Assessment of the Ability to Distinguish Odors in Glaucoma Patients - Full Text View

Sponsored by:	University Hospital, Basel, Switzerland
Information provided by:	University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:	NCT00304824

Purpose

Glaucoma is one of the leading causes of blindness worldwide. The key feature of glaucoma is damage to the optic nerve head with loss of retinal ganglion cells and local tissue remodeling. Neuronal cell death in glaucoma occurs by apoptotic mechanisms1. Apoptosis of neurons also plays a major role in neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. An association between glaucoma and these disorders has been described 2-4. Furthermore, it has been reported that the olfactory function is disturbed in these neurodegenerative diseases5-6. We hypothesize that similar olfactory alterations may occur in glaucoma which is in fact a local neurodegenerative disease.

Condition
Glaucoma

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Degenerative Nerve Diseases Glaucoma

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case-Only, Prospective
Official Title:	Olfactory Function in Glaucoma Patients

Further study details as provided by University Hospital, Basel, Switzerland:

Biospecimen Retention: None Retained

Biospecimen Description:

Enrollment:	30
Study Start Date:	October 2004
Study Completion Date:	November 2005

Show Detailed Description

Eligibility

Ages Eligible for Study:	17 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

glaucoma patients

Criteria

Inclusion Criteria:

Chronic open-angle glaucoma with typical glaucomatous disc and visual field damage.

Exclusion Criteria:

Occludable iridocorneal angles
History of current, chronic or recurrent inflammatory eye disease
History of retinal or neuroophthalmologic disease that could result in visual field defects
Need for any concomitant medications that may interfere with the evaluation of olfactory function
Patients with a significant history and/or active alcohol or drug abuse (significant is defined as that which in the opinion of the investigator may either put the patient at risk because of participation in the study or may influence the results of the study or the patient's ability to participate in the study), smokers
History of olfactory disturbance related to identifiable local factors and any local condition that could lead to hyposmia/anosmia or interfere with the olfactory function, such as polyps, chronic sinus infection, sub(acute) viral or bacterial infection, history of sinus surgery

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00304824

Sponsors and Collaborators

University Hospital, Basel, Switzerland

Investigators

Study Director:

Selim Orgul

University Eye Hospital Basel, Switzerland

More Information

University Basel, Switzerland This link exits the ClinicalTrials.gov site

Responsible Party:	University Hospital, Basel, Switzerland ( Selim Orgül, MD )
Study ID Numbers:	009-Guk-2004-002
Study First Received:	March 17, 2006
Last Updated:	September 25, 2008
ClinicalTrials.gov Identifier:	NCT00304824
Health Authority:	Switzerland: Swissmedic

Keywords provided by University Hospital, Basel, Switzerland:

Glaucoma
Olfactory functions
Sniffing Sticks Test

Study placed in the following topic categories:

Glaucoma
Eye Diseases
Hypertension
Ocular Hypertension

ClinicalTrials.gov processed this record on January 16, 2009