Inclusion Criteria:

• Men and women 20-75 years of age.
• The subjects will have a sitting systolic blood pressure measurement of 140-159 mm Hg (measured using JNC VI procedures) OR a prescription verified history of the use of stable (for 3 months) antihypertensive medication (certain drugs are excluded below). Potential subjects not on therapy who have a systolic BP of 140-159 mmHg will be advised on diet and lifestyle changes according to JNC VI guidelines prior to study participation.
• They must be able to give informed consent.

Exclusion Criteria:

• Subjects currently using lipid-lowering medication such as statins, niacin or gemfibrozil.
• Systolic BP > 159 mmHg or diastolic BP > 99 mmHg despite anti-hypertensive medication. Subjects who have blood pressure readings above these values will be given a trial of antihypertensive therapy for two weeks using the drugs hydrochlorthiazide and/or metoprolol with permission from them and their primary healthcare provider. If controlled, they will be allowed to enroll.
• Subjects on clonidine. Subjects on clonidine who express interest in the study will be considered if their primary health care provider permits the investigators to change them on to allowed antihypertensive medication, i.e., hydrochlorthiazide or metoprolol, and they meet enrollment criteria after two weeks of therapy.
• Subjects on ACE inhibitors or calcium channel blockers who express interest in the study will be considered if their primary health care provider permits the investigators to change them on to allowed antihypertensive medication, i.e., hydrochlorthiazide or metoprolol, and they meet enrollment criteria after two weeks of therapy. If beta-blocker/diuretic treatment is not effective or not tolerated, or if advised by the subject's primary health care provider, subjects may remain in the study on ACE inhibitors or calcium channel blockers.
• Subjects being treated with antifungal agents or the antibiotic erythromycin.
• Women using oral contraceptive drugs.
• Diabetic patients that are not on antihypertensive medication.
• Subjects who have EKG abnormalities during the screening visit, ischemic EKG abnormalities on stress testing, or history of prior diagnosis of ischemic heart disease, or use of digoxin, nitroglycerine/anti-anginal agents, theophylline-like drugs or antiarrhythmic medication.
• Subjects with a history of chronic obstructive airway disease, or evidence of such disease at clinical examination during the screening visit. (x) Persons who are current smokers.
• Subjects with abnormal liver and renal function tests at screening visit. - Women who are pregnant (by history or pregnancy test) or are planning pregnancy during the study period, or are nursing infants.
• Persons with severe obesity defined as BMI > 40 kg/m2.