The Breast Cancer Think Tank (BCTT) has monies available in fiscal year 2002 to fund projects and programs the Breast Cancer Think Tank community decides are important to its goals. The BCTT Steering Committee is, once again, soliciting proposals to support these initiatives. As an encouragement to work cohesively between departments, collective proposals will be given additional consideration. Proposals should provide a broad level of support to the NIH community involved in breast cancer research. Because of the need for multi-year resources, this mechanism should not be used for requests to fund post-doctoral fellows. Please also note that these awards can only be awarded to intramural investigators. Projects that involve collaborations with the extramural community are appropriate, but the awards must be made to a member of the intramural community. Please note that these awards will be allocated in FY2002. Therefore the DEADLINE for SUBMISSION is Wednesday, August 1, 2001. Recipients will be notified when the fiscal year 2002 budget is approved.

1. Building the infrastructure of the BCTT community e.g., establishment of a resource database; symposia, workshops, or didactic programs.
2. Funding of service work for projects that will benefit a significant fraction of the community, e.g., Sequencing costs involved in the gene discovery phase of MGAP (Mammary Genome Anatomy Project) production of new animal models or maintaining a colony of animals.
3. Purchase of "core" equipment needed as a shared resource by the community.
4. Funding new innovative individual projects are categorized as "high-risk" or "high-impact."
5. Funding for translational research on clinical specimens, for example: “EGFR phosphorylation in tumor tissue; assay development or scale-up for novel biomarkers linked to breast cancer risk or etiologic studies testing novel hypotheses using existing biologic specimen resources”.

1. Title

2. Designate whether the application is categorized scientific or infrastructure.

3. Indicate whether previous funding from the BCTT has been received and, if yes, provide a one-page summary, on a separate page, of the progress of such funding.

4. Indicate whether you have requested funding from another mechanism within the National Cancer Institute and, if yes, provide an explanation as to whom you have requested such funding and the amount.

5. Description of project/technology/equipment (no more than two pages.)

6. Relevance to mission of Breast Cancer Think Tank.

7. If shared resources, please include a statement as to how investigators will obtain access to its use.

8. Budget

9. Collaborative investigators with brief biosketches (NO cvs, please)

10. Name, address, phone, fax, and e-mail of primary investigator responsible for communicating about the grant.

• Scientific merit: Applications categorized scientific will be reviewed and scored by members of the scientific community. Steering Committee members may participate in this review process provided they have not submitted a grant in the scientific category. Scientific review from members outside the Steering Committee will be solicited as needed according to their area of expertise.

• Infrastructure: Value to thebroad community as determined by the Steering Committee.

• Sustainable program

• Meets BCTT priority criteria

• Ability of investigators to complete the project