Summaries & Associations of Study Results
TR-461 Nitromethane
Target Organs and Levels of Evidence
NTP Technical Report Number 461
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| NITROMETHANE 75-52-5 |
12/05/95 | FUEL ADDITIVE AND PROPELLANT. CELLULOSIC COMPOUND SOLVENT. INTERMEDIATE FOR NITRO AND AMINO ALCOHOLS. (TDB) | Inhalation R: 0, 94, 188, OR 375 PPM; 50/GROUP M: 0, 188, 375, OR 750 PPM; 50/GROUP | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| FR: CLEAR EVIDENCE | MAMMARY GLAND: FIBROADENOMA 19/50 21/50 33/50 36/50 OR CARCINOMA 2/50 7/50 1/50 11/50 COMBINED 9/50 25/50 34/50 39/50 | |||
| MM: CLEAR EVIDENCE | HARDERIAN GLAND: ADENOMA 9/50 10/50 19/50 32/50 OR CARCINOMA 1/50 1/50 6/50 5/50 COMBINED 10/50 11/50 25/50 37/50 | |||
| LUNG: ALVEOLAR ADENOMA 11/50 10/50 9/50 12/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 3/50 3/50 11/50 COMBINED 13/50 13/50 12/50 20/50 | ||||
| NON-NEOPLASTIC LESIONS: | NOSE: OLFACTORY EPITHELIUM, DEGENERATION; OLFACTORY EPITHELIUM, METAPLASIA; RESPIRATORY EPITHELIUM, HYALINE DEGENERATION | |||
| FM: CLEAR EVIDENCE | HARDERIAN GLAND: ADENOMA 5/50 7/50 16/50 19/50 OR CARCINOMA 1/50 2/50 4/50 3/50 COMBINED 6/50 9/50 20/50 21/50 | |||
| LIVER: ADENOMA 14/50 25/50 17/50 35/50 OR CARCINOMA 10/50 14/50 8/50 12/50 COMBINED 19/50 34/50 22/50 40/50 | ||||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/50 2/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/50 5/50 3/50 COMBINED 3/50 6/50 6/50 12/50 | ||||
| NON-NEOPLASTIC LESIONS: | NOSE: OLFACTORY EPITHELIUM, DEGENERATION; OLFACTORY EPITHELIUM, METAPLASIA; RESPIRATORY EPITHELIUM, HYALINE DEGENERATION | |||
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