Diabetes: Prevention - Slide 4

DPP Methods

• Lifestyle intervention

  • 5% to 7% weight reduction
  • Healthy low-calorie, low-fat diet

  • 30 minutes of physical activity, 5 days a week

• Metformin

  • Oral diabetes drug

• Placebo

DPP Research Group. N Engl J Med 2002, Vol.346, No. 6.

Note:

Diabetes Prevention Program (DPP) participants were randomly assigned to one of three interventions:

1. The intensive lifestyle modification program, where participants were encouraged to lose 5% to 7% of their bodyweight by following a healthy low-calorie, low-fat diet and by getting 30 minutes of physical activity, 5 days a week.

2. Standard lifestyle recommendations plus metformin, an oral diabetes drug.

3. Standard lifestyle recommendations plus placebo twice daily.

Reference

Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002, Vol.346, No. 6.

Revised September 2008