Failure of Implantation After Recurrent Embryo Transfers - Full Text View

Sponsored by:	UMC Utrecht
Information provided by:	UMC Utrecht
ClinicalTrials.gov Identifier:	NCT00351481

Purpose

We will investigate maternal and embryonic factors in women with recurrent implantation failure, undergoing IVF/ ICSI treatment. Women who have not achieved a pregnancy after three embryo transfer procedures will undergo an endometrial biopsy during the window of implantation in a natural cycle. During the next treatment cycle we will aspirate endometrial secretion and perform a doppler ultrasound investigation of the a. uterina. Moreover, we will investigate the cytokine expression from the transferred embryo from the culture medium.

Condition
Infertility

MedlinePlus related topics: Infertility

U.S. FDA Resources

Study Type:	Observational
Official Title:	Recurrent Embryo Implantation Failure in Women Undergoing IVF/ ICSI; an Investigation of the Intra-Uterine Environment During the Window of Implantation

Further study details as provided by UMC Utrecht:

Estimated Enrollment:	80
Study Start Date:	July 2006
Study Completion Date:	May 2008
Primary Completion Date:	May 2008 (Final data collection date for primary outcome measure)

Show Detailed Description

Eligibility

Ages Eligible for Study:	18 Years to 37 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Women who have not achieved a pregnancy, despite 3 subsequent embryo transfers, of which only one is allowed to be a transfer of a cryo-thawed embryo. A chemical pregnancy or E.U.G. will not be regarded as a pregnancy. An abortion will be regarded as a pregnancy.

Exclusion Criteria:

women older than 37 years.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00351481

Locations

Netherlands
University Medical Center Utrecht
Utrecht, Netherlands, 3584CX

Sponsors and Collaborators

UMC Utrecht

Investigators

Study Chair:

Nick Macklon, Professor

University Medical Center Utrecht

More Information

Publications:

van der Gaast MH, Beier-Hellwig K, Fauser BC, Beier HM, Macklon NS. Endometrial secretion aspiration prior to embryo transfer does not reduce implantation rates. Reprod Biomed Online. 2003 Jul-Aug;7(1):105-9.

Study ID Numbers:	FIRE-study
Study First Received:	July 12, 2006
Last Updated:	May 28, 2008
ClinicalTrials.gov Identifier:	NCT00351481
Health Authority:	Netherlands: Medical Ethics Review Committee (METC)

Keywords provided by UMC Utrecht:

IVF
endometrial receptivity
embryo implantation
recurrent implantation failure

Study placed in the following topic categories:

Genital Diseases, Female
Infertility
Genital Diseases, Male
Recurrence

ClinicalTrials.gov processed this record on January 14, 2009