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Brain’s Wiring Stunted, Lopsided in Childhood Onset Schizophrenia
October 30, 2008 • Science Update
Growth of the brain’s long distance connections, called white matter, is stunted and lopsided in children who develop psychosis before puberty, NIMH researchers have discovered.
Task Force Finds Cognitive Behavioral Therapy Effective for Children and Adolescents Exposed to Trauma
October 29, 2008 • Science Update
Individual and group cognitive behavioral therapy (CBT) were the only interventions found effective in an evaluation of seven commonly-used approaches to reduce the psychological harm to youth who experience trauma.
Symptoms Persist as Bipolar Children Grow Up
October 27, 2008 • Science Update
Bipolar disorder (BD) identified in childhood often persisted into adulthood in the first large follow-up study of its kind. Forty-four percent of children diagnosed with BD continued to have manic episodes as adults, in the study by NIMH grantee Barbara Geller, M.D.
Lack of Eye Contact May Predict Level of Social Disability in Two-Year Olds with Autism
October 23, 2008 • Science Update
By age 2, children with autism show unusual patterns of eye contact compared with typically developing children. This symptom appears to be related to a child's level of impairment and may be a useful biomarker for diagnosing autism at an earlier age.
Social Phobia Patients Have Heightened Reactions to Negative Comments
October 22, 2008 • Science Update
In a study using functional brain imaging, NIMH scientists found that when people with generalized social phobia were presented with a variety of verbal comments about themselves and others (“you are ugly,” or “he’s a genius,” for example) they had heightened brain responses only to negative comments about themselves.
Certain Antipsychotic Medications May Increase Risk for Heart Disease
October 16, 2008 • Science Update
Certain atypical antipsychotic medications may raise the risk for heart disease in people with schizophrenia.
Pilot Study Will Test New Treatment to Reduce Self-Harm in Borderline Personality Disorder
October 9, 2008 • Science Update
NIMH recently funded Kim Gratz, Ph.D., University of Mississippi Medical Center, and colleagues to continue to test a new group therapy to help women with borderline personality disorder reduce self-harm behaviors and to improve functioning.
Viral Genetic Underpinnings of HIV-associated Dementia Explored
October 9, 2008 • Science Update
A new study identifies differences between genetic variants of HIV that are associated with HIV-associated dementia (HAD).
Emotion-Regulating Circuit Weakened in Borderline Personality Disorder
October 2, 2008 • Science Update
Differences in the working tissue of the brain, called grey matter, have been linked to impaired functioning of an emotion-regulating circuit in patients with borderline personality disorder (BPD). People with BPD had excess grey matter in a fear hub deep in the brain, which over-activated when they viewed scary faces. By contrast, the hub’s regulator near the front of the brain was deficient in grey matter and underactive, effectively taking the brakes off a runaway fear response, suggest researchers supported in part by NIMH.
Millisecond Brain Signals Predict Response to Fast-Acting Antidepressant
October 2, 2008 • Press Release
Images of the brain’s fastest signals reveal an electromagnetic marker that predicts a patient’s response to a fast-acting antidepressant, researchers have discovered.
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