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NCI announces a course for researchers using animal models: Mouse Research Models (MRM) or Mouse 101

Course evaluation now available

Overview:
Recent advances in cancer genomics have necessitated using the mouse as a research model. The importance of various genes can be evaluated by overexpressing them in transgenic mice or removing them in knockout mice. MRM or Mouse 101 explores how mouse research models can be used to evaluate the importance of various genes in carcinogenesis. Also, mouse research models can be used to evaluate the efficacy and/or toxicity of new drugs on the preclinical level. The course is designed for researchers who plan to conduct experiments using mouse research models at NIH.

The MRM course will be held on the Bethesda campus on Monday afternoons from 3-6 p.m. on May 2 and 23 in Bldg. 40, Rms. 1201/1203 and on May 9 and 16 in Bldg. 50, Rms. 1227/1233. MRM will provide an overview of the procedures used at NIH to conduct research using mice, mice databases and repositories, mouse genetics, effect of mouse phenotype, knockout and transgenic mice, speed congenics, imaging mice, murine histology and murine pathology. The participation of NIH postdoctoral fellows who plan to use mouse research models is encouraged.

Location and Time:
The MRM course will be held on the Bethesda campus on Monday afternoons from 3-6 p..m. on May 2 and 23, 2005 in Bldg. 40, Rms. 1201/1203 and on May 9 and 16 in Bldg. 50, Rms. 1227/1233. The lectures will be videoconferenced to NCI-Frederick (Bldg. 549, Rm. A). A handout for each lecture will be distributed on site. The powerpoints of each lecture will be posted on the website.

Registration is now closed:
The deadline for Registration is April 27, 2005. For more information contact the course director, Dr. Terry Moody by (moodyt@mail.nih.gov) by FAX (301-480-4323) or by phone (301-451-9451). The first 50 registrants will be accepted.

Certificate:
There is no fee for this course. Participants, who register for the course, may receive a certificate of completion after signing in and attending the lectures.

Links and Related Training Opportunities:
This course is part of a developing curriculum for training NCI clinical and postdoctoral fellows. A course in Translational Research in Clinical Oncology (TRACO) is offered in the Fall on Monday afternoons. It focuses on the development new cancer therapies. TRACO complements other topics in human diseases and therapies covered in “Demystifying Medicine for PhDs” which occurs on Tuesday afternoons in the Spring. In February a 2 day course is offered on Statistical Analysis of Research Data (SARD) is offered for NCI Clinical and Postdoctoral fellows. For additional training opportunities at NCI see http://ccr.cancer.gov. At NIH, view http://www.training.nih.gov.

MRM Organizers:

MRM Faculty:
L. Michelle Bennett, PhD
John Dennis, DVM
Lionel Feigenbaum, PhD
Terry Moody, PhD
Jonathan Wiest,, PhD
M. Anver, PhD, DVM
H. Bedigian, PhD
L. Cook, MBA
J. Dennis, DVM
L. Feigenbaum, PhD
D. Haines, DVM
R. Hoyt, DVM
K. Hunter, PhD
N. Jenkins, PhD
M. Lewandoski, PhD
S. Libutti, MD
D. Naf, PhD
S. Sharan, PhD
M. Shrader, BSc
M. Simpson, PhD, DVM
K. Stump, DVM
T. Walsh, MD

Schedule and Speakers:

Date: Lecture:

Speaker:

May 2 Introduction
Mouse Genetics
Mouse Husbandry
Animal Health Monitoring
Animal Study Proposals
H. Bedigian
N. Jenkins
L. Cook, M. Shrader
J. Dennis
T. Walsh
May 9 Animal Surgery
Animal Microsurgery
Speed Congenics
BACs Recombination
K. Stump
R. Hoyt
D. Naf
S. Sharan
May 16 Transgenic Mice
Complex and Inducible Phenotypes
Effect of Strain on Phenotype
L. Feigenbaum
M. Lewandoski
K. Hunter
May 23 Imaging Mice
Tumor Imaging
Murine Histology
Murine Pathology
M. Simpson
S. Libutti
M. Anver
D. Haines
PowerPoint Presentations:
Presentations are available on the NCI network. If you have trouble downloading the presentation, contact the MRM webmaster.
Date added Title Size
4/28/2005 Mouse Genetics (Jenkins) 9Mb
4/28/2005 Introduction (Bedigian) 2Mb
5/2/2005 Mouse Husbandry (Cook) 4Mb
5/2/2005 Animal Study Proposals (Walsh) 4Mb
5/2/2005 Animal Health Monitoring (Dennis) 19Mb
5/6/2005 Animal Microsurgery (Hoyt) 1/2, 2/2 6Mb
5/6/2005 Speed Congenics (Naf) 1Mb
5/9/2005 Animal Surgery (Stump) 24Mb
5/9/2005 BACs Recombination (Sharan) 3Mb
5/13/2005 Complex and Inducible (Lewandoski) 31Mb
5/16/2005 Phenotypes (Hunter) 16Mb
5/16/2005 Transgenic Mice (Feigenbaum) 25Mb
5/23/2005 Murine Histology (Anver) 6Mb
5/23/2005 Murine Pathology (Haines) 10Mb
5/23/2005 Tumor Imaging (Libutti) 7Mb
5/23/2005 Imaging Mice (Simpson) 7Mb