3| 2| 3| 5| 3| 3| 1| 5| 1| 3| 3| 3| 3| 5| 3| 4| 3| 6| 5| 3| 6| 3| | 0| 7| 6| 0| 5| 0| 7| 0| 0| 9| 7| 3| 0| 2| 1| 1| 6| 1| 7| 1| 0| 9| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Leukemia Mononuclear | | __________________________________________________________________________| Peripheral Nerve | | Schwannoma Benign | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + +| Papilloma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Zymbal's Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Benign | X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 4| 7| 7| 6| 5| 7| | | DAY ON TEST | 1| 4| 6| 2| 5| 3| 3| 0| 2| 3| | | | 1| 3| 9| 5| 7| 1| 1| 3| 5| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + | 50 | Leiomyosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | Polyp Adenomatous | X | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + | 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + | 48 | Leiomyosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + | 51 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | X X | 7 | Mesothelioma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Mesentery | + + + | 14 | Hemangioma | X | 1 | Leiomyosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | Leukemia Mononuclear | X | 2 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 47 | Leukemia Mononuclear | X | 2 | Mesothelioma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | Acinus, Adenoma, Multiple | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 4| 7| 7| 6| 5| 7| | | DAY ON TEST | 1| 4| 6| 2| 5| 3| 3| 0| 2| 3| | | | 1| 3| 9| 5| 7| 1| 1| 3| 5| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + | 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Tooth | | 1 | Mixed Tumor NOS | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 2 | __________________________________________________________________________|____________| Heart | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + | 50 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 4 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + | 47 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M M + + | 47 | Adenoma | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + | 51 | Leukemia Mononuclear | X | 2 | Pars Distalis, Adenoma | X X X X | 12 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + | 50 | C-Cell, Adenoma | X | 10 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + M + + + + + + | 49 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + M + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 4| 7| 7| 6| 5| 7| | | DAY ON TEST | 1| 4| 6| 2| 5| 3| 3| 0| 2| 3| | | | 1| 3| 9| 5| 7| 1| 1| 3| 5| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Adenoma | | 4 | Carcinoma | X | 3 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + | 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Testes | + + M + + + + + + | 49 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X | 33 | Interstitial Cell, Adenoma | X | 9 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + | 50 | Mediastinal, Leukemia Mononuclear | X | 3 | Mediastinal, Sarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + | 50 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + | 48 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + | 49 | Fibrosarcoma | | 1 | Leiomyosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | Leukemia Mononuclear | X X X | 9 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + | 46 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + | 44 | Fibroadenoma | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + | 51 | Basosquamous Tumor Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 70 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 4| 7| 7| 6| 5| 7| | | DAY ON TEST | 1| 4| 6| 2| 5| 3| 3| 0| 2| 3| | | | 1| 3| 9| 5| 7| 1| 1| 3| 5| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Keratoacanthoma | X | 4 | Squamous Cell Papilloma | | 5 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 3 | Chordoma | | 1 | Leiomyosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + | 50 | Astrocytoma Malignant | | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | Schwannoma Benign | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 1 | Leukemia Mononuclear | X X | 7 | __________________________________________________________________________|____________| Nose | + + + + + + + + + | 50 | Papilloma | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 59 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 71 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 4| 7| 7| 6| 5| 7| | | DAY ON TEST | 1| 4| 6| 2| 5| 3| 3| 0| 2| 3| | | | 1| 3| 9| 5| 7| 1| 1| 3| 5| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | X X X | 9 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A | 30MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 13HUCC M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 7| 5| 5| 5| 7| 7| 4| 7| 4| 6| DAY ON TEST | 6| 6| 2| 2| 2| 5| 2| 2| 2| 6| 2| 2| 5| 9| 2| 2| 6| 2| 7| 3| 3| 5| 3| 5| 9| | 3| 2| 9| 3| 9| 7| 9| 9| 9| 8| 9| 9| 6| 2| 9| 9| 5| 1| 9| 0| 0| 7| 0| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 60MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Leiomyosarcoma | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Mesentery | + + | Carcinoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | | Acinus, Adenoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 7| 5| 5| 5| 7| 7| 4| 7| 4| 6| DAY ON TEST | 6| 6| 2| 2| 2| 5| 2| 2| 2| 6| 2| 2| 5| 9| 2| 2| 6| 2| 7| 3| 3| 5| 3| 5| 9| | 3| 2| 9| 3| 9| 7| 9| 9| 9| 8| 9| 9| 6| 2| 9| 9| 5| 1| 9| 0| 0| 7| 0| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 60MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Carcinoma | | C-Cell, Adenoma | | C-Cell, Carcinoma | X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Carcinoma, Metastatic, | | Uncertain Primary Site | | Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 7| 5| 5| 5| 7| 7| 4| 7| 4| 6| DAY ON TEST | 6| 6| 2| 2| 2| 5| 2| 2| 2| 6| 2| 2| 5| 9| 2| 2| 6| 2| 7| 3| 3| 5| 3| 5| 9| | 3| 2| 9| 3| 9| 7| 9| 9| 9| 8| 9| 9| 6| 2| 9| 9| 5| 1| 9| 0| 0| 7| 0| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 60MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + M + + + + + + + + M + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma, Multiple | X | Keratoacanthoma | X | Squamous Cell Carcinoma | | Squamous Cell Papilloma | | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Lipoma | X | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Preputial | | Gland | X | Carcinoma, Metastatic, Thyroid Gland | | Carcinoma, Metastatic, Uncertain | | Primary Site | | Leukemia Mononuclear | X X X X | Squamous Cell Carcinoma | | Squamous Cell Carcinoma, Multiple, | | Metastatic, Uncertain Primary | | Site | X | Mediastinum, Carcinoma, Metastatic, | | Thyroid Gland | | _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 7| 5| 5| 5| 7| 7| 4| 7| 4| 6| DAY ON TEST | 6| 6| 2| 2| 2| 5| 2| 2| 2| 6| 2| 2| 5| 9| 2| 2| 6| 2| 7| 3| 3| 5| 3| 5| 9| | 3| 2| 9| 3| 9| 7| 9| 9| 9| 8| 9| 9| 6| 2| 9| 9| 5| 1| 9| 0| 0| 7| 0| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 60MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 6| 3| 2| 7| 7| 0| 6| 7| 7| 7| 6| 1| 4| 6| 4| 6| 4| DAY ON TEST | 5| 6| 3| 3| 3| 2| 3| 3| 5| 1| 7| 0| 3| 6| 7| 3| 3| 3| 3| 9| 5| 6| 5| 6| 5| | 7| 1| 0| 0| 0| 6| 0| 1| 4| 9| 4| 1| 1| 1| 6| 1| 1| 1| 3| 7| 7| 1| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 60MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + | Carcinoma | X | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + A + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + A + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + | Carcinoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + A + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + A + + | Adenocarcinoma | X | Leiomyosarcoma | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Mesentery | + + + + | Carcinoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Pancreas | + + + + + + + + A + + + + + + + + + A + + | Carcinoma, Metastatic, Uncertain | | Primary Site | X | Acinus, Adenoma | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + A + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + | Carcinoma, Metastatic, Uncertain | | Primary Site | X | Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + | Carcinoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + | Adenoma | | Carcinoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 6| 3| 2| 7| 7| 0| 6| 7| 7| 7| 6| 1| 4| 6| 4| 6| 4| DAY ON TEST | 5| 6| 3| 3| 3| 2| 3| 3| 5| 1| 7| 0| 3| 6| 7| 3| 3| 3| 3| 9| 5| 6| 5| 6| 5| | 7| 1| 0| 0| 0| 6| 0| 1| 4| 9| 4| 1| 1| 1| 6| 1| 1| 1| 3| 7| 7| 1| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 60MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + A + + | Leukemia Mononuclear | | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X | Bilateral, Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + A + + + + + + + + + A + + | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + A + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + A + + + + + + + + + A + + | Bilateral, C-Cell, Carcinoma | X | C-Cell, Adenoma | X X X | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + A + + | Adenoma | | Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + | Carcinoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + A + + | Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + | Mediastinal, Carcinoma, Metastatic, | | Uncertain Primary Site | X | Mediastinal, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + A + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 6| 3| 2| 7| 7| 0| 6| 7| 7| 7| 6| 1| 4| 6| 4| 6| 4| DAY ON TEST | 5| 6| 3| 3| 3| 2| 3| 3| 5| 1| 7| 0| 3| 6| 7| 3| 3| 3| 3| 9| 5| 6| 5| 6| 5| | 7| 1| 0| 0| 0| 6| 0| 1| 4| 9| 4| 1| 1| 1| 6| 1| 1| 1| 3| 7| 7| 1| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 60MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + M | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + | Basal Cell Adenoma, Multiple | | Keratoacanthoma | X | Squamous Cell Carcinoma | X | Squamous Cell Papilloma | X | Sebaceous Gland, Adenoma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Lipoma | | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Preputial | | Gland | | Carcinoma, Metastatic, Thyroid Gland | X | Carcinoma, Metastatic, Uncertain | | Primary Site | X | Leukemia Mononuclear | X | Squamous Cell Carcinoma | | Squamous Cell Carcinoma, Multiple, | | Metastatic, Uncertain Primary | | Site | | Mediastinum, Carcinoma, Metastatic, | | Thyroid Gland | X | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 6| 3| 2| 7| 7| 0| 6| 7| 7| 7| 6| 1| 4| 6| 4| 6| 4| DAY ON TEST | 5| 6| 3| 3| 3| 2| 3| 3| 5| 1| 7| 0| 3| 6| 7| 3| 3| 3| 3| 9| 5| 6| 5| 6| 5| | 7| 1| 0| 0| 0| 6| 0| 1| 4| 9| 4| 1| 1| 1| 6| 1| 1| 1| 3| 7| 7| 1| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 60MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + A + + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 81 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 5| 7| 4| 7| 6| 3| 7| 4| 7| 5| | | DAY ON TEST | 5| 3| 5| 3| 9| 0| 3| 5| 3| 1| | | | 4| 1| 7| 1| 7| 6| 1| 6| 1| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 60MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 50 | Carcinoma | | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 49 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 48 | Adenocarcinoma | | 1 | Leiomyosarcoma | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 51 | Leukemia Mononuclear | X X | 8 | __________________________________________________________________________|____________| Mesentery | + | 7 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 48 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Acinus, Adenoma | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + M + + + + | 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + | 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 49 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 49 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + | 50 | Leukemia Mononuclear | X | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 5| 7| 4| 7| 6| 3| 7| 4| 7| 5| | | DAY ON TEST | 5| 3| 5| 3| 9| 0| 3| 5| 3| 1| | | | 4| 1| 7| 1| 7| 6| 1| 6| 1| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 60MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + | 50 | Adenoma | | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + | 49 | Leukemia Mononuclear | X | 5 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X | 6 | Bilateral, Pheochromocytoma Benign | | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 48 | Carcinoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M + + + + | 45 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 49 | Leukemia Mononuclear | X | 2 | Pars Distalis, Adenoma | X X | 18 | __________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + | 47 | Bilateral, C-Cell, Carcinoma | | 1 | C-Cell, Adenoma | X X | 5 | C-Cell, Carcinoma | | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + | 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + | 49 | Adenoma | | 2 | Carcinoma | | 3 | __________________________________________________________________________|____________| Prostate | + + + + + + + + | 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + | 50 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + | 51 | Bilateral, Interstitial Cell, Adenoma| X X X X | 29 | Interstitial Cell, Adenoma | X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 5| 7| 4| 7| 6| 3| 7| 4| 7| 5| | | DAY ON TEST | 5| 3| 5| 3| 9| 0| 3| 5| 3| 1| | | | 4| 1| 7| 1| 7| 6| 1| 6| 1| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 60MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 49 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 50 | Mediastinal, Carcinoma, Metastatic, | | | Uncertain Primary Site | | 1 | Mediastinal, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + | 48 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 50 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 50 | Leukemia Mononuclear | X X | 10 | __________________________________________________________________________|____________| Thymus | + + + M + + + + | 48 | Leukemia Mononuclear | X X | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M + + + M | 44 | Fibroadenoma | | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 50 | Basal Cell Adenoma, Multiple | | 1 | Keratoacanthoma | | 2 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | | 1 | Sebaceous Gland, Adenoma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Lipoma | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 5| 7| 4| 7| 6| 3| 7| 4| 7| 5| | | DAY ON TEST | 5| 3| 5| 3| 9| 0| 3| 5| 3| 1| | | | 4| 1| 7| 1| 7| 6| 1| 6| 1| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 60MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + | 50 | Alveolar/Bronchiolar Carcinoma | | 1 | Carcinoma, Metastatic, Preputial | | | Gland | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Leukemia Mononuclear | X X | 7 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Carcinoma, Multiple, | | | Metastatic, Uncertain Primary | | | Site | | 1 | Mediastinum, Carcinoma, Metastatic, | | | Thyroid Gland | | 1 | __________________________________________________________________________|____________| Nose | + + + + A + + + | 48 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 60MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | 13HUCC M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 86 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 1| 5| 4| 4| 7| 6| 5| 6| 7| 7| 3| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 4| 5| 5| 2| 8| 4| 9| 2| 2| 2| 2| 2| 4| 2| 2| 6| 2| 2| 1| 3| 3| 3| 3| | 9| 2| 3| 9| 7| 9| 7| 1| 4| 9| 9| 4| 7| 9| 8| 9| 9| 8| 9| 0| 9| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 120MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X | Sarcoma, Metastatic, Skin | | __________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Acinus, Adenoma, Multiple | X | __________________________________________________________________________| Pharynx | + | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X| Bilateral, Pheochromocytoma Malignant| X | _____________________________________________________________________________________________________________________| Page 87 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 1| 5| 4| 4| 7| 6| 5| 6| 7| 7| 3| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 4| 5| 5| 2| 8| 4| 9| 2| 2| 2| 2| 2| 4| 2| 2| 6| 2| 2| 1| 3| 3| 3| 3| | 9| 2| 3| 9| 7| 9| 7| 1| 4| 9| 9| 4| 7| 9| 8| 9| 9| 8| 9| 0| 9| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 120MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + M + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + + M + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 88 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 1| 5| 4| 4| 7| 6| 5| 6| 7| 7| 3| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 4| 5| 5| 2| 8| 4| 9| 2| 2| 2| 2| 2| 4| 2| 2| 6| 2| 2| 1| 3| 3| 3| 3| | 9| 2| 3| 9| 7| 9| 7| 1| 4| 9| 9| 4| 7| 9| 8| 9| 9| 8| 9| 0| 9| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 120MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | M M + + + + + M + M + + + + + M + + + + + + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Keratoacanthoma | | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Pinna, Squamous Cell Papilloma | | __________________________________________________________________________| Eye | + + + | __________________________________________________________________________| Zymbal's Gland | + + | Adenoma | X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Renal Tubule, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 89 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 4| 4| 4| 7| 6| 7| 4| 4| 7| 4| 5| 7| 7| 7| 7| 1| 6| 4| 7| 6| DAY ON TEST | 1| 3| 3| 5| 0| 5| 5| 5| 1| 9| 3| 3| 5| 1| 5| 2| 3| 3| 3| 3| 5| 4| 5| 3| 8| | 9| 0| 0| 6| 8| 6| 7| 7| 6| 5| 0| 1| 6| 7| 6| 7| 0| 1| 1| 1| 0| 1| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 120MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Acinus, Adenoma, Multiple | | __________________________________________________________________________| Pharynx | | Palate, Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Malignant| | _____________________________________________________________________________________________________________________| Page 90 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 4| 4| 4| 7| 6| 7| 4| 4| 7| 4| 5| 7| 7| 7| 7| 1| 6| 4| 7| 6| DAY ON TEST | 1| 3| 3| 5| 0| 5| 5| 5| 1| 9| 3| 3| 5| 1| 5| 2| 3| 3| 3| 3| 5| 4| 5| 3| 8| | 9| 0| 0| 6| 8| 6| 7| 7| 6| 5| 0| 1| 6| 7| 6| 7| 0| 1| 1| 1| 0| 1| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 120MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Bilateral, Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + M + M + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | X X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thymus | + M + + + + + + + + + + M + + + + + + M + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 91 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 5| 4| 4| 4| 7| 6| 7| 4| 4| 7| 4| 5| 7| 7| 7| 7| 1| 6| 4| 7| 6| DAY ON TEST | 1| 3| 3| 5| 0| 5| 5| 5| 1| 9| 3| 3| 5| 1| 5| 2| 3| 3| 3| 3| 5| 4| 5| 3| 8| | 9| 0| 0| 6| 8| 6| 7| 7| 6| 5| 0| 1| 6| 7| 6| 7| 0| 1| 1| 1| 0| 1| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 120MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + + + + + M M + M + + + + + M + + + + M + + + +| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Keratoacanthoma | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Pinna, Squamous Cell Papilloma | X | __________________________________________________________________________| Eye | + + + + | __________________________________________________________________________| Zymbal's Gland | | Adenoma | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Renal Tubule, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 92 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 0| 7| 5| 4| 0| 7| | | DAY ON TEST | 5| 6| 3| 3| 8| 3| 9| 5| 1| 3| | | | 6| 4| 1| 1| 0| 1| 1| 7| 3| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 120MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + A + | 59 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + A + | 57 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + A + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + A + | 58 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + A + | 59 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + | 59 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + A + | 57 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + | 59 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | X | 10 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Mesentery | + | 8 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + A + | 58 | Leukemia Mononuclear | | 2 | Acinus, Adenoma, Multiple | | 1 | __________________________________________________________________________|____________| Pharynx | | 1 | Palate, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + M + | 58 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + A + | 59 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 93 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 0| 7| 5| 4| 0| 7| | | DAY ON TEST | 5| 6| 3| 3| 8| 3| 9| 5| 1| 3| | | | 6| 4| 1| 1| 0| 1| 1| 7| 3| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 120MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + M + | 59 | Leukemia Mononuclear | | 3 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X | 9 | Bilateral, Pheochromocytoma Malignant| | 1 | Bilateral, Pheochromocytoma Benign | | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + A + | 59 | Carcinoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M M | 53 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | Pars Distalis, Adenoma | X | 13 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + M + | 59 | Leukemia Mononuclear | | 1 | C-Cell, Adenoma | | 4 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 60 | Adenoma | | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Bilateral, Interstitial Cell, Adenoma| X X X X X X | 32 | Interstitial Cell, Adenoma | X | 14 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + A + | 59 | Mediastinal, Leukemia Mononuclear | | 4 | Pancreatic, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 94 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 0| 7| 5| 4| 0| 7| | | DAY ON TEST | 5| 6| 3| 3| 8| 3| 9| 5| 1| 3| | | | 6| 4| 1| 1| 0| 1| 1| 7| 3| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 120MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M + | 58 | Leukemia Mononuclear | | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + A M | 57 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + A + | 59 | Leukemia Mononuclear | X | 9 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 55 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M + + + + M + + + | 48 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basal Cell Adenoma | | 1 | Keratoacanthoma | | 1 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 2 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + M + | 59 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | Pinna, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Eye | | 7 | __________________________________________________________________________|____________| Zymbal's Gland | | 2 | Adenoma | | 1 | Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 95 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 0| 7| 5| 4| 0| 7| | | DAY ON TEST | 5| 6| 3| 3| 8| 3| 9| 5| 1| 3| | | | 6| 4| 1| 1| 0| 1| 1| 7| 3| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 120MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + A + | 59 | Leukemia Mononuclear | X | 8 | Renal Tubule, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + A + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 96 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 120MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 13HUCC M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Mesentery | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Testes | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 97 NTP Experiment-Test: 05086-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:34:19 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| | | | 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 120MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 13HUCC M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + M M + + M + + | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + + + + M M + | 6 | __________________________________________________________________________|____________| Skin | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Nose | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + | 9 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 98 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
Web page last updated on November 12, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.