Study Results & Research Projects

Summaries & Associations of Study Results

TR-429 Diethyl Phthalate

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http://ntp.niehs.nih.gov/go/9538

Target Organs and Levels of Evidence
NTP Technical Report Number 429

Produced from Chemtrack Database 09/19/01

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
DIETHYL PHTHALATE
84-66-2 		11/17/93 IN MANUFACTURE OF CELLULOID, COSMETICS, VARNISHES, AND DOPES. PLASTICIZER FOR CELLULOSE ESTER PLASTICS. INSECTICIDE SPRAYS. (TDB) Topical R: 0,100,300 M: 0,7.5,15,30 UL/100 UL SOLUTION /50 PER GROUP Hazleton Labs, Rockville, Gov't Services, Inc
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: NO EVIDENCE
OTHER :CONSIDERATIONS: LIVER: FATTY DEGENERATION 26/50 8/50 4/51
NON-NEOPLASTIC LESIONS: SKIN: ACANTHOSIS
FR: NO EVIDENCE
OTHER :CONSIDERATIONS: LIVER: FATTY DEGENERATION 23/50 11/50 3/50
MAMMARY GLAND: FIBROADENOMA 21/51 12/50 7/50
NON-NEOPLASTIC LESIONS: SKIN: ACANTHOSIS
MM: EQUIVOCAL EVIDENCE LIVER: ADENOMA 6/50 11/50 9/50 12/50 OR CARCINOMA 4/50 4/50 6/50 7/50 COMBINED 9/50 14/50 14/50 18/50
NON-NEOPLASTIC LESIONS: LIVER: BASOPHILIC FOCI
FM: EQUIVOCAL EVIDENCE LIVER: ADENOMA 4/50 12/51 14/50 10/50 OR CARCINOMA 4/50 5/51 6/50 3/50 COMBINED 7/50 16/51 19/50 12/50
DIETHYL PHTHALATE/DIMETHYL PHTHALATE
DIETH/DIMETH 		11/17/93 DIETHYL: CELLULOID MANUFACTURE, COSMETICS, VARNISHES, DOPES, INSECTICIDAL SOAPS, PLASTICIZER. DIMETHYL: INSECTICIDES, PLASTICIZER, SOLVENT, DYE CARRIER, ROCKET FUEL Topical 100 UL (PROMOTOR) NEAT CHEMICAL ON UNINITIATED AND DMBA INITIATED SKIN Hazleton Labs, Rockville, Gov't Services, Inc
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
NOTE: 1-YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE SWISS CD-1 MICE. THERE WAS NO EVIDENCE OF INITIATING OR PROMOTING ACTIVITY. MINOR DERMAL ACANTHOSIS WAS OBSERVED FOLLOWING 1 YEAR EXPOSURE TO DIETHYLPHTHALATE OR DIMETHYLPHTHALATE.

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