Greg Riedlinger
Greg Riedlinger earned his B.S. from the University of Maryland in December 1998 and he started in our laboratory in the spring of 1999. He initially worked with Kay-Uwe Wagner on the deletion of the bcl-x gene in the hematopoietic system and they could demonstrate that Bcl-x is a essential for mature erythrocytes but not for immature erthrocytes. Subsequently, Greg has studied the role of Bcl-x on ovarian function using experimental mouse genetics. In collaboration with Keiko Miyoshi and Karen Cui, Greg isolated and characterized the Stat3/5 locus in the mouse genome. Those three scientists went on to generate mice in which this locus can be inactivated in specific cell types and at defined time points.
Greg left the lab in 2002 to pursue an M.D./Ph.D. at
Wake Forest University in Wiston-Salem, North Carolina. He just completed his first two years in Medical school and is now in the lab working on the Ph.D. part.
Publications whilst at LGP
1. Cui, Y., Riedlinger, G., Miyoshi, K., Tang, W., Li, C., Deng, C.-X., Robinson, G.W. and Hennighausen, L. (2004) Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival and differentiation. Mol. Cell. Biol., 24, 8037-8047.
2. Cui, Y., Bierie, B., Miyoshi, K., Riedlinger, G., Shillingford, J., Morgan, F., Robinson, G.W. and Hennighausen, L. (2003) Stat5 signaling in mouse mammary development and function: haploinsufficiency, compensation and the identification of target genes. Dev. Biol., under revision.
3. Wagner, K.U., Krempler, A., Qi, Y., Park, K., Henry, M.D., Triplett, A.A., Riedlinger, G., Rucker, III, E.B. and Hennighausen, L. (2003). Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol. Cell. Biol. 23:150-162.
4. Le Provost, F., Riedlinger, G., Hee Yim, S., Benedict, J., Gonzalez, F.J., Flaws, J. and Hennighausen L. (2002). The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility. Genesis 32:231-239.
5. Riedlinger, G., Okagaki, R., Wagner, K.U., Rucker, E.B. 3rd, Oka, T., Miyoshi, K., Flaws, J.A. and Hennighausen L. (2002). Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary. Biol. Reprod. 66:438-444.
6. Miyoshi, K., Cui, Y., Riedlinger, G., Robinson, P., Lehoczky, J., Zon, L., Oka, T., Dewar, K. and Hennighausen L. (2001). Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Genomics 71:150-155.
7. Wagner, K.U., Claudio, E., Rucker, E.B. 3rd, Riedlinger, G., Broussard, C., Schwartzberg, P.L., Siebenlist, U. and Hennighausen, L. (2000). Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development 127:4949-4958.
