Summaries & Associations of Study Results
Levels from TR-538 Methyl Isobutyl Ketone
Target Organs and Levels of Evidence
NTP Technical Report Number 538
Produced from Chemtrack Database 02/07/06
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| METHYL ISOBUTYL KETONE 108-10-1 |
09/27/05 | MIBK IS PRODUCED AT APPROX 200 MILLION LBS/YR AND IS USED AS A CHEMICAL INTERMED; AS A SOLVENT FOR PAINTS, VARNISHES AND NITROCELLULOSE; IN DRY CLEANING PREPARATIONS; AND AS A SYNTHETIC FLAVOR ADJUVANT. MIBK ALSO HAS A HIGH ENVIRONMENTAL RELEASE (27.7 MILLION LBS.YR, WITH >98% GOING INTO THE AIR) AN | Inhalation R&M: 0, 450, 900, OR 1800 PPM | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA (STANDARD EVALUATION - 0/50 0/50 2/50 3/50; STANDARD AND EXTENDED EVAULATION COMBINED - 2/50 3/50 3/50 10/50); CARCINOMA (STANDARD EVALUATION - 0/50 1/50 0/50 2/50); ADENOMA OR CARCINOMA (COMBINED) (STANDARD EVAULATION - 0/50 1/50 2/50 4/50; STANDARD AND EXTENDED EVALUATION - 2/50 4/50 3/50 11/50) | |||
| MAY HAVE BEEN RELATED: | MONONUCLEAR CELL LEUKEMIA: 25/50 26/50 32/50 35/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: TUBULE HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY; PELVIS TRANSITIONAL EPITHELIAL HYPERPLASIA; PAPILLA MINERALIZATION | |||
| ADRENAL GLAND: ADRENAL MEDULLA HYPERPLASIA | ||||
| FR: EQUIVOCAL EVIDENCE | KIDNEY MESENCHYMAL CELL: TUMOR MALIGNANT 0/50 0/50 0/50 2/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: NEPHROPATHY | |||
| MM: SOME EVIDENCE | LIVER: ADENOMA 17/50 25/50 23/50 34/50 ADENOMA OR CARCINOMA (COMBINED) 27/50 34/50 28/50 37/50 | |||
| FM: SOME EVIDENCE | LIVER: ADENOMA 13/50 15/50 20/50 23/50 ADENOMA OR CARCINOMA (COMBINED) 17/50 17/50 22/50 27/50 | |||
Web page last updated on February 10, 2006
