Diabetes: Prevention - Slide 6

Note:

The clinical trial ended one year earlier than planned because the results were so clear:

• The lifestyle intervention group reduced their risk of developing diabetes by 58 percent.

• This powerful reduction in risk of diabetes was found in all subgroups, including men and women, the ethnic groups that made up 45 percent of participants, women with a history of gestational diabetes, and people age 60 and older.

• In fact, lifestyle changes worked particularly well for participants aged 60 and older—who as a group have nearly 20 percent prevalence of diabetes—reduced their risk of developing diabetes by 71 percent.

• Participants who took metformin reduced their risk of developing diabetes by 31 percent.

• Metformin was effective for both men and women, and was more effective in younger, heavier people—those 25 to 40 years old with a BMI of 36 (about 50 to 80 pounds overweight).

Reference

Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002, Vol.346, No. 6.

Revised September 2008