Journal Publications, 2002
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December
Clinical & Experimental Immunology
Expansion of activated human naive T-cells precedes effector function.
Brenchley JM, Douek DC, Ambrozak DR, Chatterji M, Betts MR, Davis LS, Koup RA.
Clin Exp Immunol. 2002 Dec;130(3):432-40
Journal of Immunological Methods
Quantification of T-cell receptor excision circle DNA using fluorescence resonance energy transfer and the LightCycler system.
Loeffler J, Bauer R, Hebart H, Douek DC, Rauser G, Bader P, Einsele H.
J Immunol Methods. 2002 Dec 20;271(1-2):167-75.
Nature
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed S, Steenbeke TD, Venturi M, Chaiken I, Fung M, Katinger H, Parren PW, Robinson J, Van Ryk D, Wang L, Burton DR, Freire E, Wyatt R, Sodroski J, Hendrickson WA, Arthos J.
Nature. 2002 Dec 12;420(6916):678-82
November
Blood
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells.
Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA.
Blood. 2002 Nov 14
October
Journal of Infectious Diseases
Preparation of Clinical-Grade Recombinant Canarypox-Human Immunodeficiency Virus Vaccine-Loaded Human Dendritic Cells
Marovich MA, Mascola JR, Eller MA, Louder MK, Caudrelier PA, El-Habib R, Ratto-Kim S, Cox JH, Currier JR, Levine BL, June CH, Bernstein WB, Robb ML, Schuler-Thurner B, Steinman RM, Birx DL, Schlesinger-Frankel S.
J Infect Dis. 2002 Nov; 186(9):1242-52
Journal of Virology
Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein.
Xiang SH, Kwong PD, Gupta R, Rizzuto CD, Casper DJ, Wyatt R, Wang L, Hendrickson WA, Doyle ML, Sodroski J.
J Virol. 2002 Oct;76(19):9888-99
Journal of Virology
Decreased levels of recent thymic emigrants in peripheral blood of simian immunodeficiency virus-infected macaques correlate with alterations within the thymus.
Sodora DL, JM Milush, F Ware, A Wozniakowski, L Montgomery, HM McClure, AA Lackner, M Marthas, V Hirsch, RP Johnson, DC Douek, and RA Koup.
J. Virol. 76 (19): 9981-9990
September
DNA Cell Biology
Optimal antigens for HIV vaccines based on CD8+ T response, protein length, and sequence variability
Betts MR, K Yusim, and RA Koup
DNA Cell Biol. 21(9): 665-670
August
Journal of Immunology
Direct ex vivo analysis of human CD4(+) memory T cell activation requirements at the single clonotype level
Bitmansour AD, Douek DC, Maino VC, Picker LJ.
J Immunol. 169(3):1207-18
Molecular Cell
The Assembly of Ebola Virus Nucleocapsid Requires Virion-Associated Proteins 35 and 24 and Posttranslational Modification of Nucleoprotein
Yue Huang, Ling Xu, Yongnian Sun, and Gary J. Nabel
Molecular Cell. 2002;10:307-316.
Nature Immunology
Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo
Wu CY, Kirman JR, Rotte MJ, Davey DF, Perfetto SP, Rhee EG, Freidag BL, Hill BJ, Douek DC, Seder RA.
Nat Immunol. 2002 Aug 12
New England Journal of Medicine
Antiretroviral-drug resistance among patients recently infected with HIV.
Little SJ, Holte S, Routy JP, Daar ES, Markowitz M, Collier AC, Koup RA, Mellors JW, Connick E, Conway B, Kilby M, Wang L, Whitcomb JM, Hellmann NS, Richman DD.
N Engl J Med. 347(6):385-94
July
AIDS Research and Human Retroviruses
Demonstration of de novo HIV type 1 production by detection of multiply spliced and unspliced HIV type 1 RNA in paraffin-embedded tonsils.
Brachtel EF, Mascola JR, Wear DJ, Ehrenberg PK, Dayhoff DE, Sanders-Buell E, Michael NL, Frankel SS
AIDS Res and Hum Retrovirsues. 18:785-790
European Molecular Biology Organization
A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression
Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, Nabel GJ, Nabel EG.
The EMBO Journal. 21;13:3390-3401.
Journal of Dermatological Science
Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions
Foreman KE, Friborg J, Chandran B, Katano H, Sata T, Mercader M, Nabel GJ, Nickoloff BJ
J. Dermatol. Sci. 26(3):182-193
Journal of Virology
The mannose-dependent epitope for the neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120
Rogier W. Sanders, Miro Venturi, Linnea Schiffner, Roopa Kalyanaraman, Hermann Katinger, Kenneth O. Lloyd, Peter D. Kwong, John P. Moore.
J Virol. 2002 Jul;76(14):7293-305
June
Journal of Experimental Medicine
Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against leishmania major infection
Rhee EG, Mendez S, Shah JA, Wu CY, Kirman JR, Turon TN, Davey DF, Davis H, Klinman DM, Coler RN, Sacks DL, Seder RA.
J Exp Med. 2002 Jun 17;195(12):1565-73
Journal of Virology
Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization
Chakrabarti BK, Kong WP, Wu BY, Yang ZY, Friborg J, Ling X, King SR, Montefiori DC, Nabel GJ.
J Virol. 2002 Jun;76(11):5357-68.
Nature Immunology
Role of BCR affinity in T cell dependent antibody responses in vivo
Yang Shih TA, Meffre E, Roederer M, Nussenzweig MC.
Nat Immunol. 3: 570-5.
Science
HIV-1 diversity and vaccine development
Nabel G, Makgoba W, Esparza J.
Science. 2002 Jun 28;296(5577):2335
May
Journal of the American Medical Association
Hemorrhagic Fever Viruses as Biological Weapons
Borio L, Inglesby T, Peters CJ, Schmaljohn AL, Hughes JM, Jahrling PB, Ksiazek T, Johnson KM, Meyerhoff A, O'Toole T, Ascher MS, Bartlett J, Breman JG, Eitzen EM Jr, Hamburg M, Hauer J, Henderson DA, Johnson RT, Kwik G, Layton M, Lillibridge S, Nabel GJ, Osterholm MT, Perl TM, Russell P, Tonat K; The Working Group on Civilian Biodefense.
JAMA. 2002 287;(18):2391-405.
Journal of Virology
Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cells
Mascola JR, Louder MK, Winter C, Prabhakara R, De Rosa SC, Douek DC, Hill BJ, Gabuzda D, Roederer M.
J Virol. 2002;76:4810-21
Journal of Virology
Highly Stable Trimers Formed by Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Fused with the Trimeric Motif of T4 Bacteriophage Fibritin
Xinzhen Yang, Juliette Lee, Erin M. Mahony, Peter D. Kwong, Richard Wyatt, and Joseph Sodroski
J. Virol. 2002 76: 4634-4642.
Journal of Virology
NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus
Johnson TR, Hong S, Van Kaer L, Altman JD, Koezuka Y, Graham BS.
Journal of Virology. 2002; 76:4294-4303.
Nature
HIV preferentially infects HIV-specific CD4+ T cells
Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA.
Nature. 2002 May 2;417(6884):95-8
Vaccine
HIV vaccine strategies
Nabel GJ.
Vaccine. 2002 May 6;20(15):1945-7.
Vaccine
Passive Transfer Studies to Elucidate the Role of Antibody-mediated Protection Against HIV-1
Mascola JR.
Vaccine. 2002;20:1922-25
April
American Journal of Respiratory and Critical Care Medicine (Non-government)
Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice
Peebles RS, Hashimoto K, Morrow JD, Dworski R, Collins RD, Jarzecka K, Mitchell DB, Graham BS, Sheller JR. American Journal of Respiratory and Critical Care Medicine 2002; 165:1154-1160.
Accompanying editorial: Peters-Golden M. Open mind, open airways: Broadening the paradigm of prostaglandins and allergic airway inflammation. AJRCCM 2002; 165:1035-1036.
AIDS
Immune reconstitution in HIV-1-infected children on antiretroviral therapy: role of thymic output and viral fitness
Ometto L, De Forni D, Patiri F, Trouplin V, Mammano F, Giacomet V, Giaquinto C, Douek D, Koup R, De Rossi A.
AIDS. 2002 Apr 12;16(6):839-49
Blood
Effects of exogenous interleukin-7 on human thymus function
Okamoto Y, Douek DC, McFarland RD, Koup RA.
Blood. 2002 Apr 15;99(8):2851-8
Journal of Infectious Diseases
Illness severity, virus shedding, and antibody responses in patients hospitalized with bronchiolitis caused by respiratory syncytial virus - (Non-government PDF).
Wright PF, Gruber WC, Peters M, Reed G, Zhu YW, Robinson F, Coleman-Dockery S, Graham BS.
Journal of Infectious Diseases. 2002; 185:1011-1018.
Journal of Virology
Solid-phase proteoliposomes containing human immunodeficiency virus envelope glycoproteins.
Grundner C, Mirzabekov T, Sodroski J, Wyatt R.
J Virol. 2002 Apr;76(7):3511-21
Nature Immunology
Role of antigen receptor affinity in T cell-independent antibody responses in vivo
Shih TA, Roederer M, Nussenzweig MC
Nat Immunol. 3: 399-406.
March
Cancer Research
Cellular localization and function of Fas ligand (CD95L) in tumors
Kurooka M, Nuovo GJ, Caligiuri MA, Nabel GJ.
Cancer Res. 2002 Mar 1;62(5):1261-5.
Journal of Clinical Investigation
Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis
Karandikar NJ, Crawford MP, Yan X, Ratts RB, Brenchley JM, Ambrozak DR, Lovett-Racke AE, Frohman EM, Stastny P, Douek DC, Koup RA, Racke MK.
J Clin Invest. 2002 Mar;109(5):641-9
Journal of Acquired Immune Deficiency Syndrome
Safety and immunogenicity of a high-titered canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS Vaccine Evaluation Group Protocol 022A
Gupta K, Hudgens M, Corey L, McElrath MJ, Weinhold K, Montefiori DC, Gorse GJ, Frey SE, Keefer MC, Evans TG, Dolin R, Schwartz DH, Harro C, Graham B, Spearman PW, Mulligan M, Goepfert P.
Journal of Acquired Immune Deficiency Syndrome. 2002; 29:254-261.
Journal of Immunology
A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape
Douek DC, Betts MR, Brenchley JM, Hill BJ, Ambrozak DR, Ngai KL, Karandikar NJ, Casazza JP, Koup RA.
J Immunol. 2002 Mar 15;168(6):3099-104
Journal of Immunology
The role of interferon in RSV pathogenesis
Durbin J, Johnson TR, Durbin RK, Mertz S, Peebles RS, Jr., Graham BS.
Journal of Immunology. 2002; 168:2944-2951.
February
Blood
A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation.
Talvensaari K, Clave E, Douay C, Rabian C, Garderet L, Busson M, Garnier F, Douek D, Gluckman E, Charron D, Toubert A.
Blood. 99(4):1458-64
Journal of Immunology
CpG oligodeoxynucleotides as vaccine adjuvants in primates
Verthelyi D, Kenney RT, Seder RA, Gam AA, Friedag B, Klinman DM.
J Immunol. 2002 Feb 15;168(4):1659-63
Virology
Respiratory Syncytial Virus Immunobiology and Pathogenesis - (PDF).
Graham BS, Rutigliano JA, Johnson TR.
Virology. 2002.
January
Journal of Virology
Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice
Moore AC, Kong WP, Chakrabarti BK, Nabel GJ.
J Virol. 2002 Jan;76(1):243-50
Thorax (Non-government)
Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor (PDF)
Hashimoto K, Peebles RS, Sheller JR, Jarzecka K, Furlong J, Mitchell DB, Graham BS.
Thorax. 2002; (in press).
2002 Annual Review (Non-government)
Advances in Experimental Biology and Medicine (Non-government)-2002
IL-7, the thymus and naïve T cells
Okamoto Y, Douek DC, McFarland RD, Koup RA
Adv Exp Med Biol. 512:81-90
Annual Review of Medicine (Non-government)
Clinical Trials of HIV Vaccines
Graham BS.
Annual Review of Medicine. 2002; 53:207-221.
Current Protocols in Immunology
Multiparameter FACS Analysis
Roederer, M., Coligan, J. E., Margulies, D. H., Shevach, E. M., Strober, W., Coico, R. and Kruisbeek, A. (ed.),
John Wiley & Sons, Inc. New York, (in press).
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