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Sponsored by: |
Peking University |
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Information provided by: | Peking University |
ClinicalTrials.gov Identifier: | NCT00378443 |
IgA nephropathy( IgAN) is the most common primary glomerulonephritis worldwide. Since the etiology of the disease is not clearly understood, no specific therapeutic strategies was defined for IgAN. Both ACEi/ARB and steroid was found to be effective in slowing the rate of disease progression, but the use of steroid was restricted because of its side effects. However, there is no evidence from RCT on the question of whether combined use of steroid with ACEi/ARB can bring more benefit to IgAN patients than ACEi/ARB alone. We therefore undertook a randomized, multicenter study to investigate the efficacy and safety profile of combined use of ACEi/ARB plus steroid compared with ACEi/ARB alone in the treatment of patients with IgAN.
Condition | Intervention |
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Glomerulonephritis, IGA |
Drug: prednisone + Inhibace/Cozaar Drug: Inhibace/Cozaar |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study |
Study Start Date: | January 2006 |
Estimated Study Completion Date: | June 2007 |
IgA nephropathy( IgAN) is the most common primary glomerulonephritis worldwide. Since the etiology of the disease is not clearly understood, no specific therapeutic strategies was defined for IgAN. In the many studies on the treatment of IgAN, both ACEi/ARB and steroid was found to be effective in slowing the rate of disease progression, but the use of steroid was restricted because of its side effects, and ACEi/ARB was considered to be the first line therapy. However, there is no evidence from RCT on the question of whether combined use of steroid with ACEi/ARB can bring more benefit to IgAN patients than ACEi/ARB alone. We therefore undertook a randomized, multicenter study to investigate the efficacy and safety profile of combined use of ACEi/ARB plus steroid compared with ACEi/ARB alone in the treatment of patients with IgAN.
Ages Eligible for Study: | 16 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | [2006]022 |
Study First Received: | September 19, 2006 |
Last Updated: | September 21, 2006 |
ClinicalTrials.gov Identifier: | NCT00378443 |
Health Authority: | China: Ethics Committee |
Prednisone Losartan Glomerulonephritis Autoimmune Diseases Urologic Diseases Nephritis |
Berger disease Glomerulonephritis, IGA Kidney Diseases Angiotensin II Cilazapril |
Angiotensin II Type 1 Receptor Blockers Molecular Mechanisms of Pharmacological Action Immune System Diseases Therapeutic Uses Angiotensin-Converting Enzyme Inhibitors Enzyme Inhibitors |
Anti-Arrhythmia Agents Cardiovascular Agents Antihypertensive Agents Pharmacologic Actions Protease Inhibitors |