Nominations to the Testing Program
Nominations in Review 2001
Substances Recommended for Study:
Chemicals studied by the NTP are selected mainly on the basis of human exposure, production levels, chemical structure, and available toxicological data. Selection of an agent for a study does not imply that the agent is hazardous or a potential carcinogen in laboratory animals; likewise, an agent not selected for toxicological study by the Program should not be taken to mean that the agent is not potentially hazardous or potentially carcinogenic in laboratory rodents. Substances are identified by a common or generic name and CAS Registry No. where appropriate.
111 T.W. Alexander Drive
Research Triangle Park, NC
For information, questions or comments, contact:
Dr. Scott A. Masten
Office of Chemical Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
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Apigenin [520-36-5] |
National Cancer Institute |
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Naturally occurring flavonoid with potential oxidant and estrogenic activity; lack of toxicity information | No toxicological studies due to low potential for toxicity and human exposure |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Bladderwrack [68917-51-1],[84696-13-9] |
National Cancer Institute |
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|
Toxicological studies:
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Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
n -Butyl bromide [109-65-9] |
National Cancer Institute |
|
|
Consideration deferred pending receipt of manufacturers' voluntary testing plans |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Cylindrospermopsin [14345-90-8] |
National Institute of Environmental Health Sciences | Complete toxicological characterization |
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Toxicological studies:
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Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Dibenzofuran [132-64-9] |
National Cancer Institute |
|
|
No toxicological studies due to low commercial production volume and low potential for human exposure |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Diphenolic acid [126-00-1] |
National Cancer Institute |
|
|
No toxicological studies due to low commercial production volume and low potential for human exposure |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Epigallocatechin-3-gallate [989-51-5] |
National Cancer Institute |
|
Major polyphenol in green tea and green tea extract dietary supplements; potential chemopreventive agent; limited available toxicity information |
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
2-Ethylhexyl- p- dimethylaminobenzoic acid [21245-02-3] |
Private Individual |
|
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Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Grape seed and pine bark extracts | National Cancer Institute |
|
Significant human exposure through use as a dietary supplement; limited available toxicity information |
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Metalworking fluids | National Institute for Occupational Safety and Health |
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|
Toxicological studies:
Recommendations regarding further testing will be made after reviewing the results of NTP preliminary studies |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Methyl soyate [67784-80-9] |
National Cancer Institute |
|
|
Consideration deferred pending receipt of toxicity data development plans through existing or future regulatory programs |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Methyl tetrahydrofuran [96-47-9] |
National Cancer Institute |
|
Increasing use in alternative fuels; suspicion of toxicity and carcinogenicity based on structure; limited available toxicity information |
Toxicological studies
Consider dermal and inhalation routes of exposure |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Polybrominated diphenyl ethers
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Toxicological characterization including genotoxicity and neurotoxicity |
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Toxicological studies:
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Web page last updated on September 12, 2008