Other challenges apply specifically to the use of nanostructures within biological systems. Nanostructures can be so small that the body may clear them too rapidly for them to be effective in detection or imaging. Larger nanoparticles may accumulate in vital organs, creating a toxicity problem. Scientists will need to consider these factors as they attempt to create nanodevices the body will accept.
![Designing Nanodevices for Use in the Body](https://webarchive.library.unt.edu/eot2008/20090201161740im_/http://newscenter.cancer.gov/images/Documents/59f950a6-9b9d-43ad-80a4-776cefdd17ce/cancer4.jpg)
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