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Clinical Infectious Diseases
 ALPS
 Bacterial Pathogenesis
 Clinical Mycology
 Clinical Studies
 Database of Human HIES Mutations (STAT3base)
 Epidemiology Section
 Immunopathogenesis Section
 Medical Virology
 Molecular Microbiology
 Tuberculosis Research


Laboratory of Clinical Infectious Diseases

Steven M. Holland, M.D., Chief

The Laboratory of Clinical Infectious Diseases (LCID) conducts clinical and basic studies of important human infectious and immunologic diseases. Sections of the laboratory focus on mycobacterial, bacterial, viral, and fungal infections, as well as the acquired and congenital immune disorders associated with infection susceptibility and resistance. The program integrates clinical, cellular, and molecular investigation, including animal models and human natural history and therapeutic trials.

The defining feature of the LCID is the focus on patients and their infections in order to develop a comprehensive understanding of natural history, pathogenesis, pathophysiology, and management of diseases.

Training of physicians and scientists is central to the LCID mission. The NIAID infectious diseases training program and the NIH Clinical Center infectious disease consultation service are located in the LCID and are involved in all aspects of both clinical and laboratory activities. The integration of these programs into the LCID is critical to the reciprocal educations of basic scientists and clinical fellows alike.

The major themes of the laboratory center on infections that are recurrent or chronic, as these provide insight into both host and pathogen.

Selected Major Areas of Research

  • Immune defects of phagocytes
  • Cytokines in the pathogenesis and therapy of infections
  • Mechanisms of bacterial pathogenesis
  • Tuberculosis drug discovery, mechanisms of action, and resistance
  • Mechanism of action of existing and new antituberculosis agents
  • Mechanisms of fungal pathogenesis (Cryptococcus and Aspergillus)
  • Pathogenesis, treatment, and vaccines for human herpesviruses
  • Pathogenesis and treatment of autoimmune lymphoproliferative syndrome (ALPS)
  • Diagnosis and treatment of Lyme disease

Selected Clinical Protocols in the LCID

  • Natural history and therapies of bacterial, mycobacterial, fungal, or viral infections
  • Natural history and therapies of immune defects
  • Immune responses to infections and vaccines
  • Identification of novel bacteria, mycobacteria, viruses, fungi
  • Lyme disease
  • Autoimmune lymphoproliferative syndrome (ALPS)

Office of the Chief

Steven M. Holland, M.D.
Tara N. Palmore, M.D.

Autoimmune Lymphoproliferative Syndrome Unit

V. Koneti Rao, M.D.

Bacterial Pathogenesis Section

Sandip Datta, M.D.

Clinical Mycology Section

John E. Bennett, M.D.

Clinical Studies Unit

Adriana R. Marques, M.D.

Epidemiology Section

D. Rebecca Prevots, Ph.D., M.P.H.
Ruben Montes de Oca, M.S.
Amy E. Seitz, M.P.H.

Immunopathogenesis Section

Steven M. Holland, M.D.
Alexandra F. Freeman, M.D.
Kenneth N. Olivier, M.D.
Elizabeth Sampaio, M.D., Ph.D.
Gulbu Uzel, M.D.
Adrian Zelazny, M.D.

Infectious Disease Consultation Service

Juan Gea-Banacloche, M.D.

Infectious Disease Fellowship Training Program

John E. Bennett, M.D.
Tara N. Palmore, M.D.

Medical Virology Section

Jeffrey I. Cohen, M.D.
Lesia Dropulic, M.D.
Quingxiu Li, Ph.D.
Kening Wang, M.D. 

Molecular Microbiology Section

Kyung (June) Kwon-Chung, Ph.D.
Yun Chang, Ph.D. 

Tuberculosis Research Section

Clifton E. Barry, III, Ph.D.
Matthew Carroll, M.D.
Laura Via, Ph.D.

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Contact Info

Steven M. Holland, M.D., Chief
Phone: 301-402-7684
Fax: 301-480-4508
E-mail: smh@nih.gov
Mail:
Bldg. 10
CRC B3-4141
MSC 1684
Bethesda, MD 20892-1684

See Also

  • Division of Intramural Research (DIR)
  • Database of Human HIES Mutations (STAT3base)
  • Autoimmune Lymphoproliferative Syndrome (ALPS)
  • Immune System

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    The National Institute of Allergy and Infectious Diseases is a component of the National Institutes of Health, U.S. Department of Health and Human Services

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    Contact Info

    Steven M. Holland, M.D., Chief
    Phone: 301-402-7684
    Fax: 301-480-4508
    E-mail: smh@nih.gov
    Mail:
    Bldg. 10
    CRC B3-4141
    MSC 1684
    Bethesda, MD 20892-1684

    See Also

  • Division of Intramural Research (DIR)
  • Database of Human HIES Mutations (STAT3base)
  • Autoimmune Lymphoproliferative Syndrome (ALPS)
  • Immune System