Summaries & Associations of Study Results
TR-291 Isophorone
Target Organs and Levels of Evidence
NTP Technical Report Number 291
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| ISOPHORONE 78-59-1 |
11/02/84 | SOLVENT. CHEMICAL INTERMEDIATE. (TDB) | Gavage 0,250,500 MG/KG/50 PER GROUP | Papanicolaou Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 3/50 1/50 | |||
| PREPUTIAL GLAND: CARCINOMA 0/50 0/50 5/50 | ||||
| FR: NO EVIDENCE | ||||
| MM: EQUIVOCAL EVIDENCE | LIVER: ADENOMA 6/48 7/50 13/50 OR CARCINOMA 14/48 13/50 22/50 COMBINED 18/48 18/50 29/50 | |||
| SUBCUTANEOUS TISSUE: FIBROMA 0/48 2/50 3/50; FIBROSARCOMA 3/48 4/50 10/50; NEUROFIBROSARCOMA 1/48 0/50 0/50; SARCOMA 0/48 0/50 1/50 | ||||
| HEMATOPOIETIC SYSTEM: LYMPHOMA 8/48 18/50 5/50 | ||||
| FM: NO EVIDENCE | ||||
Web page last updated on February 10, 2006
