Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
Radiation Therapy Oncology Group National Cancer Institute (NCI) |
---|---|
Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00006360 |
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells.
PURPOSE: Phase I/II trial to study the effectiveness of radiation therapy in treating patients who have stage II or stage III oropharyngeal cancer.
Condition | Intervention | Phase |
---|---|---|
Cancer-Related Problem/Condition Head and Neck Cancer |
Procedure: radiation therapy Procedure: radioprotection |
Phase I Phase II |
Study Type: | Interventional |
Study Design: | Treatment |
Official Title: | Conformal and Intensity Modulated Irradiation for Oropharyngeal Cancer |
Study Start Date: | February 2001 |
OBJECTIVES:
OUTLINE: This is a multicenter study.
Patients receive 3-D conformal radiotherapy and/or intensity-modulated radiotherapy daily 5 days a week for 6 weeks, in an effort to spare major salivary glands.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.
PROJECTED ACCRUAL: Approximately 57-64 patients will be accrued for this study over 27 months.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Histologically proven stage II or III (T1-T2, N0-N1) squamous cell carcinoma of the oropharynx (tonsil, base of tongue, or palate)
Measurable or evaluable disease
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
Other:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Other:
United States, Arizona | |
Foundation for Cancer Research and Education | |
Phoenix, Arizona, United States, 85013 | |
United States, California | |
UCSF Comprehensive Cancer Center | |
San Francisco, California, United States, 94115 | |
United States, Florida | |
University of Florida Shands Cancer Center | |
Gainesville, Florida, United States, 32610-0385 | |
United States, Michigan | |
University of Michigan Comprehensive Cancer Center | |
Ann Arbor, Michigan, United States, 48109-0010 | |
United States, Missouri | |
CCOP - Kansas City | |
Kansas City, Missouri, United States, 64131 | |
United States, New Jersey | |
Community Regional Cancer Center at Community Medical Center | |
Toms River, New Jersey, United States, 08755 | |
Monmouth Medical Center | |
Long Branch, New Jersey, United States, 07740-6395 | |
United States, Pennsylvania | |
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | |
Philadelphia, Pennsylvania, United States, 19107-5541 | |
United States, Texas | |
M.D. Anderson Cancer Center at University of Texas | |
Houston, Texas, United States, 77030-4009 | |
United States, Utah | |
Dixie Regional Medical Center | |
Saint George, Utah, United States, 84770 | |
LDS Hospital | |
Salt Lake City, Utah, United States, 84143 | |
United States, Vermont | |
Community Cancer Center at Rutland Regional Medical Center | |
Rutland, Vermont, United States, 05701 | |
United States, Wisconsin | |
All Saints Cancer Center at All Saints Healthcare | |
Racine, Wisconsin, United States, 53405 | |
CCOP - Marshfield Clinic Research Foundation | |
Marshfield, Wisconsin, United States, 54449 | |
Medical College of Wisconsin Cancer Center | |
Milwaukee, Wisconsin, United States, 53226 | |
Canada, Alberta | |
Stollery Children's Hospital at University of Alberta Hospital | |
Edmonton, Alberta, Canada, T6G 2R7 | |
Canada, Quebec | |
Centre Hospitalier de l'Universite de Montreal | |
Montreal, Quebec, Canada, H2L 4MI | |
McGill Cancer Centre at McGill University | |
Montreal, Quebec, Canada, H2W 1S6 |
Study Chair: | Avraham Eisbruch, MD | University of Michigan Cancer Center |
Study ID Numbers: | CDR0000068231, RTOG-0022, RTOG-H-0022, RTOG-DEV-1065 |
Study First Received: | October 4, 2000 |
Last Updated: | October 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00006360 |
Health Authority: | United States: Federal Government |
stage II squamous cell carcinoma of the oropharynx stage III squamous cell carcinoma of the oropharynx radiation toxicity |
Epidermoid carcinoma Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Squamous cell carcinoma Head and Neck Neoplasms Carcinoma, squamous cell |
Pharyngeal Neoplasms Stomatognathic Diseases Carcinoma, Squamous Cell Pharyngeal Diseases Oropharyngeal Neoplasms Carcinoma |
Neoplasms Neoplasms by Site |