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Sponsored by: |
National Institute of Environmental Health Sciences (NIEHS) |
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Information provided by: | National Institute of Environmental Health Sciences (NIEHS) |
ClinicalTrials.gov Identifier: | NCT00044369 |
Varicose veins in the scrotum (varicocele) are responsible for >20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability. Surgical repair or removal of varicocele restores fertility in only 1/3 of cases. The goal of this study is to identify markers that predict the outcome of variocele correction. This would offer considerable health cost savings.
Based on preliminary findings, we will obtain testis biopsies and semen specimens from infertile men with varicocele and prospectively examining the levels of cadmium, a toxic metal, and expression of genes required for normal sperm function. The semen and biopsies will be obtained during clinically dictated procedures. Cadmium and gene expression will be compared with response to varicocele repair (i.e., increased sperm production; pregnancy).
Condition | Intervention |
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Varicocele Male Infertility Hypospermatogenesis Non-Obstructive Azoospermia |
Procedure: Varicocele repair |
Study Type: | Observational |
Study Design: | Screening, Longitudinal, Defined Population, Prospective Study |
Official Title: | Increased Testicular Cd2+ & Infertility With Varicocele ( a Varicose Vein in the Scrotum) |
Ages Eligible for Study: | 21 Years to 55 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
United States, New Jersey | |
University of Medicine and Dentistry of NJ, Robert Wood Johnson Medical School at Camden | |
Camden, New Jersey, United States, 08103 | |
United States, New York | |
North Shore University Hospital | |
Manhasset, New York, United States, 11030 |
Principal Investigator: | Susan H Benoff, PhD | North Shore University Hospital |
Study ID Numbers: | 10496-CP-001 |
Study First Received: | August 27, 2002 |
Last Updated: | September 1, 2006 |
ClinicalTrials.gov Identifier: | NCT00044369 |
Health Authority: | United States: Federal Government |
Varicocele environmental toxins male infertility cadmium |
Genital Diseases, Female Oligospermia Infertility Azoospermia Varicocele |
Varicose Veins Infertility, Male Vascular Diseases Genital Diseases, Male |
Cardiovascular Diseases |