National Toxicology Program

                                 September, 1994
                           
      
THE NTP LIAISON OFFICE IS PLEASED TO PROVIDE THE FOLLOWING:

We are pleased to provide the following information from the National Toxicology Program. 
Inquiries and comments regarding the NTP are welcome and encouraged. 
     CONTACT: Ms. Sandra Lange, Director NTP Liaison Office 
              Phone 919-541-0530 FAX 919-541-0295  
              (address shown above)

               ###############

--  NTP Workshop on Mechanism-Based Toxicology in 
    Cancer Risk Assessment: Implications for Research, 
    Regulation, and Legislation; 
    January 11-13, 1995, Chapel Hill, NC. 
    ANNOUNCEMENT & REGISTRATION INFORMATION ATTACHED 
    CONTACT: NTP Liaison Office (address shown above)

--  NTP Board of Scientific Counselors Meeting, 
    October 18, 1994, National Institute of Environmental 
    Health Sciences Main Conference Facility, 
    111 Alexander Drive, Research Triangle Park, NC 27709. 
    CONTACT: Dr. Larry Hart 
             NTP Board Executive Secretary 
             P.O. Box 12233 RTP, NC 27709 
             Phone 919-541-3971

    Preliminary agenda includes Presentation of NTP FY 1995 Research and Testing 
    Plans and Interactive Discussion with the Board; review and action by the 
    Board on concepts for future contracts; brief reports from the NTP Director; 
    Environmental Toxicology Program Director; and updates on NTP grants, program 
    on alternative methods/ecotoxicology; Advisory Group on Toxicokinetics, 
    interagency collaborative studies, and Biennial Report on Carcinogens.

    The Board will recommend action on chemicals nominated and recommended for 
    study by the Interagency Committee for Chemical Evaluation and Coordination 
    (ICCEC) and time will be allowed for public comment on the chemicals as well. 
    Chemicals being considered for recommendation by the ICCEC prior to the Board 
    meeting are: Dimethyl adipate; 2,3 Butanedione; 2,2'-Dipyridyl; Methyl styryl 
    ketone; N-Bromosuccinimide; and 5-Nitroindazole.
    
--  NTP Board of Scientific Counselors Technical Reports Review 
    Subcommittee Meeting, November 29, 1994, 
    NIEHS Main Conference Facility, 111 Alexander Drive, 
    Research Triangle Park NC. 
    CONTACT: Dr. Larry Hart (address & phone shown above)

    The primary agenda topic will be public peer review of long-term study, 
    draft Technical Reports. Tentatively scheduled for review are: Two-year 
    study reports on 2,2-Bis (bromomethyl)-1,3-propanediol, isobutyl nitrite, 
    nickel oxide, nickel subsulfide, nickel sulfate hexahydrate, and 
    triethanolamine; short-term toxicity on 1-nitropyrene.

--  Request for chemical nominations for study by the NTP. 
    ANNOUNCEMENT ATTACHED. 
    CONTACT: Dr. Errol Zeiger 
             NIEHS/NTP 
             P.O. Box 12233 
             Research Triangle Park, NC 27709

--  Copy of the Federal Register notice announcing and requesting comment 
    on NTP's intent to conduct toxicological studies of 22 chemicals. 
    NOTICE ATTACHED 
    CONTACT: Dr. William Eastin 
             (See notice for address)

--  NIEHS announces grants program for the development of 
    mechanistically-based alternative methods. 
    CONTACT: Dr. Jerrold Heindel 
             NIEHS/DERT 
             P.O. Box 12233 
             Research Triangle Park, NC 27709 
             Phone 919-541-0781

    The NIEHS announces a request for applications (RFA) entitled 
    "Mechanistically-based Alternative Methods In Toxicology." 
    The announcement invites applications to conduct research to develop 
    mechanistically-based alternative methods and models for toxicological 
    research and testing. The RFA is being issued to foster the development, 
    validation, and use of improved testing and research methods that 
    either do not require the use of animals, that reduce the number of 
    animals, or that involve the use of alternatives such as non-mammalian 
    species. It is anticipated that improved testing methods that incorporate 
    new knowledge regarding the molecular and cellular mechanisms of toxicity 
    will be developed and validated, and existing test methods will be refined 
    to utilize new scientific information and techniques. Toxicological test 
    methods/model systems are encouraged in the priority areas of 
    carcinogenicity, neurotoxicity, and developmental toxicity, but will 
    be considered for any area of toxicity testing. Examples of alternative 
    methods and models that may be appropriate for development under this 
    program include genetically-engineered cell lines, non-mammalian and 
    invertebrate species, transgenic animals, and computer based prediction 
    and modeling systems. The anticipated funding level (total costs) is 
    $1.5 million per year for three years and it is estimated that eight 
    to ten grants will be awarded. The deadline for a letter of intent is 
    November 15, 1994, and applications must be received by December 20, 1994. 
    The anticipated date of award is July 1, 1995. To obtain a copy of the RFA, 
    contact Dr. Heindel.
    
--  NIEHS and NTP information in electronic format world-wide. 
    CONTACT: Dr. William Eastin 
             NIEHS/NTP 
             P.O. Box 12233 
             Research Triangle Park, NC 27709 
             Phone 919-541-7941

    In addition to contacting the NIEHS directly, the Institute makes available 
    selected information in electronic format world-wide. For example, the 
    NTP Annual Plan, The Annual Report on Carcinogens (Summary), 
    Abstracts of NTP Reports, and the Status of All NTP Studies
    are all available on the NIEHS Gopher Client Server. To view this 
    information requires access to the Internet and internet client 
    software, e.g., Gopher or Mosaic. The server is located at the 
    National Institute of Environmental Health Sciences, the address 
    is ntp.niehs.nih.gov.