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Sponsors and Collaborators: |
University of Rochester National Institutes of Health (NIH) VirtualScopics, Inc. |
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Information provided by: | University of Rochester |
ClinicalTrials.gov Identifier: | NCT00595803 |
The purpose of this study is to better understand the reason why people with injuries to their knee meniscus(cartilage) are at a higher risk for osteoarthritis later in life.
Condition |
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Meniscal Tear in Knee |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Chondrocyte Maturation and Cartilage Loss Following Meniscal Injury |
torn portion of meniscus, articular cartilage, joint fluid
Estimated Enrollment: | 42 |
Study Start Date: | August 2006 |
Estimated Study Completion Date: | August 2010 |
Estimated Primary Completion Date: | August 2010 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
Participants requiring articular cartilage debridement during arthroscopy.
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2
Participants with no significant articular cartilage lesions.
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After arthorscopic meniscal surgery, some patients develop arthritis over the following one or two decades, while others do not. We have identified a gene which may become "turned on" in the cartilage of the knee joint after an injury and which may cause cartilage deterioration. The degree to which this happens in different individuals may determine who is at risk for arthritis after meniscal injury. Thus we hope to develop tests to identify individuals at high risk at the time of injury so that preventative meaures might be taken to decrease their chance of developing arthritis.
Patients who participate in the study will undergo standard arthroscopy procedures and will be followed for a longer time period than typical patients. Participants will have MRI scans a month after surgery and 3 years postoperatively, in addition to routine annual clinic visits and radiographs during the 3 year follow-up period.
Ages Eligible for Study: | 20 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Patients with an isolated medial meniscus tear presenting in the general practice of one the study investigators.
Inclusion Criteria:
Exclusion Criteria:
Contact: Kelly Unsworth, MS | 585-273-1465 | Kelly_Unsworth@urmc.rochester.edu |
United States, New York | |
University of Rochester | Recruiting |
Rochester, New York, United States, 14642 | |
Sub-Investigator: Michael Maloney, MD | |
Sub-Investigator: Barbara Gracious, MD | |
Sub-Investigator: Johnny Monu, MD |
Principal Investigator: | Randy Rosier, MD, PhD | University of Rochester |
Responsible Party: | University of Rochester ( Randy Rosier, MD, PhD ) |
Study ID Numbers: | 14578, P50AR054041 |
Study First Received: | January 7, 2008 |
Last Updated: | September 29, 2008 |
ClinicalTrials.gov Identifier: | NCT00595803 |
Health Authority: | United States: Institutional Review Board |
Meniscus Osteoarthritis Smurf2 |
Lacerations Osteoarthritis |