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Sponsors and Collaborators: |
Imperial College London CORE St Mark's Hospital Foundation |
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Information provided by: | Imperial College London |
ClinicalTrials.gov Identifier: | NCT00180648 |
The purpose of this study is to investigate the theory that the plasma level of Glucagon like peptide 2 (GLP-2) in patients with intestinal failure can predict their clinical recovery.
Condition |
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Short Bowel Syndrome |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Defined Population, Prospective Study |
Official Title: | Plasma Determination of Glucagon-Like Peptide 2 as a Predictor of Recovery in Adults With Acute Intestinal Failure |
Estimated Enrollment: | 30 |
Study Start Date: | February 2005 |
Estimated Study Completion Date: | February 2008 |
When major segments of small bowel have been removed surgically, or damaged by disease, the length of the residual bowel may be inadequate to maintain overall nutrition and the net result is described as "intestinal failure".
Without medical intervention, patients with intestinal failure become malnourished and dehydrated because their remaining intestine is unable to absorb enough water, vitamins and other nutrients from the ingested food. Intravenous feeding offers life saving treatment but causes complications like infections and liver problems. It also poses enormous strain on day to day life.
Glucagon like peptide 2 (GLP-2) is a naturally occurring hormone (or chemical messenger) that is able to increase the surface area of the intestinal lining (or mucosal mass) and the absorptive efficiency of the remaining intestine.
Intestinal failure patients in whom not only parts of the small bowel but also the large bowel have had to be surgically removed have been shown to have a markedly impaired rise in GLP-2 levels following meals, in contrast to patients with a preserved large bowel who have increased levels of GLP-2 and are known to have much better functional adaptation.
From this we hypothesise that the GLP-2 level is directly related to, and could predict, clinical recovery in intestinal failure as measured by Amount of parenteral nutrition required Length of hospital stay Mortality
We also aim to compare GLP-2 levels of patients with acute intestinal failure with that of patients with chronic intestinal failure as well as healthy controls
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Katharina Wallis | katharina.wallis@ic.ac.uk |
United Kingdom, Middlesex | |
St Mark's Hospital | Recruiting |
Harrow, Middlesex, United Kingdom, HA1 3UJ | |
Contact: Katharina Wallis, MD 0044 797 101 4634 katharina.wallis@ic.ac.uk | |
Sub-Investigator: Katharina Wallis, MD |
Principal Investigator: | Alastair Forbes | University College London Hospitals |
Study ID Numbers: | 04/Q0405/83 |
Study First Received: | September 12, 2005 |
Last Updated: | September 12, 2005 |
ClinicalTrials.gov Identifier: | NCT00180648 |
Health Authority: | United Kingdom: Research Ethics Committee |
Short Bowel Syndrome Intestinal Failure Glucagon Like Peptide 2 Parenteral Nutrition |
Digestive System Diseases Postoperative Complications Gastrointestinal Diseases Glucagon |
Malabsorption Syndromes Short Bowel Syndrome Intestinal Diseases |
Disease Pathologic Processes Therapeutic Uses Syndrome Physiological Effects of Drugs |
Gastrointestinal Agents Hormones, Hormone Substitutes, and Hormone Antagonists Hormones Pharmacologic Actions |