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AGENDA |
Organizers: Ronald Evans, Saul Karpen, Joel Lavine, Ronald Margolis, Edward Doo, and Patricia Robuck
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Day 1—Wednesday, November 7, 2007 |
8:00 a.m. – 8:15 a.m. |
Welcome Griffin Rodgers, Director, NIDDK
Workshop Goals
Ronald Margolis, NIDDK |
8:15 a.m. – 8:45 a.m. |
Nuclear Receptors: Overview
Ronald Evans, The Salk Institute for Biological Studies |
8:45 a.m. – 10:05 a.m. |
Session 1: Basic Biology of Nuclear Receptor Action
Moderator: Bert O’Malley, Baylor College of Medicine |
8:45 a.m. |
Nuclear Receptors as Lipid Receptors
David Mangelsdorf, The University of Texas (UT) Southwestern Medical Center
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9:05 a.m. |
Nuclear Co-Regulator Mechanisms in Disease
Bert O’Malley, Baylor College of Medicine
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9:25 a.m. |
The Nuclear Receptor Signaling Atlas (NURSA)
Ronald Margolis, NIDDK
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9:45 a.m. |
Discussion |
10:05 a.m. – 10:25 a.m. |
Break |
10:25 a.m. – 11:45 a.m. |
Session 2: Nuclear Receptor Physiology
Moderator: David Mangelsdorf, UT Southwestern Medical Center |
10:25 a.m. |
Nuclear Receptors and Fibroblast Growth Factors in the Liver
Steve Kliewer, UT Southwestern Medical Center |
10:45 a.m. |
Nuclear Receptor Regulation of Drug Disposition Chris Liddle, The University of Sydney, Westmead Hospital |
11:05 a.m. |
Bile Acid Signaling From Nuclear Receptors to G-Protein Coupled Receptors
Johan Auwerx, Institut de Génétique et de Biologie Moléculaire et Cellulaire and
Institut Clinique de la Souris, Strasbourg, France
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11:25 a.m. |
Discussion |
11:45 a.m. – 1:00 p.m. |
Lunch (on your own) |
1:00 p.m. – 2:20 p.m. |
Session 3: Integration of Nuclear Receptors and Homeostasis
Moderator: Chris Glass, University of California (UC) at San Diego
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1:00 p.m. |
Nuclear Receptors and the Metabolic Syndrome
Mitch Lazar, University of Pennsylvania
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1:20 p.m. |
Nuclear Receptors, Inflammation, and Metabolic Disease
Chris Glass, UC at San Diego |
1:40 p.m. |
Metabolic Control Through the PGC-1/SIRT1 Transcriptional Complex Activity
Pere Puigserver, Dana Farber Cancer Institute
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2:00 p.m. |
Discussion |
2:20 p.m. – 2:40 p.m. |
Break |
2:40 p.m. – 3:10 p.m. |
Clinical/Translational Challenges: Overview
Saul Karpen, Baylor College of Medicine |
3:10 p.m. – 4:50 p.m. |
Session 4: Hepatic Pathophysiology of Nuclear Receptors
Moderator: Michael Trauner, Medical University of Graz |
3:10 p.m. |
Molecular Regulation of Hepatic Fibrosis and the Role of Nuclear Receptors
Scott Friedman, Mount Sinai School of Medicine |
3:30 p.m. |
Nuclear Receptors and Hepatotoxicity
Wan Xie, University of Pittsburgh Medical College |
3:50 p.m. |
Cholestasis
Michael Trauner, Medical University of Graz |
4:10 p.m. |
Late-Breaking
Story: Identification of Heme as the Ligand for the Orphan Nuclear Receptors
Rev-Erbα and Rev-Erbβ
Thomas Burris, Pennington Biomedical Research Center |
4:30 p.m. |
Discussion |
5:00 p.m. – 7:00 p.m. |
Poster Session |
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Day 2—Thursday, November 8, 2007 |
8:00 a.m. – 9:40 a.m. |
Session 5: Disease States and Nuclear Receptors
Moderator: Joel Lavine, UC at San Diego |
8:00 a.m. |
Isolated Genetic Defects in Nuclear Receptors
Krishna Chatterjee, Cambridge University |
8:20 a.m. |
Nuclear Receptors and Inflammatory Bowel Disease
Frank Gonzalez, National Cancer Institute |
8:40 a.m. |
Non-Alcoholic Steatohepatitis
Joel Lavine, UC at San Diego |
9:00 a.m. |
Gallstones
Alan Hofmann, UC at San Diego |
9:20 a.m. |
Discussion |
9:40 a.m. – 10:00 a.m. |
Break |
10:00 a.m. – 10:45 a.m. |
Session 6: Late-Breaking Stories
Moderator: Ronald Margolis, NIDDK |
10:00 a.m. |
Decreased Histone H3K9 Acetylation at Bile Acid Transporter Gene Promoters
During Rat Liver Development and Obstructive Cholestasis
Meena Ananthanarayanan, Mount Sinai Medical Center |
10:15 a.m. |
Farnesoid X Receptor, the Bile Acid Activated Nuclear Receptor, Attenuates
Colon Cancer Development in Mice
Grace Guo, University of Kansas Medical Center |
10:30 a.m. |
A Randomized,
Placebo-controlled Trial of the PPARγ Ligand
Rosiglitazone for Active Ulcerative Colitis
Gary Wu, University of Pennsylvania |
10:45 a.m. – 12:45 p.m. |
Session 7: Translation
Moderator: Erin Schuetz, St. Jude’s Hospital for Children |
10:45 a.m. |
Pharmacogenomics
Erin Schuetz, St. Jude’s Hospital for Children |
11:05 a.m. |
The Design and Development of PPARdelta Ligands for the Treatment of
Metabolic Syndrome
Rich Heyman, Kalypsys, Inc. |
11:25 a.m. |
Diabetes, Drug Metabolism, and Vice Versa
David Moore, Baylor College of Medicine |
11:55 a.m. |
Nuclear Receptors and NASH: Bench to Bedside
Anna Mae Diehl, Duke University |
12:15 p.m. |
Discussion |
12:45 p.m. – 1:00 p.m. |
Open Discussion: Meeting Summary and Future Directions
Panel: Meeting Organizers
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1:00 p.m. |
Adjourn |
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