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Robert L. Dedrick, Ph.D. Chemical Engineer/Special Volunteer Drug Delivery and Kinetics Laboratory of Bioengineering and Physical Science Bldg. 13, Rm. 3W 10C Tel: 301-435-9327 Fax: 301-496-6608 E-mail: dedrickr@mail.nih.gov

• Research Interest and Expertise
• Selected Publications
• Books
• Patents

Research Interest and Expertise

• Physiological pharmacokinetic modeling of drugs, environmental contaminants and macromolecules

• Regional drug delivery including intra-arterial and intracavitary approaches with particular emphasis on the mechanisms of transport in the brain and peritoneal cavity

• Application of model systems in pharmacokinetics such as interspecies scaling, invitro to in vivo correlations, and pharmacokinetically based clinical trials

Selected Recent Publications

• Nguyen TT, Pannu YS, Sung C, Dedrick RL, Walbridge S, Brechbiel MW, Garmestani K, Beitzel M, Yordanov AT, Oldfield EH: Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging. J Neurosurg, 98:584-590, 2003.

• Lutz RJ, Warren K, Balis F, Patronas N, Dedrick RL: Mixing during intravertebral infusions in an in vitro model. J Neuro-Oncology, 58:95-106, 2002.

• Fox E, Bungay PM, Bacher J, McCully CL, Dedrick RL, Balis FM: Zidovudine concentration in brain extracellular fluid measured by microdialysis: steady-state and transient results in rhesus monkey. J Pharmacol Exp Ther, 301:1003-1011, 2002.

• Dedrick RL. Animal scale-up. In Atkinson AJ, Daniels CE, Dedrick RL, Grudzinskas CV, Markey SP (eds): Principles of Clinical Pharmacology. Academic Press, New York, 2001, pp 387-393.

• Steller , MA , Egorin MJ, Trimble EL, Bartlett DL, Zuhowski EG, Alexander HR, Dedrick RL: A pilot phase I trial of continuous hyperthermic peritoneal perfusion with high-dose carboplatin in patients with small volume residual ovarian cancer. Cancer Chemother Pharmacol, 43:106-114, 1999.

Books

• Atkinson AJ, Daniels CE, Dedrick RL, Grudzinskas CV, Markey SP (eds): Principles of Clinical Pharmacology. Academic Press, New York, 2001.

• Teorell T, Dedrick RL, Condliffe P (eds): Pharmacology and Pharmacokinetics. Plenum Press, New York, 1974.

Patents

• Laske DW, Oldfield EH, Bobo RH, Dedrick RL, Morrison PF: Convection-enhanced drug delivery. U. S. Patent No 5,720,720, February 24, 1998.

• Dedrick RL, Lutz RJ, Zaharko DS: Apparatus for Controlling the Release of a Drug. U. S. Patent No 3,946,734, March 30, 1976.

• Knazek RA, Gullino PM, Dedrick RL, Kidwell WR: Cell Culture on Semipermeable Tubular Membranes. U. S. Patent No 3,883,393, May 13, 1975.

• Knazek RA, Gullino PM, Dedrick, RL, Kidwell WR: Cell Culture on Semipermeable Tubular Membranes. U. S. Patent No 3,821,087, June 28, 1974.

• Kolobow T, Dedrick RL: Dialysate Capacity Augmentation Process. U. S. Patent No 3,463,728, August 26, 1969.