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Sponsors and Collaborators: |
New York University School of Medicine Doris Duke Charitable Foundation |
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Information provided by: | New York University School of Medicine |
ClinicalTrials.gov Identifier: | NCT00798122 |
Approximately 600,000 women are treated for acute coronary syndrome (ACS) annually in the US. ACS includes heart attack and a milder form called unstable angina. Many of these women have angiograms of which 14-39% show no "significant" coronary artery disease (CAD, cholesterol plaque accumulation in arteries of the heart). The remaining majority of women with ACS have cholesterol plaque buildup which appears severe enough on angiography to limit blood flow to the heart.
It is difficult to advise women with heart attacks and no major heart artery blockages on what to do if chest pain happens again. Additional studies are needed to find out why this sort of heart attack happens and to help doctors understand how to treat patients who have this problem in the best possible way.
Some women with heart attacks who have no major blockage in heart arteries have cholesterol plaque in the arteries of the heart cannot be seen on angiography but can be seen using a newer technique called intravascular ultrasound (IVUS). IVUS involves creating pictures of the artery walls using ultrasound (sound waves) from within the artery itself. In some women without major heart artery blockage, heart attack is caused by low blood flow due to disease of smaller blood vessels which cannot be seen on angiography or IVUS. This problem can be found using magnetic resonance imaging (MRI), which can show blood flow to the heart. MRI may also be used to show where the heart has been damaged. The pattern of damage could suggest that a heart attack in a woman, who has no badly blocked heart arteries, happened for one (or more) of these reasons or another reason.
The Study of Women with ACS and Non-obstructive CAD (SWAN) will use IVUS and MRI to help determine the reasons for heart attacks in women with no major blockages in heart arteries.
Condition | Intervention |
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Acute Coronary Syndromes |
Procedure: Intravascular ultrasound Procedure: MRI |
Study Type: | Interventional |
Study Design: | Diagnostic, Single Group Assignment |
Official Title: | Study of Women With Acute Coronary Syndromes and Nonobstructive Coronary Artery Disease |
Study Start Date: | March 2006 |
Estimated Study Completion Date: | February 2011 |
Estimated Primary Completion Date: | February 2011 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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Women: Experimental
IVUS and MRI performed in women with no obstructive CAD at angiography
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Procedure: Intravascular ultrasound
intravascular ultrasound
Procedure: MRI
cardiac MRI
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Ages Eligible for Study: | 21 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Harmony R Reynolds, MD | 212-263-6958 | harmony.reynolds@nyumc.org |
United States, New York | |
NYU Medical Center and Bellevue Hospital Center | Recruiting |
New York, New York, United States, 10016 | |
Principal Investigator: Harmony R Reynolds, MD | |
Sub-Investigator: Judith S Hochman, MD |
Responsible Party: | New York University School of Medicineq ( Harmony R. Reynolds, MD ) |
Study ID Numbers: | DD CSDA 2006066 |
Study First Received: | November 24, 2008 |
Last Updated: | November 24, 2008 |
ClinicalTrials.gov Identifier: | NCT00798122 |
Health Authority: | United States: Institutional Review Board |
sex acute coronary syndromes normal angiogram no obstruction at angiography women |
Arterial Occlusive Diseases Coronary Disease Heart Diseases Myocardial Ischemia Acute Coronary Syndrome |
Vascular Diseases Arteriosclerosis Ischemia Coronary Artery Disease |
Pathologic Processes Disease Syndrome Cardiovascular Diseases |