Summaries & Associations of Study Results
TR-306 Methylene Chloride
Target Organs and Levels of Evidence
NTP Technical Report Number 306
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| METHYLENE CHLORIDE 75-09-2 |
03/29/85 | SOLVENT IN PAINT REMOVERS, DEGREASERS, AEROSOL PROPELLANTS, EXTRACTION SOLVENT IN FOOD PROCESSING; PHARMACEUTICAL AID, COMPONENT OF FIRE EXTINGUISHING CMPD (HSDB 1990) | Inhalation R: 0,1000,2000,4000, M: 0,2000,4000 PPM/50 PER GROUP | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | MAMMARY GLAND: ADENOMA 0/50 0/50 0/50 1/50 OR FIBROADENOMA 0/50 0/50 2/50 4/50 COMBINED 0/50 0/50 2/50 5/50 | |||
| FR: CLEAR EVIDENCE | MAMMARY GLAND: ADENOMA 0/50 0/50 0/50 1/50 OR FIBROADENOMA 5/50 11/50 13/50 22/50 COMBINED 5/50 11/50 13/50 23/50 | |||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 10/50 14/49 14/49 OR CARCINOMA 13/50 15/49 26/49 COMBINED 22/50 24/49 33/49 | |||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 19/50 24/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 10/50 28/50 | ||||
| FM: CLEAR EVIDENCE | LIVER: ADENOMA 2/50 6/48 22/48 OR CARCINOMA 1/50 11/48 32/48 COMBINED 3/50 16/48 40/48 | |||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 23/48 28/48; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 13/48 29/48 | ||||
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