Vaccine Research Center (VRC)

Journal Publications, 2007

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November

European Journal of Immunology
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations.
Precopio ML, Scheinberg P, Alder NC, Roederer M, Koup RA, Douek DC, Hill AV, McShane H.
Eur J Immunol. 2007. Nov;37(11):3089.

Nature Immunology
Immunopathology of highly virulent pathogens: insights from Ebola virus.
Zampieri CA, Sullivan NJ, Nabel GJ.
Nat Immunol. 2007 Nov;8(11):1159-1164.

October

Journal of General Virology
Persistent memory CD4+ and CD8+ T-cell responses in recovered severe acute respiratory syndrome (SARS) patients to SARS coronavirus M antigen.
Yang L, Peng H, Zhu Z, Li G, Huang Z, Zhao Z, Koup RA, Bailer RT, Wu C.
J Gen Virol. 2007 Oct;88(Pt 10):2740-8.

Journal of Virology
Dendritic Cells Are Less Susceptible to HIV-2 Than HIV-1 Infection.
Duvall MG, Loré K, Blaak H, Ambrozak DA, Adams WC, Santos K, Geldmacher C, Mascola JR, McMichael AJ, Whittle HC, Rowland-Jones SL, Koup RA.
J Virol. 2007 Oct 3.

Journal of Medicinal Chemistry
Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus.
Xie H, Ng D, Savinov SN, Dey B, Kwong PD, Wyatt R, Smith AB 3rd, Hendrickson WA.
J Med Chem. 2007 Oct 4;50(20):4898-908.

Journal of Virology
Viral and host factors in human respiratory syncytial virus pathogenesis.
Collins PL, Graham BS.
J Virol. 2007 Oct 10.

Journal of Virology
Comparison of Plasma Viremia and Antibody Responses in Macaques Inoculated with Envelope Variants of Single-Cycle SIV Differing in Infectivity and Cellular Tropism.
Degottardi MQ, Lew SK, Piatak M Jr, Jia B, Feng Y, Lee SJ, Brenchley JM, Douek DC, Kodama T, Lifson JD, Evans DT.
J Virol. 2007 Oct 17.

September

American Journal of Medicine
Q fever in US military returning from Iraq.
Gleeson TD, Decker CF, Johnson MD, Hartzell JD, Mascola JR.
Am J Med. 2007 Sep;120(9):e11-2.

Nature- Medicine
Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR.
Nat Med. 2007 Sep;13(9):1032-4. Epub 2007 Aug 26.

Journal of Immunology
Acute Loss of Intestinal CD4+ T Cells Is Not Predictive of Simian Immunodeficiency Virus Virulence.
Pandrea IV, Gautam R, Ribeiro RM, Brenchley JM, Butler IF, Pattison M, Rasmussen T, Marx PA, Silvestri G, Lackner AA, Perelson AS, Douek DC, Veazey RS, Apetrei C.
J Immunol. 2007 Sep 1;179(5):3035-46.

Journal of Experimental Medicine
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.
J Exp Med. 2007 Sep 3;204(9):2171-85. Epub 2007 Aug 27.

Nature
HIV/AIDS: allied responses.
Mascola JR.
Nature. 2007 Sep 6;449(7158):29-30. No abstract available.

Journal of Immunology
Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys.
Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, Staprans SI, Sodora DL, Silvestri G.
J Immunol. 2007 Sep 1;179(5):3026-34.

Science
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.
Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J,Wilson IA, Wyatt R, Bewley CA, Kwong PD.
Science. 2007 Sep 28;317(5846):1930-4.

Journal of Immunological Methods
Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood.
van Bockel D, Price DA, Asher TE, Venturi V, Suzuki K, Warton K, Davenport MP, Cooper DA, Douek DC, Kelleher AD.
J Immunol Methods. 2007 Sep 30;326(1-2):127-38. Epub 2007 Aug 9.

August

Journal of Immunology
Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses.
Lore K, Adams WC, Havenga MJ, Precopio ML, Holterman L, Goudsmit J, Koup RA.
J Immunol. 2007 Aug 1;179(3):1721-9.

Blood
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer M, Douek DC, Morgan SH, Davis SJ, Franchini G, Koup RA.
Blood. 2007 Aug 1;110(3):928-36. Epub 2007 Apr 17.

Journal of Virology
Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut.
Wilson DP, Mattapallil JJ, Lay MD, Zhang L, Roederer M, Davenport MP.
J Virol. 2007 Aug;81(15):8025-9. Epub 2007 May 16.

Journal of Virology
No Evidence for Consistent Virus-specific Immunity in Simian Immunodeficiency Virus Exposed, Uninfected Rhesus Monkeys.
Letvin NL, Rao SS, Dang V, Buzby AP, Korioth-Schmitz B, Dombagoda D, Parvani JG, Clarke RH, Bar L, Carlson KR, Kozlowski PA, Hirsch VM, Mascola JR, Nabel GJ.
J Virol. 2007 Aug 8; [Epub ahead of print]

Journal of Immunological Methods
Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood.
van Bockel D, Price DA, Asher TE, Venturi V, Suzuki K, Warton K, Davenport MP, Cooper DA, Douek DC, Kelleher AD.
J Immunol Methods. 2007 Aug 9; [Epub ahead of print]

Science
Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity.
Yang ZY, Wei CJ, Kong WP, Wu L, Xu L, Smith DF, Nabel GJ.
Science. 2007 Aug 10;317(5839):825-8.

Nature- Medicine
Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR.
Nat Med. 2007 Aug 26; [Epub ahead of print]

Journal of Experimental - Medicine
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.
J Exp Med. 2007 Aug 27; [Epub ahead of print]

July

Blood
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
Seggewiss R, Lore K, Guenaga FJ, Pittaluga S, Mattapallil J, Chow CK, Koup RA, Camphausen K, Nason MC, Meier-Schellersheim M, Donahue RE, Blazar BR, Dunbar CE, Douek DC.
Blood. 2007 Jul 1;110(1):441-9. Epub 2007 Mar 20.

Journal of Virology
Replication competent variants of human immunodeficiency virus type-2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.
Lin G, Bertolotti-Ciarlet A, Haggarty B, Romano J, McGeehan K, Leslie G, d'Oliviere AP, Huang CC, Kwong PD, Doms RW, Hoxie JA.
J Virol. 2007 Jul 3; [Epub ahead of print]

Proceedings of the Natural Academy of Sciences
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies.
Zhu Z, Chakraborti S, He Y, Roberts A, Sheahan T, Xiao X, Hensley LE, Prabakaran P, Rockx B, Sidorov IA, Corti D, Vogel L, Feng Y, Kim JO, Wang LF, Baric R, Lanzavecchia A, Curtis KM, Nabel GJ, Subbarao K, Jiang S, Dimitrov DS.
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12123-8. Epub 2007 Jul 9.

Nature Medicine
Multifunctional T(H)1 cells define a correlate of vaccine-mediated protection against Leishmania major.
Darrah PA, Patel DT, De Luca PM, Lindsay RW, Davey DF, Flynn BJ, Hoff ST, Andersen P, Reed SG, Morris SL, Roederer M, Seder RA.
Nat Med. 2007 Jul;13(7):843-50. Epub 2007 Jun 10.

Nature Review - Microbiology
Mapping the future of HIV vaccines.
Nabel GJ
Nat Rev Microbiol. 2007 Jul; 262(1):26-43. not yet available

Journal of Virology
Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo.
Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, Trushin SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DC, Badley AD.
J Virol. 2007 Jul;81(13):6947-56. Epub 2007 Apr 18.

Journal of Internal Medicine
Inhibition of HIV-1 entry by antibodies: potential viral and cellular targets.
Phogat S, Wyatt RT, Karlsson Hedestam GB.
J Intern Med. 2007 Jul;262(1):26-43.

June

Journal of Virology
Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics, and immunogenicity.
Dey B, Pancera M, Svehla K, Shu Y, Xiang SH, Vainshtein J, Li Y, Sodroski J, Kwong PD, Mascola JR, Wyatt R.
J Virol. 2007 Jun;81(11):5579-93. Epub 2007 Mar 14.

Virology
Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection.
Rutigliano JA, Ruckwardt TJ, Martin JE, Graham BS.
Virology. 2007 Jun 5;362(2):314-9. Epub 2007 Feb 2.

Journal of Experimental Medicine
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses.
Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham BS, Roederer M, Koup RA.
J Exp Med. 2007 Jun 11;204(6):1405-1416. Epub 2007 May 29.

Journal of Immunology
Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope.
Schaubert KL, Price DA, Frahm N, Li J, Ng HL, Joseph A, Paul E, Majumder B, Ayyavoo V, Gostick E, Adams S, Marincola FM, Sewell AK, Altfeld M, Brenchley JM, Douek DC, Yang OO, Brander C, Goldstein H, Kan-Mitchell J.
J Immunol. 2007 Jun 15;178(12):7756-66.

Virology
Standardized assessment of NAb responses elicited in rhesus monkeys immunized with single- or multi-clade HIV-1 envelope immunogens.
Seaman MS, Leblanc DF, Grandpre LE, Bartman MT, Montefiori DC, Letvin NL, Mascola JR.
Virology. 2007 Jun 26; [Epub ahead of print]

May

Journal of Experimental Medicine
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses.
Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham BS, Roederer M, Koup RA.
J. Exp. Med. 2007 May 29; [Epub ahead of print]

Journal of Virology
Estimating the infectivity of CCR5-tropic SIVmac251 in the gut.
Wilson DP, Mattapallil JJ, Lay M, Zhang L, Roederer M, Davenport MP.
J Virol. 2007 May 16; [Epub ahead of print]

Blood
Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes following allogeneic stem cell transplantation for acute lymphoblastic leukemia (ALL).
Rezvani K, Yong AS, Savani BN, Mielke S, Keyvanfar K, Gostick E, Price DA, Douek DC, Barrett AJ.
Blood. 2007 May 15; [Epub ahead of print]

Vaccine
Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine.
Catanzaro AT, Roederer M, Koup RA, Bailer RT, Enama ME, Nason MC, Martin JE, Rucker S, Andrews CA, Gomez PL, Mascola JR, Nabel GJ, Graham BS; The VRC 007 Study Team.
Vaccine. 2007 May 16;25(20):4085-92. Epub 2007 Mar 7.

April

Journal of Immunological Methods
The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements.
Scheinberg P, Melenhorst JJ, Hill BJ, Keyvanfar K, Barrett AJ, Price DA, Douek DC.
J Immunol Methods. 2007 Apr 10;321(1-2):107-20. Epub 2007 Feb 2.

Journal of Acquired Immune Deficiency Syndrome
Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-seronegative subjects. Tavel JA, Martin JE, Kelly GG, Enama ME, Shen JM, Gomez PL, Andrews CA, Koup RA, Bailer RT, Stein JA, Roederer M, Nabel GJ, Graham BS.
J Acquir Immune Defic Syndr. 2007 Apr 15;44(5):601-5.

Blood
SIV-specific CD8+T-cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer M, Douek DC, Morgan SH, Davis SJ, Franchini G, Koup RA.
Blood. 2007 Apr 17; [Epub ahead of print]

Journal of Virology
HIV-1 Protease Cleaves Procaspase 8 In Vivo
Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, Trushin SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DC, Badley AD.
J Virol. 2007 Apr 18; PMID: 17442709 [PubMed - as supplied by publisher]

February

Cytometry
Differential susceptibility of leukocyte subsets to cytotoxic T cell killing: Implications for HIV immunopathogenesis.
Liu J, Roederer M.
Cytometry A. 2007 Feb;71(2):94-104.

Journal of Virology
The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity.
Zampieri CA, Fortin JF, Nolan GP, Nabel GJ.
J Virol. 2007 Feb;81(3):1230-40. Epub 2006 Nov 15.

Journal of Virology
Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2.
Kim JO, Chakrabarti BK, Guha-Niyogi A, Louder MK, Mascola JR, Ganesh L, Nabel GJ.
J Virol. 2007 Feb;81(3):1444-50. Epub 2006 Nov 8.

Cytometry Part A
Increased immunofluorescence sensitivity using 532 nm laser excitation.
Perfetto SP, Roederer M.
Cytometry A. 2007 Feb;71(2):73-9.

Journal of Acquired Immune Deficiency Syndrome
Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trial.
Russell ND, Graham BS, Keefer MC, McElrath MJ, Self SG, Weinhold KJ, Montefiori DC, Ferrari G, Horton H, Tomaras GD, Gurunathan S, Baglyos L, Frey SE, Mulligan MJ, Harro CD, Buchbinder SP, Baden LR, Blattner WA, Koblin BA, Corey L; National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network.
J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):203-12.

Virology
Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection.
Rutigliano JA, Ruckwardt TJ, Martin JE, Graham BS.
Virology. 2007 Feb 1; [Epub ahead of print]

Journal of Immunology Methods
The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements.
Scheinberg P, Melenhorst JJ, Hill BJ, Keyvanfar K, Barrett AJ, Price DA, Douek DC.
J Immunol Methods. 2007 Feb 2; [Epub ahead of print]

Vaccine
Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs.
Shu Y, Winfrey S, Yang ZY, Xu L, Rao SS, Srivastava I, Barnett SW, Nabel GJ, Mascola JR.
Vaccine. 2007 Feb 9;25(8):1398-408. Epub 2006 Nov 7.

Vaccine
Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naive and vaccinia-immune individuals.
Parrino J, McCurdy LH, Larkin BD, Gordon IJ, Rucker SE, Enama ME, Koup RA, Roederer M, Bailer RT, Moodie Z, Gu L, Yan L, Graham BS; VRC 201/203 Study Team.
Vaccine. 2007 Feb 9;25(8):1513-25. Epub 2006 Nov 7.

Nature
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD.
Nature. 2007 Feb 15;445(7129):732-7.

Journal of Experimental Medicine
Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells.
Smith AL, Ganesh L, Leung K, Jongstra-Bilen J, Jongstra J, Nabel GJ.
J Exp Med. 2007 Feb 19;204(2):421-30. Epub 2007 Feb 12.

January

Virology
Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.
Gorry PR, Dunfee RL, Mefford ME, Kunstman K, Morgan T, Moore JP, Mascola JR, Agopian K, Holm GH, Mehle A, Taylor J, Farzan M, Wang H, Ellery P, Willey SJ, Clapham PR, Wolinsky SM, Crowe SM, Gabuzda D.
Virology. 2007 Jan 17; [Epub ahead of print]

Public Library of Science Pathogens
Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys.
Oswald WB, Geisbert TW, Davis KJ, Geisbert JB, Sullivan NJ, Jahrling PB, Parren PW, Burton DR.
PLoS Pathog. 2007 Jan 19;3(1):e9 [Epub ahead of print]

Modern Pathology
The histopathology of fatal untreated human respiratory syncytial virus infection.
Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS.
Mod Pathol. 2007 Jan;20(1):108-19. Epub 2006 Nov 24.

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