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Sponsors and Collaborators: |
Laval University AstraZeneca |
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Information provided by: | Laval University |
ClinicalTrials.gov Identifier: | NCT00691951 |
A reduced response to inhaled corticosteroids (ICS) has been reported in smoking compared to non-smoking asthmatic patients. However, the comparative response to other currently prescribed medications such as combination therapy of long-acting beta agonists and ICS remain to be further evaluated.
No significant differences were found between our group of subjects in regard to changes in asthma control pulmonary function and airway inflammation following budesonide or the association of budesonide with formoterol for a period of 2 months. This should be further explored in larger groups of subjects.
Condition | Intervention | Phase |
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Asthma |
Drug: budesonide and budesonide/formoterol |
Phase III |
Study Type: | Interventional |
Official Title: | Comparative Effects of Budesonide and Budesonide/Formoterol (Symbicort) on Asthma Control in Smoking Asthmatic Subjects: A Pilot Study |
Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | Laval University ( Louis-Philippe Boulet ) |
Study ID Numbers: | Symbicort smokers AZ |
Study First Received: | June 4, 2008 |
Last Updated: | October 17, 2008 |
ClinicalTrials.gov Identifier: | NCT00691951 |
Health Authority: | Canada: Canadian Institutes of Health Research |
Smoking Hypersensitivity Lung Diseases, Obstructive Symbicort Respiratory Tract Diseases Lung Diseases |
Budesonide Hypersensitivity, Immediate Formoterol Asthma Respiratory Hypersensitivity |
Anti-Inflammatory Agents Respiratory System Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Adrenergic Agents Adrenergic beta-Agonists Bronchial Diseases Immune System Diseases Physiological Effects of Drugs Hormones, Hormone Substitutes, and Hormone Antagonists |
Anti-Asthmatic Agents Glucocorticoids Hormones Adrenergic Agonists Pharmacologic Actions Autonomic Agents Therapeutic Uses Peripheral Nervous System Agents Bronchodilator Agents |