Effect of Stress on Heroin-Related Memory Retrieval

This study has been completed.

Sponsored by:	National Institute on Drug Dependence, China
Information provided by:	National Institute on Drug Dependence, China
ClinicalTrials.gov Identifier:	NCT00759005

Purpose

The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

Condition	Intervention
Heroin Dependence Learning and Memory	Drug: propranolol and cortisol

MedlinePlus related topics: Heroin Memory

Drug Information available for: Hydrocortisone Cortisol 21-phosphate Cortisol succinate Hydrocortamate Hydrocortisone 21-sodium succinate Hydrocortisone acetate Hydrocortisone cypionate Hydrocortisone hemisuccinate Proctofoam-HC Propranolol Dexpropranolol Propranolol hydrochloride Diacetylmorphine Diacetylmorphine hydrochloride

U.S. FDA Resources

Study Type:

Interventional

Further study details as provided by National Institute on Drug Dependence, China:

Primary Outcome Measures:

Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts [ Designated as safety issue: Yes ]

Study Start Date:	March 2007
Study Completion Date:	September 2008
Primary Completion Date:	June 2008 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
A, 4: Experimental	Drug: propranolol and cortisol

Eligibility

Ages Eligible for Study:	20 Years to 40 Years
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion Criteria:

current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00759005

Locations

China
National Institute on Drug Dependence
Beijing, China, 100191

Sponsors and Collaborators

National Institute on Drug Dependence, China

More Information

Study ID Numbers:	NIDD
Study First Received:	September 23, 2008
Last Updated:	September 23, 2008
ClinicalTrials.gov Identifier:	NCT00759005
Health Authority:	China: Peking University Research Ethics Committee

Study placed in the following topic categories:

Hydrocortisone
Propranolol
Cortisol succinate
Heroin
Mental Disorders
Heroin Dependence

Substance-Related Disorders
Disorders of Environmental Origin
Stress
Hydrocortisone acetate
Opioid-Related Disorders

Additional relevant MeSH terms:

Vasodilator Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Adrenergic Agents
Therapeutic Uses
Physiological Effects of Drugs

Adrenergic beta-Antagonists
Adrenergic Antagonists
Cardiovascular Agents
Anti-Arrhythmia Agents
Antihypertensive Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 16, 2009