Spotlight On…

Aminoflavone Prodrug (NSC 710464)
The parent aminoflavone (NSC 686288) showed good differential activity in the NCI 60-cell line screen and marked effects in renal xenografts. More…

Batracylin (NSC 320846)
Batracylin reached Stage 3 of the NCI pipeline, but was dropped in 1989 because of concern about the interspecies differences in toxicity and potential for variable oral absorption. More…

Halichondrin B analog (NSC 707389)
Work done on synthesizing halicondrin B (NSC 609395) showed that only a portion of the molecule was needed for potent biological activity. More…

SAHA (NSC 701852)
SAHA is a potent histone deactylase (HDAC) inhibitor with excellent oral bioavailability. More…

Coordinating Center for Clinical Trials (CCCT)
An NCI office that seeks to enhance the best of all the components of the NCI-supported clinical trials system… More…

Clinical Trials Advisory Committee (CTAC)
An external NCI committee that shall provide advice to NCI on the NCI-supported national clinical trials enterprise… More…

Clinical Trials Operations Committee (CTOC)
An internal NCI committee… More…

Clinical Trials Working Group (CTWG)
The Clinical Trials Working Group (CTWG), which made recommendations to revamp the NCI’s cancer clinical trials system, spawned a new NCI organizational structure… More…

Preoperative Therapy in Invasive Breast Cancer
Meeting March 26-27, 2007

NCI’s Clinical Trials Cooperative Groups National Meeting Report