Summaries & Associations of Study Results
TR-366 Hydroquinone
Target Organs and Levels of Evidence
NTP Technical Report Number 366
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| HYDROQUINONE 123-31-9 |
10/03/88 | PHOTOGRAPHIC DEVELOPER. INTERMED. IN MANUFAC. OF DYES, RUBBER ANTIOXIDANTS. POLYMERIZATION INHIBITOR. STABILIZER. REAGENT. MEDICINE FOR SKIN BLEMISHES. (TDB) IN SKIN-LIGHTENING CREAMS (MEDLINE) FOUND IN COAL TAR EFFLUENT | Gavage R: 0,25,50, M: 0,50,100 MG/KG/65 PER GROUP | American Biogenics Corp (Bioassay Systems) |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 0/55 4/55 8/55 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: ANISOKARYOSIS 0/55 2/54 12/55; BASOPHILIC FOCUS 2/55 5/54 11/55 | |||
| FR: SOME EVIDENCE | HEMATOPOIETIC SYSTEM: LEUKEMIA 9/55 15/55 22/55 | |||
| MM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICULAR CELL, HYPERPLASIA 9/55 15/53 19/54 | |||
| LIVER: ANISOKARYOSIS 0/55 2/54 12/55; BASOPHILIC FOCUS 2/55 5/54 11/55; SYNCYTIAL ALTERATION 5/55 3/54 25/55 | ||||
| FM: SOME EVIDENCE | LIVER: ADENOMA 2/55 15/55 12/55 OR CARCINOMA 1/55 1/55 1/55 COMBINED 3/55 16/55 13/55 | |||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICULAR CELL, HYPERPLASIA 13/55 47/55 45/55 | |||
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