DISEASE CHARACTERISTICS:

• Histologically confirmed melanoma

  • Stage III or IV disease
  • No primary ocular melanoma

• Stable disease (SD) or partial response (PR) after prior systemic chemotherapy completed at least 4 weeks ago

  • Patients whose second post-chemotherapy evaluation (performed at least 4 weeks after the first evaluation that demonstrated SD or PR AND within 2 weeks before study entry) of disease demonstrates continued tumor shrinkage are not eligible

  • Patients whose second evaluation shows disease progression are eligible unless one of the following is true:

    • Lactic dehydrogenase (LDH) ≥ 2 times upper limit of normal (ULN)
    • LDH > ULN AND is higher than the patient's highest value before systemic chemotherapy
    • Patient has developed a new tumor measuring > 1 cm in diameter
    • Sum of the longest diameters of the existing tumor has increased > 20%
• Evaluable or measurable disease
• Not potentially curable by surgery

• No active CNS metastases

  • Solitary brain metastasis allowed if completely resected or completely ablated with radiosurgery more than 1 month before study entry

PATIENT CHARACTERISTICS:

Age

• 16 and over

Performance status

• Karnofsky 60-100%

Life expectancy

• Not specified

Hematopoietic

• WBC ≥ 3,000/mm^3
• Platelet count ≥ 100,000/mm^3
• No active bleeding

Hepatic

• See Disease Characteristics
• Bilirubin ≤ 2.0 mg/dL

Renal

• Creatinine ≤ 1.2 mg/dL

Cardiovascular

• Patients ≥ 50 years of age OR those with one or more cardiac risk factors must demonstrate one of the following:

  • Normal exercise stress test
  • Normal stress thallium test
  • Normal comparable cardiac ischemia evaluation
• LVEF ≥ 40%

Other

• No active infection requiring treatment
• No concurrent medical or psychiatric condition that would increase the potential toxicity of study treatment
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective barrier contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy

• No other concurrent antineoplastic biologic response modifier therapy
• No concurrent antineoplastic vaccine therapy

Chemotherapy

• See Disease Characteristics
• No concurrent antineoplastic chemotherapy

Endocrine therapy

• No concurrent steroidal antiemetics
• No concurrent systemic corticosteroids

Radiotherapy

• See Disease Characteristics
• No concurrent antineoplastic radiotherapy

Surgery

• See Disease Characteristics
• Recovered from prior surgery
• Surgery within the past 4 weeks allowed provided there is no evidence of disease progression

Other

• More than 4 weeks since prior therapy for melanoma
• No other concurrent antineoplastic experimental therapy