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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 Facility: Battelle Columbus Laboratory Chemical CAS #: 120-32-1 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 0| 7| 4| 6| DAY ON TEST | 9| 2| 2| 2| 2| 2| 5| 2| 9| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 2| 9| 2| 5| 9| | 3| 2| 2| 2| 2| 4| 5| 4| 3| 5| 4| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 3| 7| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X X X| Hepatocellular Adenoma, Multiple | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | + | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 0| 7| 4| 6| DAY ON TEST | 9| 2| 2| 2| 2| 2| 5| 2| 9| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 2| 9| 2| 5| 9| | 3| 2| 2| 2| 2| 4| 5| 4| 3| 5| 4| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 3| 7| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M M + M + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Follicle, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | X | Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Teratoma | | Thecoma Benign | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Leiomyoma | | Lymphoma Malignant Lymphocytic | | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Deep Cervical, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant Mixed| X | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + M + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 0| 7| 4| 6| DAY ON TEST | 9| 2| 2| 2| 2| 2| 5| 2| 9| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 2| 9| 2| 5| 9| | 3| 2| 2| 2| 2| 4| 5| 4| 3| 5| 4| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 3| 7| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + M M + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | Thymoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Hemangioma | | Subcutaneous Tissue, Lymphoma | | Malignant Lymphocytic | | Subcutaneous Tissue, | | Neurofibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Lymphoma Malignant Lymphocytic | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X X| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Rhabdomyosarcoma, Metastatic, | | Skeletal Muscle | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 0| 7| 4| 6| DAY ON TEST | 9| 2| 2| 2| 2| 2| 5| 2| 9| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 2| 9| 2| 5| 9| | 3| 2| 2| 2| 2| 4| 5| 4| 3| 5| 4| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 3| 7| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | + + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 0| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 0| 4| 4| 7| 7| 0| 7| 7| DAY ON TEST | 2| 1| 0| 9| 2| 9| 9| 0| 2| 5| 9| 5| 2| 2| 2| 1| 2| 9| 5| 5| 2| 2| 9| 2| 2| | 7| 3| 6| 3| 7| 3| 2| 3| 8| 6| 9| 0| 8| 8| 8| 9| 8| 3| 6| 5| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X X X| Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | + | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 0| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 0| 4| 4| 7| 7| 0| 7| 7| DAY ON TEST | 2| 1| 0| 9| 2| 9| 9| 0| 2| 5| 9| 5| 2| 2| 2| 1| 2| 9| 5| 5| 2| 2| 9| 2| 2| | 7| 3| 6| 3| 7| 3| 2| 3| 8| 6| 9| 0| 8| 8| 8| 9| 8| 3| 6| 5| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Follicle, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Teratoma | | Thecoma Benign | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Leiomyoma | | Lymphoma Malignant Lymphocytic | | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Deep Cervical, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant Mixed| | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + M + + + + + + + + + + + M + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 0| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 0| 4| 4| 7| 7| 0| 7| 7| DAY ON TEST | 2| 1| 0| 9| 2| 9| 9| 0| 2| 5| 9| 5| 2| 2| 2| 1| 2| 9| 5| 5| 2| 2| 9| 2| 2| | 7| 3| 6| 3| 7| 3| 2| 3| 8| 6| 9| 0| 8| 8| 8| 9| 8| 3| 6| 5| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | Thymoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Hemangioma | | Subcutaneous Tissue, Lymphoma | | Malignant Lymphocytic | | Subcutaneous Tissue, | | Neurofibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Lymphoma Malignant Lymphocytic | | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Rhabdomyosarcoma, Metastatic, | | Skeletal Muscle | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 0| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 0| 4| 4| 7| 7| 0| 7| 7| DAY ON TEST | 2| 1| 0| 9| 2| 9| 9| 0| 2| 5| 9| 5| 2| 2| 2| 1| 2| 9| 5| 5| 2| 2| 9| 2| 2| | 7| 3| 6| 3| 7| 3| 2| 3| 8| 6| 9| 0| 8| 8| 8| 9| 8| 3| 6| 5| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 4| 7| 6| 0| 7| 6| 7| 7| 7| 5| 4| 4| 7| 7| 7| 7| 0| | | DAY ON TEST | 9| 2| 2| 5| 2| 4| 9| 0| 4| 2| 2| 2| 6| 5| 5| 2| 2| 2| 2| 9| | | | 3| 9| 5| 6| 9| 5| 3| 7| 0| 9| 9| 9| 0| 5| 5| 9| 9| 9| 9| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A | 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + A + + + M + + + | 67 | Lymphoma Malignant Lymphocytic | X X | 2 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + | 69 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A M + + + + + + | 67 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + | 69 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Hepatocellular Carcinoma | | 2 | Hepatocellular Adenoma | X X | 9 | Hepatocellular Adenoma, Multiple | X | 2 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 4 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Mesentery | + + + | 5 | Lymphoma Malignant Lymphocytic | X X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + M + + + + + + | 69 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 4| 7| 6| 0| 7| 6| 7| 7| 7| 5| 4| 4| 7| 7| 7| 7| 0| | | DAY ON TEST | 9| 2| 2| 5| 2| 4| 9| 0| 4| 2| 2| 2| 6| 5| 5| 2| 2| 2| 2| 9| | | | 3| 9| 5| 6| 9| 5| 3| 7| 0| 9| 9| 9| 0| 5| 5| 9| 9| 9| 9| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A | 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + + + + M M + + + M + | 61 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + M + + + + + + + + + + + | 67 | Pars Distalis, Adenoma | X X | 8 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + | 69 | Lymphoma Malignant Lymphocytic | X | 1 | Follicle, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + M + + | 69 | Granulosa Cell Tumor Benign | X | 2 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 2 | Teratoma | X | 1 | Thecoma Benign | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | X | 1 | Leiomyoma | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Polyp Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + M + + + + + + + + + + + + + + + + + | 69 | Deep Cervical, Lymphoma Malignant | | | Lymphocytic | X | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 4| 7| 6| 0| 7| 6| 7| 7| 7| 5| 4| 4| 7| 7| 7| 7| 0| | | DAY ON TEST | 9| 2| 2| 5| 2| 4| 9| 0| 4| 2| 2| 2| 6| 5| 5| 2| 2| 2| 2| 9| | | | 3| 9| 5| 6| 9| 5| 3| 7| 0| 9| 9| 9| 0| 5| 5| 9| 9| 9| 9| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A | 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Mediastinal, Lymphoma Malignant Mixed| X | 2 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Pancreatic, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + + + M + + + + + + + | 66 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + M + + + M + + + + M + + | 61 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 4 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + + + + M + | 65 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | Thymoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M + + + + + + + + + M + + + + + + | 65 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Subcutaneous Tissue, Fibrosarcoma | X X | 3 | Subcutaneous Tissue, Hemangioma | X | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant Lymphocytic | X | 1 | Subcutaneous Tissue, | | | Neurofibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Skeletal Muscle | + | 2 | Lymphoma Malignant Lymphocytic | X | 1 | Rhabdomyosarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 4| 7| 6| 0| 7| 6| 7| 7| 7| 5| 4| 4| 7| 7| 7| 7| 0| | | DAY ON TEST | 9| 2| 2| 5| 2| 4| 9| 0| 4| 2| 2| 2| 6| 5| 5| 2| 2| 2| 2| 9| | | | 3| 9| 5| 6| 9| 5| 3| 7| 0| 9| 9| 9| 0| 5| 5| 9| 9| 9| 9| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A | 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + M + | 69 | Alveolar/Bronchiolar Adenoma | X | 3 | Alveolar/Bronchiolar Carcinoma | | 2 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | Rhabdomyosarcoma, Metastatic, | | | Skeletal Muscle | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Harderian Gland | | 5 | Adenoma | | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 5 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 6| 7| 4| 0| 4| 0| 0| 4| 7| 7| 7| 7| 0| 0| 0| 4| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 2| 2| 9| 2| 5| 9| 5| 1| 9| 5| 2| 2| 2| 2| 1| 9| 9| 5| 2| 2| 2| 2| 2| | 5| 6| 2| 2| 7| 2| 6| 3| 5| 7| 3| 5| 2| 2| 2| 2| 0| 3| 3| 6| 2| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, Ear| | Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X| Hepatocellular Adenoma, Multiple | X X X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | Mast Cell Tumor Malignant, | | Metastatic, Mesentery | X | __________________________________________________________________________| Mesentery | + + | Hemangioma | | Hemangiosarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | Mast Cell Tumor Malignant | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + +| Adenocarcinoma | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 6| 7| 4| 0| 4| 0| 0| 4| 7| 7| 7| 7| 0| 0| 0| 4| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 2| 2| 9| 2| 5| 9| 5| 1| 9| 5| 2| 2| 2| 2| 1| 9| 9| 5| 2| 2| 2| 2| 2| | 5| 6| 2| 2| 7| 2| 6| 3| 5| 7| 3| 5| 2| 2| 2| 2| 0| 3| 3| 6| 2| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + +| Capsule, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | Follicle, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | Bilateral, Hemangiosarcoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Leiomyoma | | Leiomyosarcoma | X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 6| 7| 4| 0| 4| 0| 0| 4| 7| 7| 7| 7| 0| 0| 0| 4| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 2| 2| 9| 2| 5| 9| 5| 1| 9| 5| 2| 2| 2| 2| 1| 9| 9| 5| 2| 2| 2| 2| 2| | 5| 6| 2| 2| 7| 2| 6| 3| 5| 7| 3| 5| 2| 2| 2| 2| 0| 3| 3| 6| 2| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant, | | Metastatic, Mesentery | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + +| Inguinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Lumbar, Lymphoma Malignant | | Undifferentiated Cell Type | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + M + + + +| Fibrous Histiocytoma, Metastatic, Ear| | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | Mast Cell Tumor Malignant, | | Metastatic, Mesentery | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X X | Mast Cell Tumor Malignant, | | Metastatic, Mesentery | X | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 6| 7| 4| 0| 4| 0| 0| 4| 7| 7| 7| 7| 0| 0| 0| 4| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 2| 2| 9| 2| 5| 9| 5| 1| 9| 5| 2| 2| 2| 2| 1| 9| 9| 5| 2| 2| 2| 2| 2| | 5| 6| 2| 2| 7| 2| 6| 3| 5| 7| 3| 5| 2| 2| 2| 2| 0| 3| 3| 6| 2| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Cell Type | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Lymphoma | | Malignant Histiocytic | X | Subcutaneous Tissue, Lymphoma | | Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrous Histiocytoma | | __________________________________________________________________________| Harderian Gland | | Adenoma | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 6| 7| 4| 0| 4| 0| 0| 4| 7| 7| 7| 7| 0| 0| 0| 4| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 2| 2| 9| 2| 5| 9| 5| 1| 9| 5| 2| 2| 2| 2| 1| 9| 9| 5| 2| 2| 2| 2| 2| | 5| 6| 2| 2| 7| 2| 6| 3| 5| 7| 3| 5| 2| 2| 2| 2| 0| 3| 3| 6| 2| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X X | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 6| 5| 7| 6| 4| 6| 7| 7| 0| 7| 7| 0| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 9| 2| 6| 1| 2| 0| 5| 9| 2| 2| 9| 2| 2| 9| 9| 9| 2| 2| 2| 2| 8| 2| 2| 2| 2| | 3| 4| 4| 0| 4| 0| 5| 2| 4| 4| 3| 7| 7| 3| 3| 3| 7| 7| 7| 7| 8| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 120 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + A + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, Ear| | Hepatocellular Carcinoma | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | Mast Cell Tumor Malignant, | | Metastatic, Mesentery | | __________________________________________________________________________| Mesentery | + + + + | Hemangioma | | Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | Mast Cell Tumor Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Squamous Cell Papilloma | X X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 6| 5| 7| 6| 4| 6| 7| 7| 0| 7| 7| 0| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 9| 2| 6| 1| 2| 0| 5| 9| 2| 2| 9| 2| 2| 9| 9| 9| 2| 2| 2| 2| 8| 2| 2| 2| 2| | 3| 4| 4| 0| 4| 0| 5| 2| 4| 4| 3| 7| 7| 3| 3| 3| 7| 7| 7| 7| 8| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 120 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + +| Capsule, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | Follicle, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | Bilateral, Hemangiosarcoma | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Leiomyoma | X| Leiomyosarcoma | X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 6| 5| 7| 6| 4| 6| 7| 7| 0| 7| 7| 0| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 9| 2| 6| 1| 2| 0| 5| 9| 2| 2| 9| 2| 2| 9| 9| 9| 2| 2| 2| 2| 8| 2| 2| 2| 2| | 3| 4| 4| 0| 4| 0| 5| 2| 4| 4| 3| 7| 7| 3| 3| 3| 7| 7| 7| 7| 8| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 120 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant, | | Metastatic, Mesentery | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + +| Inguinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Lumbar, Lymphoma Malignant | | Undifferentiated Cell Type | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Lymph Node, Mandibular | M + + + + M + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, Ear| | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | Mast Cell Tumor Malignant, | | Metastatic, Mesentery | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | Mast Cell Tumor Malignant, | | Metastatic, Mesentery | | __________________________________________________________________________| Thymus | + + + + + M M + + + + + + M + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + M + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 6| 5| 7| 6| 4| 6| 7| 7| 0| 7| 7| 0| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 9| 2| 6| 1| 2| 0| 5| 9| 2| 2| 9| 2| 2| 9| 9| 9| 2| 2| 2| 2| 8| 2| 2| 2| 2| | 3| 4| 4| 0| 4| 0| 5| 2| 4| 4| 3| 7| 7| 3| 3| 3| 7| 7| 7| 7| 8| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 120 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Cell Type | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Lymphoma | | Malignant Histiocytic | | Subcutaneous Tissue, Lymphoma | | Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrous Histiocytoma | | __________________________________________________________________________| Harderian Gland | + + + | Adenoma | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 6| 5| 7| 6| 4| 6| 7| 7| 0| 7| 7| 0| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 9| 2| 6| 1| 2| 0| 5| 9| 2| 2| 9| 2| 2| 9| 9| 9| 2| 2| 2| 2| 8| 2| 2| 2| 2| | 3| 4| 4| 0| 4| 0| 5| 2| 4| 4| 3| 7| 7| 3| 3| 3| 7| 7| 7| 7| 8| 7| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 120 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 4| 0| 7| 0| 4| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 1| 2| 9| 5| 5| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| | | | 8| 6| 4| 8| 3| 5| 6| 8| 8| 8| 8| 9| 9| 9| 8| 9| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Gallbladder | + M + + + + + + + + + + + + + + | 47 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + | 50 | Fibrous Histiocytoma, Metastatic, Ear| X | 1 | Hepatocellular Carcinoma | | 1 | Hepatocellular Adenoma | X X X X X X | 9 | Hepatocellular Adenoma, Multiple | X | 5 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | Mast Cell Tumor Malignant, | | | Metastatic, Mesentery | | 1 | __________________________________________________________________________|____________| Mesentery | + + | 8 | Hemangioma | X | 1 | Hemangiosarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | Mast Cell Tumor Malignant | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + | 51 | Adenocarcinoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 4| 0| 7| 0| 4| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 1| 2| 9| 5| 5| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| | | | 8| 6| 4| 8| 3| 5| 6| 8| 8| 8| 8| 9| 9| 9| 8| 9| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + | 51 | Lymphoma Malignant Lymphocytic | | 1 | Squamous Cell Papilloma | | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + | 51 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + | 50 | Hemangiosarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + | 50 | Capsule, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + | 50 | Pars Distalis, Adenoma | X | 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Follicle, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + M + + + + + + | 49 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 4| 0| 7| 0| 4| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 1| 2| 9| 5| 5| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| | | | 8| 6| 4| 8| 3| 5| 6| 8| 8| 8| 8| 9| 9| 9| 8| 9| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cell Type | X | 2 | Bilateral, Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + | 52 | Hemangiosarcoma | X | 1 | Leiomyoma | | 1 | Leiomyosarcoma | | 2 | Lymphoma Malignant Histiocytic | X X | 2 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | Polyp Stromal | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + | 50 | Mast Cell Tumor Malignant, | | | Metastatic, Mesentery | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + | 50 | Inguinal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Lumbar, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 2 | Pancreatic, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + | 47 | Fibrous Histiocytoma, Metastatic, Ear| X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + + + + + M + + + + + | 48 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | Mast Cell Tumor Malignant, | | | Metastatic, Mesentery | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 4| 0| 7| 0| 4| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 1| 2| 9| 5| 5| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| | | | 8| 6| 4| 8| 3| 5| 6| 8| 8| 8| 8| 9| 9| 9| 8| 9| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + | 50 | Hemangiosarcoma | X | 2 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 4 | Mast Cell Tumor Malignant, | | | Metastatic, Mesentery | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + + M | 44 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + | 49 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + | 50 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | X | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant Histiocytic | | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 1 | Alveolar/Bronchiolar Carcinoma | X | 2 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 4| 0| 7| 0| 4| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 1| 2| 9| 5| 5| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| | | | 8| 6| 4| 8| 3| 5| 6| 8| 8| 8| 8| 9| 9| 9| 8| 9| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | Pinna, Fibrous Histiocytoma | X | 1 | __________________________________________________________________________|____________| Harderian Gland | | 3 | Adenoma | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Histiocytic | X X | 3 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 4| 4| 4| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 0| 7| 7| 7| 6| 7| 0| 0| 7| DAY ON TEST | 2| 5| 5| 8| 2| 9| 2| 0| 2| 2| 2| 2| 2| 2| 5| 9| 9| 2| 2| 1| 6| 2| 9| 9| 1| | 2| 5| 6| 2| 2| 3| 2| 7| 2| 2| 2| 2| 4| 4| 6| 3| 3| 4| 4| 4| 8| 4| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | X | Hepatocellular Carcinoma | X X| Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X X X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Mesentery | + + | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 4| 4| 4| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 0| 7| 7| 7| 6| 7| 0| 0| 7| DAY ON TEST | 2| 5| 5| 8| 2| 9| 2| 0| 2| 2| 2| 2| 2| 2| 5| 9| 9| 2| 2| 1| 6| 2| 9| 9| 1| | 2| 5| 6| 2| 2| 3| 2| 7| 2| 2| 2| 2| 4| 4| 6| 3| 3| 4| 4| 4| 8| 4| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + M M + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + M + + + + + + + + + + + + M| Pars Distalis, Adenoma | X X | Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + M| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + +| Leiomyoma | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Vagina | | Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + +| Mediastinal, Lymphoma Malignant | | Histiocytic | | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 4| 4| 4| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 0| 7| 7| 7| 6| 7| 0| 0| 7| DAY ON TEST | 2| 5| 5| 8| 2| 9| 2| 0| 2| 2| 2| 2| 2| 2| 5| 9| 9| 2| 2| 1| 6| 2| 9| 9| 1| | 2| 5| 6| 2| 2| 3| 2| 7| 2| 2| 2| 2| 4| 4| 6| 3| 3| 4| 4| 4| 8| 4| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | X | Renal, Lymphoma Malignant Histiocytic| | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M M + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + M| Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + +| Meningioma Malignant | X | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 4| 4| 4| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 0| 7| 7| 7| 6| 7| 0| 0| 7| DAY ON TEST | 2| 5| 5| 8| 2| 9| 2| 0| 2| 2| 2| 2| 2| 2| 5| 9| 9| 2| 2| 1| 6| 2| 9| 9| 1| | 2| 5| 6| 2| 2| 3| 2| 7| 2| 2| 2| 2| 4| 4| 6| 3| 3| 4| 4| 4| 8| 4| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 0| 6| 7| 4| 7| 4| 0| 7| 7| 4| 7| 7| 7| 0| 4| 1| 6| 6| 0| 4| 6| 7| 7| 7| DAY ON TEST | 9| 9| 8| 2| 5| 2| 5| 9| 2| 2| 5| 2| 0| 2| 0| 5| 9| 7| 5| 0| 4| 9| 2| 2| 2| | 3| 3| 5| 4| 5| 4| 6| 3| 7| 7| 6| 7| 6| 7| 7| 6| 6| 8| 2| 7| 9| 1| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 240 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | | Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant Histiocytic | X X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 0| 6| 7| 4| 7| 4| 0| 7| 7| 4| 7| 7| 7| 0| 4| 1| 6| 6| 0| 4| 6| 7| 7| 7| DAY ON TEST | 9| 9| 8| 2| 5| 2| 5| 9| 2| 2| 5| 2| 0| 2| 0| 5| 9| 7| 5| 0| 4| 9| 2| 2| 2| | 3| 3| 5| 4| 5| 4| 6| 3| 7| 7| 6| 7| 6| 7| 7| 6| 6| 8| 2| 7| 9| 1| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 240 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | Lymphoma Malignant Histiocytic | X X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Vagina | + | Lymphoma Malignant Histiocytic | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + M + + + + M + + +| Mediastinal, Lymphoma Malignant | | Histiocytic | | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 0| 6| 7| 4| 7| 4| 0| 7| 7| 4| 7| 7| 7| 0| 4| 1| 6| 6| 0| 4| 6| 7| 7| 7| DAY ON TEST | 9| 9| 8| 2| 5| 2| 5| 9| 2| 2| 5| 2| 0| 2| 0| 5| 9| 7| 5| 0| 4| 9| 2| 2| 2| | 3| 3| 5| 4| 5| 4| 6| 3| 7| 7| 6| 7| 6| 7| 7| 6| 6| 8| 2| 7| 9| 1| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 240 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | | Renal, Lymphoma Malignant Histiocytic| X | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + M + + M + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + M + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + M + + M| Lymphoma Malignant Histiocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + +| Meningioma Malignant | | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 0| 6| 7| 4| 7| 4| 0| 7| 7| 4| 7| 7| 7| 0| 4| 1| 6| 6| 0| 4| 6| 7| 7| 7| DAY ON TEST | 9| 9| 8| 2| 5| 2| 5| 9| 2| 2| 5| 2| 0| 2| 0| 5| 9| 7| 5| 0| 4| 9| 2| 2| 2| | 3| 3| 5| 4| 5| 4| 6| 3| 7| 7| 6| 7| 6| 7| 7| 6| 6| 8| 2| 7| 9| 1| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 240 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X | Lymphoma Malignant Histiocytic | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 4| 7| 0| 7| 4| 7| 5| 4| 7| 0| 7| 7| 7| 7| 6| | | DAY ON TEST | 9| 2| 2| 2| 2| 5| 2| 9| 2| 5| 2| 6| 5| 2| 9| 2| 2| 2| 2| 2| | | | 2| 8| 8| 8| 8| 5| 8| 3| 8| 5| 9| 9| 5| 9| 3| 9| 9| 9| 9| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A | 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + | 51 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + | 51 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Intestine Small | M + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | M + + + + + + + + + + + + + | 48 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | M + + + + + + + + + + + + + | 48 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | M + + + + + + + + + + + + + | 48 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 50 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | Hepatocellular Carcinoma | | 3 | Hepatocellular Adenoma | X X X X X | 11 | Hepatocellular Adenoma, Multiple | X | 4 | Lymphoma Malignant Histiocytic | X | 3 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Mesentery | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 4| 7| 0| 7| 4| 7| 5| 4| 7| 0| 7| 7| 7| 7| 6| | | DAY ON TEST | 9| 2| 2| 2| 2| 5| 2| 9| 2| 5| 2| 6| 5| 2| 9| 2| 2| 2| 2| 2| | | | 2| 8| 8| 8| 8| 5| 8| 3| 8| 5| 9| 9| 5| 9| 3| 9| 9| 9| 9| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A | 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Histiocytic | | 1 | Squamous Cell Papilloma | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + | 49 | Lymphoma Malignant Histiocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + | 50 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + M + + | 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + M | 47 | Pars Distalis, Adenoma | X X X | 5 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 49 | Lymphoma Malignant Histiocytic | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + | 56 | Leiomyoma | X | 1 | Lymphoma Malignant Histiocytic | X | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Vagina | | 1 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 4| 7| 0| 7| 4| 7| 5| 4| 7| 0| 7| 7| 7| 7| 6| | | DAY ON TEST | 9| 2| 2| 2| 2| 5| 2| 9| 2| 5| 2| 6| 5| 2| 9| 2| 2| 2| 2| 2| | | | 2| 8| 8| 8| 8| 5| 8| 3| 8| 5| 9| 9| 5| 9| 3| 9| 9| 9| 9| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A | 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + | 50 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + | 48 | Mediastinal, Lymphoma Malignant | | | Histiocytic | X | 1 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Pancreatic, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Renal, Lymphoma Malignant Histiocytic| X | 2 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + | 46 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 46 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 50 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Histiocytic | X X | 3 | Lymphoma Malignant Mixed | X | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 3 | __________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + + | 44 | Lymphoma Malignant Histiocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + M + + + + + + + + + | 47 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 4| 7| 0| 7| 4| 7| 5| 4| 7| 0| 7| 7| 7| 7| 6| | | DAY ON TEST | 9| 2| 2| 2| 2| 5| 2| 9| 2| 5| 2| 6| 5| 2| 9| 2| 2| 2| 2| 2| | | | 2| 8| 8| 8| 8| 5| 8| 3| 8| 5| 9| 9| 5| 9| 3| 9| 9| 9| 9| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A | 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + | 50 | Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + | 50 | Meningioma Malignant | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 50 | Alveolar/Bronchiolar Carcinoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 3 | Adenoma | | 2 | Lymphoma Malignant Histiocytic | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + | 50 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Histiocytic | X X | 4 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 4| 7| 0| 7| 4| 7| 5| 4| 7| 0| 7| 7| 7| 7| 6| | | DAY ON TEST | 9| 2| 2| 2| 2| 5| 2| 9| 2| 5| 2| 6| 5| 2| 9| 2| 2| 2| 2| 2| | | | 2| 8| 8| 8| 8| 5| 8| 3| 8| 5| 9| 9| 5| 9| 3| 9| 9| 9| 9| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A | 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 5| 1| 4| 4| 0| 7| 7| 0| 7| 6| 4| 7| 0| 4| 7| 4| 7| 7| 0| 6| 7| 4| 0| 1| 7| DAY ON TEST | 2| 9| 5| 5| 9| 2| 2| 9| 2| 6| 5| 2| 9| 8| 2| 5| 2| 1| 9| 0| 2| 2| 9| 1| 2| | 1| 7| 5| 5| 3| 2| 2| 3| 0| 6| 5| 2| 3| 2| 2| 5| 2| 4| 3| 8| 4| 2| 3| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + + + M + + + + + + + + A + M + A + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 5| 1| 4| 4| 0| 7| 7| 0| 7| 6| 4| 7| 0| 4| 7| 4| 7| 7| 0| 6| 7| 4| 0| 1| 7| DAY ON TEST | 2| 9| 5| 5| 9| 2| 2| 9| 2| 6| 5| 2| 9| 8| 2| 5| 2| 1| 9| 0| 2| 2| 9| 1| 2| | 1| 7| 5| 5| 3| 2| 2| 3| 0| 6| 5| 2| 3| 2| 2| 5| 2| 4| 3| 8| 4| 2| 3| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Ovary | M + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Vagina | | Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Lymphoma Malignant | | Histiocytic | | Mediastinal, Lymphoma Malignant Mixed| | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + M + M + + M + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Thymus | M + + + + + + + + + + + + M + + + M + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + M + + M M + M + + + M +| __________________________________________________________________________| Skin | + + M + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Lymphoma | | Malignant Histiocytic | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 5| 1| 4| 4| 0| 7| 7| 0| 7| 6| 4| 7| 0| 4| 7| 4| 7| 7| 0| 6| 7| 4| 0| 1| 7| DAY ON TEST | 2| 9| 5| 5| 9| 2| 2| 9| 2| 6| 5| 2| 9| 8| 2| 5| 2| 1| 9| 0| 2| 2| 9| 1| 2| | 1| 7| 5| 5| 3| 2| 2| 3| 0| 6| 5| 2| 3| 2| 2| 5| 2| 4| 3| 8| 4| 2| 3| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Liver | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 7| 5| 6| 4| 7| 7| 6| 0| 0| 4| 7| 6| 0| 7| 4| 6| 4| 2| 4| 3| 7| 6| 7| 7| DAY ON TEST | 2| 2| 5| 5| 5| 0| 2| 5| 0| 9| 5| 2| 4| 9| 2| 5| 5| 5| 6| 3| 0| 2| 9| 2| 2| | 4| 4| 4| 1| 5| 7| 4| 2| 8| 3| 6| 7| 7| 3| 7| 6| 8| 6| 9| 7| 3| 7| 9| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 480 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + A + A + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X X X| Lymphoma Malignant Histiocytic | X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 7| 5| 6| 4| 7| 7| 6| 0| 0| 4| 7| 6| 0| 7| 4| 6| 4| 2| 4| 3| 7| 6| 7| 7| DAY ON TEST | 2| 2| 5| 5| 5| 0| 2| 5| 0| 9| 5| 2| 4| 9| 2| 5| 5| 5| 6| 3| 0| 2| 9| 2| 2| | 4| 4| 4| 1| 5| 7| 4| 2| 8| 3| 6| 7| 7| 3| 7| 6| 8| 6| 9| 7| 3| 7| 9| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 480 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Vagina | + | Lymphoma Malignant Histiocytic | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Lymphoma Malignant | | Histiocytic | X | Mediastinal, Lymphoma Malignant Mixed| X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + M + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Histiocytic | X X | __________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Lymphoma | | Malignant Histiocytic | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 7| 7| 5| 6| 4| 7| 7| 6| 0| 0| 4| 7| 6| 0| 7| 4| 6| 4| 2| 4| 3| 7| 6| 7| 7| DAY ON TEST | 2| 2| 5| 5| 5| 0| 2| 5| 0| 9| 5| 2| 4| 9| 2| 5| 5| 5| 6| 3| 0| 2| 9| 2| 2| | 4| 4| 4| 1| 5| 7| 4| 2| 8| 3| 6| 7| 7| 3| 7| 6| 8| 6| 9| 7| 3| 7| 9| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 480 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Liver | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X X X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 7| 0| 7| 0| 2| 7| 7| 7| 4| 7| 5| 7| 6| 7| 5| 7| 6| | | DAY ON TEST | 9| 2| 2| 2| 9| 2| 0| 8| 2| 2| 2| 5| 1| 7| 2| 1| 2| 3| 2| 8| | | | 3| 8| 8| 8| 3| 8| 8| 2| 8| 9| 9| 6| 4| 0| 9| 8| 9| 2| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | 63 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Hepatocellular Carcinoma | X | 2 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X X X X X | 10 | Hepatocellular Adenoma, Multiple | X | 4 | Lymphoma Malignant Histiocytic | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + M M + M + + + + | 67 | Lymphoma Malignant Histiocytic | | 1 | Pars Distalis, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | Follicle, Adenoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 7| 0| 7| 0| 2| 7| 7| 7| 4| 7| 5| 7| 6| 7| 5| 7| 6| | | DAY ON TEST | 9| 2| 2| 2| 9| 2| 0| 8| 2| 2| 2| 5| 1| 7| 2| 1| 2| 3| 2| 8| | | | 3| 8| 8| 8| 3| 8| 8| 2| 8| 9| 9| 6| 4| 0| 9| 8| 9| 2| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 69 | Hemangioma | | 1 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 70 | Leiomyosarcoma | X | 1 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Vagina | | 1 | Lymphoma Malignant Histiocytic | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 70 | Mediastinal, Lymphoma Malignant | | | Histiocytic | | 1 | Mediastinal, Lymphoma Malignant Mixed| | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 69 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + M + + + + + + + M + + + + | 62 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | | 1 | Lymphoma Malignant Histiocytic | | 2 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + M M + + + M + + | 62 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 64 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 69 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant Histiocytic | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 7| 0| 7| 0| 2| 7| 7| 7| 4| 7| 5| 7| 6| 7| 5| 7| 6| | | DAY ON TEST | 9| 2| 2| 2| 9| 2| 0| 8| 2| 2| 2| 5| 1| 7| 2| 1| 2| 3| 2| 8| | | | 3| 8| 8| 8| 3| 8| 8| 2| 8| 9| 9| 6| 4| 0| 9| 8| 9| 2| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | Osteosarcoma, Metastatic, Bone | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Alveolar/Bronchiolar Adenoma | X | 4 | Alveolar/Bronchiolar Carcinoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Harderian Gland | | 3 | Adenoma | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Histiocytic | | 3 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 5| 2| 5| 2| 2| 2| 2| 5| 2| 4| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| | 6| 2| 5| 2| 2| 2| 4| 6| 4| 6| 4| 4| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma, Multiple | X | Hemangiosarcoma | | Hemangiosarcoma, Multiple | X | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | + | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | Adamantinoma Benign | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 5| 2| 5| 2| 2| 2| 2| 5| 2| 4| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| | 6| 2| 5| 2| 2| 2| 4| 6| 4| 6| 4| 4| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Adenoma | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + I + + + + +| __________________________________________________________________________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +| Renal, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Nose | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + M + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M + M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 5| 2| 5| 2| 2| 2| 2| 5| 2| 4| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| | 6| 2| 5| 2| 2| 2| 4| 6| 4| 6| 4| 4| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Carcinoma, Metastatic, Nose | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 0| DAY ON TEST | 5| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 9| 9| 5| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 9| | 6| 7| 8| 4| 8| 8| 8| 8| 8| 8| 8| 3| 9| 5| 8| 8| 6| 8| 8| 8| 9| 9| 6| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma, Multiple | | Hemangiosarcoma | X | Hemangiosarcoma, Multiple | | Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | X X X X X X X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Mesentery | + + | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | Adamantinoma Benign | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 0| DAY ON TEST | 5| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 9| 9| 5| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 9| | 6| 7| 8| 4| 8| 8| 8| 8| 8| 8| 8| 3| 9| 5| 8| 8| 6| 8| 8| 8| 9| 9| 6| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Adenoma | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M M + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | M + M + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + M + + +| Carcinoma, Metastatic, Nose | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + M + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M M M M M M M M M + M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 6| 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 0| DAY ON TEST | 5| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 9| 9| 5| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 9| | 6| 7| 8| 4| 8| 8| 8| 8| 8| 8| 8| 3| 9| 5| 8| 8| 6| 8| 8| 8| 9| 9| 6| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Carcinoma, Metastatic, Nose | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 7| 7| 0| 7| 4| 0| 0| 0| 0| 7| 7| 7| 7| 0| 0| | | DAY ON TEST | 2| 5| 2| 5| 2| 2| 2| 9| 2| 5| 9| 9| 9| 9| 2| 2| 2| 2| 9| 9| | | | 9| 5| 9| 0| 9| 9| 9| 4| 9| 5| 3| 3| 3| 3| 9| 9| 1| 9| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A | 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Gallbladder | + + + + + M + + + + + + M + + + + + + + | 67 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + M + + + + + + + + + + + + + + + + | 69 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangioma, Multiple | | 1 | Hemangiosarcoma | X | 2 | Hemangiosarcoma, Multiple | | 1 | Hepatocellular Carcinoma | X X X | 7 | Hepatocellular Adenoma | X X | 8 | Hepatocellular Adenoma, Multiple | X | 13 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Mesentery | | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangioma | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Tooth | | 2 | Adamantinoma Benign | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 7| 7| 0| 7| 4| 0| 0| 0| 0| 7| 7| 7| 7| 0| 0| | | DAY ON TEST | 2| 5| 2| 5| 2| 2| 2| 9| 2| 5| 9| 9| 9| 9| 2| 2| 2| 2| 9| 9| | | | 9| 5| 9| 0| 9| 9| 9| 4| 9| 5| 3| 3| 3| 3| 9| 9| 1| 9| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A | 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 | Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 69 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 65 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + I + + + + + + + + | 64 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | Follicle, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 17 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 69 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 | Carcinoma, Metastatic, Nose | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + | 68 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 7| 7| 0| 7| 4| 0| 0| 0| 0| 7| 7| 7| 7| 0| 0| | | DAY ON TEST | 2| 5| 2| 5| 2| 2| 2| 9| 2| 5| 9| 9| 9| 9| 2| 2| 2| 2| 9| 9| | | | 9| 5| 9| 0| 9| 9| 9| 4| 9| 5| 3| 3| 3| 3| 9| 9| 1| 9| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A | 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Thymus | M + + + + + M + M + + + + + + + + M + + | 62 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M + M M M M M M M M M M M M M | 4 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Alveolar/Bronchiolar Adenoma | X X | 13 | Alveolar/Bronchiolar Carcinoma | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 1 | Carcinoma, Metastatic, Nose | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | Carcinoma | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | __________________________________________________________________________|____________| Harderian Gland | + | 3 | Adenoma | X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Undifferentiated | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 7| 7| 0| 7| 4| 0| 0| 0| 0| 7| 7| 7| 7| 0| 0| | | DAY ON TEST | 2| 5| 2| 5| 2| 2| 2| 9| 2| 5| 9| 9| 9| 9| 2| 2| 2| 2| 9| 9| | | | 9| 5| 9| 0| 9| 9| 9| 4| 9| 5| 3| 3| 3| 3| 9| 9| 1| 9| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A | 0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Cell Type | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 6| 7| 0| 6| 7| 4| 0| 6| 7| 7| 0| 0| 7| 4| 0| 7| 7| 7| 6| 7| 4| 7| 7| 7| DAY ON TEST | 5| 8| 2| 2| 5| 2| 1| 9| 7| 2| 2| 9| 9| 2| 5| 1| 2| 2| 2| 9| 2| 5| 2| 2| 2| | 6| 7| 2| 4| 0| 2| 2| 3| 7| 2| 2| 3| 3| 2| 6| 0| 2| 2| 4| 3| 4| 6| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | | __________________________________________________________________________| Mesentery | + + | Squamous Cell Carcinoma, Metastatic, | | Stomach | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + +| Follicle, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 6| 7| 0| 6| 7| 4| 0| 6| 7| 7| 0| 0| 7| 4| 0| 7| 7| 7| 6| 7| 4| 7| 7| 7| DAY ON TEST | 5| 8| 2| 2| 5| 2| 1| 9| 7| 2| 2| 9| 9| 2| 5| 1| 2| 2| 2| 9| 2| 5| 2| 2| 2| | 6| 7| 2| 4| 0| 2| 2| 3| 7| 2| 2| 3| 3| 2| 6| 0| 2| 2| 4| 3| 4| 6| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | M + M M + + + + + + M + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thymus | M + + M + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M + M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Squamous Cell Carcinoma, Metastatic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 6| 7| 0| 6| 7| 4| 0| 6| 7| 7| 0| 0| 7| 4| 0| 7| 7| 7| 6| 7| 4| 7| 7| 7| DAY ON TEST | 5| 8| 2| 2| 5| 2| 1| 9| 7| 2| 2| 9| 9| 2| 5| 1| 2| 2| 2| 9| 2| 5| 2| 2| 2| | 6| 7| 2| 4| 0| 2| 2| 3| 7| 2| 2| 3| 3| 2| 6| 0| 2| 2| 4| 3| 4| 6| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach | | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 3| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 0| 0| 0| 7| 7| 4| 4| 4| 7| 6| 7| 6| 6| DAY ON TEST | 4| 2| 2| 2| 5| 9| 2| 2| 2| 5| 2| 2| 9| 9| 9| 0| 2| 5| 6| 5| 2| 7| 2| 6| 3| | 9| 4| 4| 7| 7| 3| 7| 7| 7| 6| 7| 7| 3| 3| 3| 6| 8| 5| 4| 5| 8| 3| 8| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 120 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X | __________________________________________________________________________| Mesentery | + + + | Squamous Cell Carcinoma, Metastatic, | | Stomach | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | M + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + +| Follicle, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 3| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 0| 0| 0| 7| 7| 4| 4| 4| 7| 6| 7| 6| 6| DAY ON TEST | 4| 2| 2| 2| 5| 9| 2| 2| 2| 5| 2| 2| 9| 9| 9| 0| 2| 5| 6| 5| 2| 7| 2| 6| 3| | 9| 4| 4| 7| 7| 3| 7| 7| 7| 6| 7| 7| 3| 3| 3| 6| 8| 5| 4| 5| 8| 3| 8| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 120 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + M +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thymus | + + + M + + + M + + M M M + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Squamous Cell Carcinoma, Metastatic | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X| Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 3| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 0| 0| 0| 7| 7| 4| 4| 4| 7| 6| 7| 6| 6| DAY ON TEST | 4| 2| 2| 2| 5| 9| 2| 2| 2| 5| 2| 2| 9| 9| 9| 0| 2| 5| 6| 5| 2| 7| 2| 6| 3| | 9| 4| 4| 7| 7| 3| 7| 7| 7| 6| 7| 7| 3| 3| 3| 6| 8| 5| 4| 5| 8| 3| 8| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 120 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach | X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 7| 0| 4| 7| 7| 6| 4| 0| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 7| | | DAY ON TEST | 2| 2| 9| 5| 2| 2| 8| 5| 9| 5| 2| 5| 2| 2| 5| 9| 2| 2| 0| 2| | | | 8| 8| 3| 6| 3| 9| 2| 5| 3| 5| 9| 5| 9| 9| 2| 3| 9| 9| 7| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Gallbladder | + M + + + + + + + M + + + | 47 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + | 51 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + | 51 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + | 51 | Hepatocellular Carcinoma | X X X X X X | 11 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X X | 13 | Hepatocellular Adenoma, Multiple | X X X | 5 | __________________________________________________________________________|____________| Mesentery | + + | 7 | Squamous Cell Carcinoma, Metastatic, | | | Stomach | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + | 51 | Squamous Cell Carcinoma, Metastatic | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + | 53 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + | 53 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + | 52 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + | 52 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 52 | Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 52 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + M + + + | 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 67 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 7| 0| 4| 7| 7| 6| 4| 0| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 7| | | DAY ON TEST | 2| 2| 9| 5| 2| 2| 8| 5| 9| 5| 2| 5| 2| 2| 5| 9| 2| 2| 0| 2| | | | 8| 8| 3| 6| 3| 9| 2| 5| 3| 5| 9| 5| 9| 9| 2| 3| 9| 9| 7| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicle, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 23 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + | 50 | Squamous Cell Carcinoma, Metastatic, | | | Stomach | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + | 50 | Squamous Cell Carcinoma, Metastatic, | | | Stomach | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + | 50 | Squamous Cell Carcinoma, Metastatic, | | | Stomach | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + | 44 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Thymus | + M M + + + + + + M + + + | 38 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + | 50 | Subcutaneous Tissue, Hemangiosarcoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Squamous Cell Carcinoma, Metastatic | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 7| 7| 0| 4| 7| 7| 6| 4| 0| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 7| | | DAY ON TEST | 2| 2| 9| 5| 2| 2| 8| 5| 9| 5| 2| 5| 2| 2| 5| 9| 2| 2| 0| 2| | | | 8| 8| 3| 6| 3| 9| 2| 5| 3| 5| 9| 5| 9| 9| 2| 3| 9| 9| 7| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 120 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + | 52 | Alveolar/Bronchiolar Adenoma | X X X | 11 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | | 2 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 2 | __________________________________________________________________________|____________| Harderian Gland | + + | 4 | Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Squamous Cell Carcinoma, Metastatic, | | | Stomach | | 1 | Renal Tubule, Adenoma | | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 4| 7| 7| 7| 0| 4| 7| 7| 4| 7| 7| 0| 4| 4| 7| 7| 6| 7| 0| 7| 3| 7| 4| DAY ON TEST | 9| 2| 7| 2| 2| 2| 9| 5| 2| 2| 5| 2| 2| 9| 5| 5| 2| 2| 1| 2| 9| 2| 7| 2| 5| | 3| 2| 2| 2| 2| 2| 3| 5| 2| 2| 5| 2| 2| 3| 5| 6| 2| 4| 5| 4| 3| 4| 0| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Gallbladder | + + + + + + + + + + A + + A + | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + | Leiomyosarcoma | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + A + | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + A + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + | Hemangiosarcoma | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + A + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + | Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + | Pheochromocytoma Malignant | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + A + | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 4| 7| 7| 7| 0| 4| 7| 7| 4| 7| 7| 0| 4| 4| 7| 7| 6| 7| 0| 7| 3| 7| 4| DAY ON TEST | 9| 2| 7| 2| 2| 2| 9| 5| 2| 2| 5| 2| 2| 9| 5| 5| 2| 2| 1| 2| 9| 2| 7| 2| 5| | 3| 2| 2| 2| 2| 2| 3| 5| 2| 2| 5| 2| 2| 3| 5| 6| 2| 4| 5| 4| 3| 4| 0| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Preputial Gland | + + + +| __________________________________________________________________________| Prostate | + M + + + + + + + + + + + + + + | __________________________________________________________________________| Seminal Vesicle | + M + + + + + + + + + + + + + + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + | Hemangiosarcoma | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + M + + A + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + A + | Hemangiosarcoma | X | __________________________________________________________________________| Thymus | + M + + + M + + + + M + + + + M | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M + M M M M M | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + | Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Mediastinum, Hemangiosarcoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 4| 7| 7| 7| 0| 4| 7| 7| 4| 7| 7| 0| 4| 4| 7| 7| 6| 7| 0| 7| 3| 7| 4| DAY ON TEST | 9| 2| 7| 2| 2| 2| 9| 5| 2| 2| 5| 2| 2| 9| 5| 5| 2| 2| 1| 2| 9| 2| 7| 2| 5| | 3| 2| 2| 2| 2| 2| 3| 5| 2| 2| 5| 2| 2| 3| 5| 6| 2| 4| 5| 4| 3| 4| 0| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenocarcinoma | | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 7| 0| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 9| 2| 2| 9| 1| 2| 2| 2| 2| 5| 2| 2| 2| 5| 2| 2| 8| 2| 2| 9| 2| 2| 2| 2| 2| | 3| 4| 4| 3| 3| 4| 4| 7| 7| 5| 7| 7| 2| 6| 7| 7| 8| 7| 8| 3| 8| 8| 8| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 240 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + I + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 73 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 7| 0| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 9| 2| 2| 9| 1| 2| 2| 2| 2| 5| 2| 2| 2| 5| 2| 2| 8| 2| 2| 9| 2| 2| 2| 2| 2| | 3| 4| 4| 3| 3| 4| 4| 7| 7| 5| 7| 7| 2| 6| 7| 7| 8| 7| 8| 3| 8| 8| 8| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 240 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Thymus | + + M + + + + + + + + + M + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Mediastinum, Hemangiosarcoma | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 0| 7| 7| 0| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 9| 2| 2| 9| 1| 2| 2| 2| 2| 5| 2| 2| 2| 5| 2| 2| 8| 2| 2| 9| 2| 2| 2| 2| 2| | 3| 4| 4| 3| 3| 4| 4| 7| 7| 5| 7| 7| 2| 6| 7| 7| 8| 7| 8| 3| 8| 8| 8| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 240 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenocarcinoma | X X| Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 4| 4| 6| 4| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 5| 7| | | DAY ON TEST | 9| 9| 9| 5| 5| 0| 5| 2| 2| 2| 5| 2| 9| 2| 3| 2| 2| 2| 4| 2| | | | 3| 3| 3| 6| 6| 2| 6| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 7| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A | 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + + A + + + + + | 45 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + M + + + + + | 48 | Leiomyosarcoma | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + M + + + + + | 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + M + + + + + | 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + | 51 | Hemangiosarcoma | X | 1 | Hepatocellular Carcinoma | X X X | 9 | Hepatocellular Carcinoma, Multiple | | 2 | Hepatocellular Adenoma | X X X X X X X | 15 | Hepatocellular Adenoma, Multiple | X | 5 | __________________________________________________________________________|____________| Mesentery | + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + | 51 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + | 51 | Squamous Cell Papilloma | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + | 51 | __________________________________________________________________________|____________| Tooth | + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + | 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + | 50 | Capsule, Adenoma | X | 4 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + M + + + + + | 49 | Pheochromocytoma Malignant | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + M + + + + + | 47 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 4| 4| 6| 4| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 5| 7| | | DAY ON TEST | 9| 9| 9| 5| 5| 0| 5| 2| 2| 2| 5| 2| 9| 2| 3| 2| 2| 2| 4| 2| | | | 3| 3| 3| 6| 6| 2| 6| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 7| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A | 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Preputial Gland | + + + + | 15 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + | 49 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + | 50 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + | 47 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + M + + + + + | 44 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + | 49 | Hemangiosarcoma | | 2 | __________________________________________________________________________|____________| Thymus | + + + M M + M + + + + + + + | 41 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + | 50 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + | 50 | Alveolar/Bronchiolar Adenoma | X X X | 5 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Mediastinum, Hemangiosarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 4| 4| 6| 4| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 5| 7| | | DAY ON TEST | 9| 9| 9| 5| 5| 0| 5| 2| 2| 2| 5| 2| 9| 2| 3| 2| 2| 2| 4| 2| | | | 3| 3| 3| 6| 6| 2| 6| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 7| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A | 240 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | + + | 2 | __________________________________________________________________________|____________| Harderian Gland | + + + + | 4 | Adenoma | X X X X | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Renal Tubule, Adenocarcinoma | | 2 | Renal Tubule, Adenoma | X X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 0| 4| 0| 7| 7| 7| 7| 7| 7| 0| 4| 1| 7| 6| 0| 4| 4| 7| 0| 7| 0| 4| 7| 7| DAY ON TEST | 6| 9| 5| 9| 2| 2| 2| 2| 2| 2| 9| 5| 9| 2| 5| 9| 5| 5| 2| 0| 2| 9| 2| 0| 2| | 1| 3| 5| 3| 2| 2| 2| 2| 2| 2| 3| 5| 4| 4| 7| 3| 6| 5| 4| 9| 4| 3| 1| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hemangiosarcoma, Multiple | | Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | | __________________________________________________________________________| Mesentery | + | Hemangiosarcoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Capsule, Adenoma | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +| Adenoma | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + M + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 0| 4| 0| 7| 7| 7| 7| 7| 7| 0| 4| 1| 7| 6| 0| 4| 4| 7| 0| 7| 0| 4| 7| 7| DAY ON TEST | 6| 9| 5| 9| 2| 2| 2| 2| 2| 2| 9| 5| 9| 2| 5| 9| 5| 5| 2| 0| 2| 9| 2| 0| 2| | 1| 3| 5| 3| 2| 2| 2| 2| 2| 2| 3| 5| 4| 4| 7| 3| 6| 5| 4| 9| 4| 3| 1| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M + +| Lumbar, Hemangiosarcoma | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + A + + + + M + M + + M + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + M + + + + + + + + + M| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M M M M M M M M M M M M M M M M M + M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X| Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 4| 0| 4| 0| 7| 7| 7| 7| 7| 7| 0| 4| 1| 7| 6| 0| 4| 4| 7| 0| 7| 0| 4| 7| 7| DAY ON TEST | 6| 9| 5| 9| 2| 2| 2| 2| 2| 2| 9| 5| 9| 2| 5| 9| 5| 5| 2| 0| 2| 9| 2| 0| 2| | 1| 3| 5| 3| 2| 2| 2| 2| 2| 2| 3| 5| 4| 4| 7| 3| 6| 5| 4| 9| 4| 3| 1| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenocarcinoma | | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 81 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 4| 4| 6| 7| 6| 7| 0| 7| 7| 0| 0| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 9| 2| 2| 5| 5| 8| 0| 4| 2| 9| 2| 2| 0| 9| 5| 5| 2| 5| 2| 2| 2| 2| 2| 2| | 9| 2| 4| 4| 6| 6| 7| 6| 3| 7| 3| 7| 7| 9| 3| 5| 5| 7| 1| 7| 7| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 480 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + A + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + A + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + A + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + A + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + A + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + M A M + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hemangiosarcoma, Multiple | | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X | __________________________________________________________________________| Mesentery | + | Hemangiosarcoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Pituitary Gland | + M + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 82 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 4| 4| 6| 7| 6| 7| 0| 7| 7| 0| 0| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 9| 2| 2| 5| 5| 8| 0| 4| 2| 9| 2| 2| 0| 9| 5| 5| 2| 5| 2| 2| 2| 2| 2| 2| | 9| 2| 4| 4| 6| 6| 7| 6| 3| 7| 3| 7| 7| 9| 3| 5| 5| 7| 1| 7| 7| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 480 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + M + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M M + + + + M + + + + M + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + M + + + + + M| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X| Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| Page 83 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 4| 4| 6| 7| 6| 7| 0| 7| 7| 0| 0| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 9| 2| 2| 5| 5| 8| 0| 4| 2| 9| 2| 2| 0| 9| 5| 5| 2| 5| 2| 2| 2| 2| 2| 2| | 9| 2| 4| 4| 6| 6| 7| 6| 3| 7| 3| 7| 7| 9| 3| 5| 5| 7| 1| 7| 7| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 480 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenocarcinoma | X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 84 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 4| 6| 4| 0| 7| 7| 7| 5| 4| 3| 7| 2| 0| 7| 7| 7| 7| 7| 0| 4| | | DAY ON TEST | 6| 8| 5| 9| 2| 2| 2| 5| 5| 8| 1| 7| 9| 2| 2| 2| 2| 2| 9| 2| | | | 5| 0| 6| 3| 8| 8| 9| 8| 6| 7| 3| 5| 3| 9| 9| 9| 9| 9| 3| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + A + + + + + + + A | 65 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + A + + + + + + + + | 64 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + | 66 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + A + + + + + + + + | 63 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + + + A + + + + + + + + | 65 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | | 1 | Hemangiosarcoma, Multiple | X | 1 | Hepatocellular Carcinoma | X | 5 | Hepatocellular Adenoma | X X X X X X | 13 | Hepatocellular Adenoma, Multiple | X | 2 | __________________________________________________________________________|____________| Mesentery | + + | 4 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Squamous Cell Papilloma | X X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 69 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 69 | Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M | 67 | __________________________________________________________________________|____________| Pituitary Gland | + + + I + + + + + + + + + + + + + + + + | 65 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 4| 6| 4| 0| 7| 7| 7| 5| 4| 3| 7| 2| 0| 7| 7| 7| 7| 7| 0| 4| | | DAY ON TEST | 6| 8| 5| 9| 2| 2| 2| 5| 5| 8| 1| 7| 9| 2| 2| 2| 2| 2| 9| 2| | | | 5| 0| 6| 3| 8| 8| 9| 8| 6| 7| 3| 5| 3| 9| 9| 9| 9| 9| 3| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Penis | + | 1 | __________________________________________________________________________|____________| Preputial Gland | + | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 69 | Lumbar, Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + M M + M + + + + + + + + | 59 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Thymus | + M + + + + + I + + M + + + + + + + + M | 61 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Subcutaneous Tissue, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 86 NTP Experiment-Test: 05086-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 04/07/97 Route: GAVAGE Time: 11:09:00 __________________________________________________________________________________________________________________________________ | 4| 6| 4| 0| 7| 7| 7| 5| 4| 3| 7| 2| 0| 7| 7| 7| 7| 7| 0| 4| | | DAY ON TEST | 6| 8| 5| 9| 2| 2| 2| 5| 5| 8| 1| 7| 9| 2| 2| 2| 2| 2| 9| 2| | | | 5| 0| 6| 3| 8| 8| 9| 8| 6| 7| 3| 5| 3| 9| 9| 9| 9| 9| 3| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 480 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Alveolar/Bronchiolar Adenoma | X | 6 | Alveolar/Bronchiolar Carcinoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 3 | Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Renal Tubule, Adenocarcinoma | | 1 | Renal Tubule, Adenoma | X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 87 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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Web page last updated on November 12, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.