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| Sponsored by: |
Imperial College London |
|---|---|
| Information provided by: | Imperial College London |
| ClinicalTrials.gov Identifier: | NCT00180804 |
Purpose
For implantation of developing conceptus, placental cells need to invade mother's uterus to access maternal blood supply in a control manner. We have found a combination of maternal immune genes (the KIR family) and fetal genes (HLA-C) strongly associated with pre-eclampsia where placenta does not implant adequately. The aim of this research is to investigate these two genes family in women suffering with recurrent miscarriages and find a possible link between them.
| Condition |
|---|
|
Recurrent Miscarriages |
| Study Type: | Observational |
| Study Design: | Natural History, Longitudinal, Defined Population, Retrospective/Prospective Study |
| Official Title: | Combination of Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages |
| Estimated Enrollment: | 400 |
| Study Start Date: | April 2005 |
| Estimated Study Completion Date: | August 2005 |
Little is known about reasons for early pregnancy failures. It is believed that some pathology leading to defective implantation of fetus in maternal uterus may lead to recurrent early miscarriages. This project arises from previous work on pre-eclampsia where we found combination of maternal immune genes (KIR) with their ligand (HLA-C) in the fetus was strongly associated with the disease. We will tissue type the fetus, mother and father in cases of unexplained miscarriages. We hope that genetic findings in recurrent miscarriage will lead to new insights, prevention and treatment.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Couples with 3 or more unexplained miscarriages
Exclusion Criteria:
Previous livebirths, parental karyotypic abnormalities, thrombophilic defects, uterine structural abnormalities
Contacts and Locations| Contact: Lesley Regan, FRCOG | 02078861050 | l.regan@imperial.ac.uk |
| United Kingdom | |
| St. Mary's Hospital | Recruiting |
| London, United Kingdom, W2 1NY | |
| Contact: Lesley Regan, FRCOG 02078861050 l.regan@imperial.ac.uk | |
| Principal Investigator: | Ashley Moffett, MRCP | University of Cambridge, UK |
| Principal Investigator: | Raj Rai, MRCOG | Imperial College London |
| Principal Investigator: | Preeti Jindal, MRCOG | St. Mary's NHS Trust, London |
| Principal Investigator: | Winnie Lo | St. Mary's NHS Trust, London |
More Information
| Study ID Numbers: | 05/MRE02/20 |
| Study First Received: | September 13, 2005 |
| Last Updated: | December 13, 2005 |
| ClinicalTrials.gov Identifier: | NCT00180804 |
| Health Authority: | United Kingdom: Research Ethics Committee |
|
Pregnancy Complications Abortion, Habitual Abortion, Spontaneous Recurrence |
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Disease Attributes Pathologic Processes |
