Prophylaxis of Ventilator Associated Pneumonia by Continuous Lateral Rotation Therapy - Full Text View

Sponsored by:	Medical University of Vienna
Information provided by:	Medical University of Vienna
ClinicalTrials.gov Identifier:	NCT00529776

Purpose

Hypothesis: Ventilator associated pneumonia (VAP) in critically ill patients may be prevented by continuous lateral rotation therapy (CLRT) using specially designed, motor driven beds.

Patients are randomized to CLRT or supine position if mechanically ventilated and not suffering from pneumonia or ARDS within 48 hours after intubation. Prophylaxis of VAP is standardized in both groups. Primary endpoint is incidence of VAP, secondary endpoints are length of ventilation, length of stay and mortality.

Condition	Intervention
Pneumonia, Ventilator-Associated	Procedure: Continuous lateral rotation therapy

MedlinePlus related topics: Pneumonia

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Prevention, Randomized, Single Blind (Outcomes Assessor), Active Control, Parallel Assignment, Efficacy Study
Official Title:	Prophylaxis of Ventilator Associated Pneumonia by Continuous Lateral Rotation Therapy

Further study details as provided by Medical University of Vienna:

Primary Outcome Measures:

Ventilator associated pneumonia

Secondary Outcome Measures:

Length of hospital stay
Length of mechanical ventilation
ICU and hospital Mortality

Enrollment:	150
Study Start Date:	September 2005
Study Completion Date:	May 2008

Arms	Assigned Interventions
1: Active Comparator Continuous lateral rotation therapy	Procedure: Continuous lateral rotation therapy
2: No Intervention Standard manual positioning (Supine position)

Eligibility

Ages Eligible for Study:	18 Years to 89 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Mechanically ventilated
Intubated not longer than 48 h
Medical cause for ICU admission
Expected to be ventilated for > 48 hours

Exclusion Criteria:

Pneumonia or ARDS present
Postoperative patient

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00529776

Locations

Austria
Vienna General Hospital, Medical University of Vienna
Vienna, Austria, 1090

Sponsors and Collaborators

Medical University of Vienna

Investigators

Principal Investigator:	Thomas Staudinger, MD	Department of Internal Medicine I, Medical University of Vienna, Austria
Principal Investigator:	Thomas Staudinger, MD	Dept. of Internal Medicine I, Medical University of Vienna

More Information

Responsible Party:	Medical University of Vienna ( Thomas Staudinger )
Study ID Numbers:	EK 38/2004
Study First Received:	September 12, 2007
Last Updated:	June 10, 2008
ClinicalTrials.gov Identifier:	NCT00529776
Health Authority:	Austria: Federal Ministry for Health and Women

Keywords provided by Medical University of Vienna:

Prevention of ventilator associated pneumonia

Study placed in the following topic categories:

Respiratory Tract Infections
Respiratory Tract Diseases
Lung Diseases

Pneumonia, Ventilator-Associated
Cross Infection
Pneumonia

Additional relevant MeSH terms:

Infection

ClinicalTrials.gov processed this record on January 15, 2009