Following the characterization and peer-reviewed publication
of the transgenic mouse strain generated, mice will be freely distributed
to investigators at academic institutions wanting mice for non-commercial
research. Individual requests for shipment of mice generated by
this program project funding to AAALAC (Association for Assessment
and Accreditation of Laboratory Animal Care International) accredited
institutions will be honored. The recipient investigators would
provide written assurance and evidence that the animals will be
used solely in accord with their local IACAC review; that animals
will not be further distributed by the recipient without consent
of our-Program; that animals will not be used for commercial
purposes.
Requests for mice from for-profit corporations to use the mice
commercially will be negotiated by our institution's technology
transfer office. All licensing shall be subject to distribution
pursuant to my institution's policies and procedures on royalty
income. The technology transfer office will report any invention
disclosure submitted to them to the appropriate Federal Agency.
In addition, all of the transgenic mice generated will be deposited
in at an NIH supported mouse repository [see Section IV for part
list of mouse repositories and database. NIH supported repositories
cryopreserve embryos or sperm and distribute the frozen embryos
or mice to biomedical researchers. For the mice I generate I will
use standard nomenclature and receive approval from the Mouse Genome
Informatic (MGI) nomenclature committee http://www.informatics.jax.org/.
To facilitate sharing and distribution of the transgenic/knockout
mice and associated resources developed under this grant, mice
will be maintained in a specific pathogen free facility. This facility
will maintain the mice free of the following micro-organisms and
pathogens (e.g., pinworms, mouse hepatitis virus (MHV), Sendai
virus, mycoplasma, mites, etc.) Should the transgenic/knockout
mice become infected with any of these micro-organisms, the mice
will be rederived through embryo transfer.
"Other Research Resources" generated with funds from
this grant will include DNA constructs, etc. These resources, as
available, would also be freely distributed upon request to qualified
academic investigators for non-commercial research.
My institution and I will adhere to the NIH Grants Policy on Sharing
of Unique Research Resources including the "Sharing of Biomedical
Research Resources: Principles and Guidelines for Recipients of
NIH Grants and Contracts" issued in December, 1999 http://ott.od.nih.gov/policy/rt_guide_final.html.
Specifically, material transfers would be made with no more restrictive
terms than in the Simple Letter Agreement or the UBMTA and without
reach through requirements. Should any intellectual property arise
which requires a patent, we would ensure that the technology remains
widely available to the research community in accordance with the
NIH Principles and Guidelines document.
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