Summaries & Associations of Study Results
TR-386 Tetranitromethane
Target Organs and Levels of Evidence
NTP Technical Report Number 386
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TETRANITROMETHANE 509-14-8 |
11/20/89 | ROCKET PROPELLANTS; ADDITIVE TO DIESEL FUEL; EXPLOSIVE; REAGENT | Inhalation R: 0,2,5, M: 0,0.5,2 PPM/50 PER GROUP | Midwest Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 13/50 11/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 19/50, COMBINED 0/50 26/50 46/50; SQUAMOUS CELL CARCINOMA 1/50 1/50 19/50; SARCOMA 0/50 0/50 1/50 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC; RESPIRATORY EPITHELIUM, HYPERPLASIA, SQUAMOUS METAPLASIA LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA | |||
| FR: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 6/50 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 19/50 50/50 COMBINED 0/50 22/50 50/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 12/50; MALIGNANT MIXED TUMORS 0/50 0/50 1/50; SARCOMA 0/50 0/50 1/50 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC; RESPIRATORY EPITHELIUM, HYPERPLASIA LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA | |||
| MM: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 17/50 34/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 16/50 46/50 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA | |||
| FM: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 19/50 41/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 11/50 45/50 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA | |||
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