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Sponsored by: |
Massachusetts General Hospital |
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Information provided by: | Massachusetts General Hospital |
ClinicalTrials.gov Identifier: | NCT00181792 |
The researchers will study 100 families over three years, each with a child (proband) between the ages of 12-17, with the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnosis of ADHD. The researchers hypothesize smoking will be familial and ADHD probands with a family history of tobacco use will be at increased risk for early initiation and persistence of smoking, compared to ADHD probands with no family history of tobacco use.
Study Type: | Observational |
Study Design: | Family-Based |
Official Title: | Family Risk Analysis of Substance Use in ADHD Youth Treated With Concerta |
Estimated Enrollment: | 100 |
Study Start Date: | May 2005 |
Estimated Primary Completion Date: | May 2010 (Final data collection date for primary outcome measure) |
As Attention Deficit Hyperactivity Disorder (ADHD) is a documented risk factor for smoking in adolescents, and as theoretical considerations suggest that ADHD and tobacco use may share common underlying mechanisms, the proposed study looks to examine the association between smoking and ADHD. Since both ADHD and smoking are known to be familial disorders, one approach to examine the nature of the association between the two disorders is to conduct a familial risk analysis comparing ADHD youth who smoke and ADHD youth who don't smoke. Another approach is to conduct a genetic study, to identify candidate genes associated with nicotine abuse and dependence in ADHD youth and relatives.
This study includes:
Ages Eligible for Study: | 6 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
First-degree relative between the ages of 6-55 years of a family member (proband) between the ages of 12-17 with the DSM-IV diagnosis of ADHD
Inclusion Criteria:
Contact: Meghan Kotarski, BS | 617-503-1051 | mkotarski@partners.org |
United States, Massachusetts | |
Massachusetts General Hospital | Recruiting |
Cambridge, Massachusetts, United States, 02138 | |
Contact: Meghan Kotarski, BS 617-503-1051 mkotarski@partners.org | |
Contact: Courtney Williams, BA 617-503-1089 cgwilliams@partners.org | |
Principal Investigator: Paul Hammerness, MD |
Principal Investigator: | Paul Hammerness, MD | Massachusetts General Hospital |
Responsible Party: | Massachusetts General Hospital ( Paul Hammerness, MD ) |
Study ID Numbers: | 2005-P-000278 |
Study First Received: | September 13, 2005 |
Last Updated: | July 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00181792 |
Health Authority: | United States: Institutional Review Board |
ADHD smoking familial risk |
Smoking Attention Deficit Disorder with Hyperactivity Mental Disorders Mental Disorders Diagnosed in Childhood |
Methylphenidate Attention Deficit and Disruptive Behavior Disorders Hyperkinesis |
Habits |