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NIDA Home > Publications > Research Reports > Tobacco Addiction

Research Report Series - Tobacco Addiction


Where can I get further scientific information about tobacco addiction?



To learn more about tobacco and other drugs of abuse, visit the National Institute on Drug Abuse Web site at www.drugabuse.gov or call the National Clearinghouse for Alcohol and Drug Information at 800–729–6686.

Materials on the health effects of cigarettes and tobacco products and other drug abuse topics are available on the NIDA Web site (www.drugabuse.gov), and can be ordered free of charge in English and Spanish from NCADI at ncadi.samhsa.gov.

Nicotine and tobacco information can be accessed also through these other Web sites:



Glossary



Addiction: A chronic, relapsing disease characterized by compulsive drug seeking and abuse and by long-lasting neurochemical and molecular changes in the brain.

Adrenal glands: Glands located above each kidney that secrete hormones, e.g., adrenaline.

Craving: A powerful, often uncontrollable desire for drugs.

Dopamine: A neurotransmitter present in regions of the brain that regulate movement, emotion, motivation, and feelings of pleasure.

Emphysema: A lung disease in which tissue deterioration results in increased air retention and reduced exchange of gases. The result is difficulty breathing and shortness of breath.

Hyperglycemic: The presence of an abnormally high concentration of glucose in the blood.

Neurotransmitter: A chemical that acts as a messenger to carry signals or information from one nerve cell to another.

Nicotine: An alkaloid derived from the tobacco plant that is responsible for smoking’s psychoactive and addictive effects.

Pharmacokinetics: The pattern of absorption, distribution, and excretion of a drug over time.

Rush: A surge of euphoria that rapidly follows administration of some drugs.

Tobacco: A plant widely cultivated for its leaves, which are used primarily for smoking; the N. tabacum species is the major source of tobacco products.

Withdrawal: A variety of symptoms that occur after chronic use of an addictive drug is reduced or stopped.


References


1Substance Abuse and Mental Health Services Administration. Results from the 2004 National Survey on Drug Use and Health: National Findings. DHHS Pub. No. SMA 05-4062, 2005.

2Giovino GA, Henningfield JE, Tomar SL, Escobedo LG, Slade J. Epidemiology of tobacco use and dependence. Epidemiol Rev 17(1):48–65, 1995.

3National Institute on Drug Abuse. Monitoring the Future, National Results on Adolescent Drug Use, Overview of Key Findings 2005. NIH Pub. No. 01-4923, 2005.

4Lasser K, Boyd JW, Woolhandler S, Himmelstein DU, McCormick D, Bor DH. Smoking and mental illness. A population-based prevalence study. JAMA 284:2606–2610, 2000.

5Breslau N. Psychiatric comorbidity of smoking and nicotine dependence. Behav Genet 25:95–101, 1995.

6Hughes JR, Hatsukami DK, Mitchell JE, and Dahlgren LA. Prevalence of smoking among psychiatric outpatients. American Journal of Psychiatry 143:993-997, 1986.

7U.S. Department of Health and Human Services. The Health Consequences of Smoking: A Report of the Surgeon General. Atlanta, Georgia: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2004.

8Federal Trade Commission. "Tar," nicotine, and carbon monoxide of the smoke of 1294 varieties of domestic cigarettes for the year 1998. Federal Trade Commission, 2000.

9Benowitz NL. Pharmacology of nicotine: addiction and therapeutics. Ann Rev Pharmacol Toxicol 36:597–613, 1996.

10Bornemisza P, Suciu I. Effect of cigarette smoking on the blood glucose level in normals and diabetics. Med Interne 18 :353-6, 1980.

11U.S. Department of Health and Human Services. Reducing Tobacco Use: A Report of the Surgeon General. Atlanta, Georgia: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2000.

12Henningfield JE. Nicotine medications for smoking cessation. New Engl J Med 333:1196–1203, 1995.

13Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, MacGregor R, Alexoff D, Shea C, Schlyer D, Wolf AP, Warner D, Zezulkova I, Cilento R. Inhibition of monoamine oxidase B in the brains of smokers. Nature 22:733–736, 1996.

14Belluzzi JD, Wang R, Leslie FM. Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats. Neuropsychopharmacology 30:705–712, 2005.

15Centers for Disease Control and Prevention (CDC). Morbidity and Mortality Weekly Report (MMWR) 54(25):625–628, 2005.

16U.S. Department of Health and Human Services. Reducing the Health Consequences of Smoking. Atlanta, Georgia: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 1989.

17Centers for Disease Control and Prevention (CDC). Morbidity and Mortality Weekly Report (MMWR) 31(7):77–80, 1982.

18American Cancer Society. Cancer Facts and Figures, 2005. http://www.cancer.org/downloads/STT/CAFF2005f4PWSecured.pdf

19Riordan M, Rylance G, Berry K. Poisoning in children 5: rare and dangerous poisons. Arch Dis Child 87:407-10, 2002.

20Centers for Disease Control and Prevention (CDC). Morbidity and Mortality Weekly Report (MMWR) 51(14):300–303, 2002.

21Institute of Medicine (IOM). Clearing the smoke: assessing the science base for tobacco harm reduction, pp. 5, 2001.

22Stepanov I, Jensen J, Hatsukami D, Hecht SS. Tobacco-specific nitrosamines in new tobacco products. Nicotine Tob Res 8:309–313, 2006.

23Hatsukami DK, Lemmonds C, Zhang Y, Murphy SE, Le C, Carmella SG, Hecht SS. Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products. J Nat'l Cancer Inst. 96:844-52, 2004.

24Huizink AC, Mulder EJH. Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring. Neurosci and Biobehav Reviews 30:24-41, 2006.

25Adams EK, Miller VP, Ernst C, Nishimura BK, Melvin C, Merritt R. Neonatal health care costs related to smoking during pregnancy. Health Economics 11:193-206, 2002.

26Ernst M, Moolchan ET, Robinson ML. Behavioral and neural consequences of prenatal exposure to nicotine. J Am Acad Child Adolesc Psychiatry 40:630-641, 2001.

27Fried PA, Watkinson B, Gray R. Growth from birth to early adolescence in offspring prenatally exposed to cigarettes and marijuana. Neurotox Teratol 21:513-525, 1999.

28Law KL, Stroud LR, LaGasse LL, Niaura R, Liu J, Lester BM. Smoking during pregnancy and newborn neurobehavior. Pediatrics 111:1318-1323, 2003.

29Buka SL, Shenassa ED, Niaura R. Elevated risk of tobacco dependence among offspring of mothers who smoked during pregnancy: a 30-year prospective study. Am J Psychiatry 160:1978–1984, 2003.

30Perkins KA, Donny E, Caggiula AR. Sex differences in nicotine effects and self-administration: review of human and animal evidence. Nic and Tobacco Res 1:301-315, 1999.

31Perkins KA. Smoking cessation in women. Special Considerations. CNS Drugs 15:391-411, 2001.

32Perkins KA et al. Cognitive-behavioral therapy to reduce weight concerns improves smoking cessation outcome in weight-concerned women. J Consult Clin Psychol 69(4):604–613, 2001.

33Evins AE, Mays VK, Rigotti NA, Tisdale T, Cather C, Goff DC. A pilot trial of bupropion added to cognitive behavioral therapy for smoking cessation in schizophrenia. Nicotine Tob Res 3:397–403, 2001.

34O'Malley SS, Cooney JL, Krishnan-Sarin S, Dubin JA, McKee SA, Cooney NL, Blakeslee A, Meandzija B, Romano-Dahlgard D, Wu R, Makuch R, Jatlow P. A controlled trial of naltrexone augmentation of nicotine replacement therapy for smoking cessation. Arch Intern Med. 166:667-674, 2006.

35Centers for Disease Control and Prevention. Quick facts: economic and health burden of chronic disease. http://www.cdc.gov/nccdphp/press/index.htm.

36Levin ED, Rezvani AH, Montoya D, Rose JE, Swartzwelder HS. Adolescent-onset nicotine self-administration modeled in female rats. Psychopharmacol 169:141-149, 2003.

37U.S. Department of Health and Human Services. The Health Benefits of Smoking Cessation: A Report of the Surgeon General. Atlanta, Georgia: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 1990.

38Hall SM, Humfleet GL, Reus VI, Munoz RF, Cullen J. Extended nortriptyline and psychological treatment for cigarette smoking. Am J Psychiatry 161:2100-2107, 2004.

Index

Letter from the Director

What is the extent and impact of tobacco use?

How does tobacco deliver its effects?

Is nicotine addictive?

Are there other chemicals that may contribute to tobacco addiction?

What are the medical consequences of tobacco use?

Are there safe tobacco products?

Smoking and pregnancy—What are the risks?

Are there gender differences in tobacco smoking?

Smoking and adolescence

Are there effective treatments for tobacco addiction?

Where can I get further scientific information about tobacco addiction?

Glossary and References

Nicotine Addiction Research Report Cover


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