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Sponsored by: |
National Institute of Cancerología |
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Information provided by: | National Institute of Cancerología |
ClinicalTrials.gov Identifier: | NCT00402090 |
TPMT is a key enzyme in the metabolism of thiopurines. TPMT polymorphisms have been described and are associated with a decrease activity of such enzyme. Therefore, a higher risk of developing toxicity is present in patients requiring these drugs, which are indicated in acute lymphoblastic leukemia, as well as, immunosuppressors after organ transplantation. The frequency of heterozygotes polymorphisms ranges from 3 till 12 %, in different populations. Homozygous patients have a lower frequency, estimated 1 in 300 individuals. The frequency of such polymorphisms in mestizos mexican population has not been analyzed, and we considered important to determine this frequency in healthy and patients requiring thiopurines, particularly acute lymphoblastic leukemia.
Condition |
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Acute Lymphoblastic Leukemia |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Convenience Sample, Prospective Study |
Official Title: | Prevention of Thiopurines Related Toxicity Through the Determination by DHPLC TPMT Polymorphisms in Patients With ALL. |
Estimated Enrollment: | 160 |
Study Start Date: | April 2005 |
Estimated Study Completion Date: | November 2006 |
Objectives: Determine by DHPLC analysis the frequency of TPMT polymorphisms in mestizos mexican population with acute lymphoblastic leukemia.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Myrna Candelaria, MD | (52)55-56280479 | myrnac@prodigy.net.mx |
Mexico, DF | |
National Institute of Cancerologia | Recruiting |
MExico city, DF, Mexico, 14080 | |
Contact: Myrna Candelaria, MD (52)55-5628-04-79 myrnac@prodigy.net.mx | |
Principal Investigator: Myrna Candelaria, MD |
Principal Investigator: | Myrna Candelaria, MD | National Institute of Cancerologia |
Study ID Numbers: | 005/007/ICI, CONACYT: Salud-2004-01-005 |
Study First Received: | November 17, 2006 |
Last Updated: | November 17, 2006 |
ClinicalTrials.gov Identifier: | NCT00402090 |
Health Authority: | Mexico: Ethics Committee |
thiopurines thiopurine methyl transferase toxicity pharmacogenomics |
Lymphatic Diseases Leukemia Leukemia, Lymphoid Immunoproliferative Disorders |
Precursor Cell Lymphoblastic Leukemia-Lymphoma Lymphoproliferative Disorders Lymphoma |
Neoplasms Neoplasms by Histologic Type Immune System Diseases |