Low Dose of Midazolam is Superior to Conventional Dose for Rapid Sequence Intubation in Emergency Department (ED)

This study is currently recruiting participants.

Verified by Seoul National University Hospital, October 2008

Sponsored by:	Seoul National University Hospital
Information provided by:	Seoul National University Hospital
ClinicalTrials.gov Identifier:	NCT00783731

Purpose

Midazolam has been used in rapid sequence intubation for a long time, and the recommended dose is 0.1mg/kg. In some studies, however, the reduced dose has been used with the concern of hemodynamic instability. We would like to investigate that the low dose midazolam could be used rather than the standard recommended dose, and also compare it to the etomidate, recently used sedatives, with respect to the side effects and the easy performance of intubation.

Condition	Intervention
Intubation	Drug: Low dose midazolam

Drug Information available for: Midazolam Midazolam hydrochloride Midazolam maleate

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment

Further study details as provided by Seoul National University Hospital:

Study Start Date:

October 2008

Arms	Assigned Interventions
Low dose midazolam: Experimental	Drug: Low dose midazolam

Eligibility

Ages Eligible for Study:	18 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

patients who need rapid sequence intubation in emergency room

Exclusion Criteria:

in hypotension(systolic blood pressure less than 90 mmHg
severe trauma patients
pregnant
allergic to midazolam, etomidate

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00783731

Contacts

Contact: Kyuseok Kim, MD, PhD

+82-31-787-3049

dremkks@snubh.org

Locations

Korea, Republic of
Boramae Medical Center	Recruiting
Seoul, Korea, Republic of, 156-707
Contact: Joong Sik Jeong, MD +-82-870-1119 drlunch@medimail.co.kr
Korea, Republic of, Gyeonggi-do
Seoul National University Bundang Hospital, Emergency room	Recruiting
Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707
Contact: Tae Youn Kim, MD +82-31-787-7573 emkity@snubh.org

Sponsors and Collaborators

Seoul National University Hospital

More Information

Study ID Numbers:	RSI study
Study First Received:	October 30, 2008
Last Updated:	October 31, 2008
ClinicalTrials.gov Identifier:	NCT00783731
Health Authority:	Korea: Food and Drug Administration

Keywords provided by Seoul National University Hospital:

intubation

Study placed in the following topic categories:

Emergencies
Midazolam

Additional relevant MeSH terms:

Anesthetics, Intravenous
Neurotransmitter Agents
Tranquilizing Agents
Molecular Mechanisms of Pharmacological Action
GABA Modulators
Physiological Effects of Drugs
Psychotropic Drugs
Central Nervous System Depressants
Anesthetics

Pharmacologic Actions
Adjuvants, Anesthesia
Anesthetics, General
Therapeutic Uses
Hypnotics and Sedatives
GABA Agents
Anti-Anxiety Agents
Central Nervous System Agents

ClinicalTrials.gov processed this record on January 16, 2009