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Sponsors and Collaborators: |
University of Zurich Schweizerische Herzstiftung Eli Lilly and Company |
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Information provided by: | University of Zurich |
ClinicalTrials.gov Identifier: | NCT00126139 |
The purpose of the present prospective, randomized, double-blind, double dummy controlled multicenter pilot study is to investigate whether abciximab, compared with aspirin, is able to reduce the rate of recurrent ischemic strokes before and during carotid endarterectomy [CEA] (primary endpoints); and the degree of carotid stenosis, number of microembolic signal (MES) counts, number of ischemic infarcts at diffusion weighted imaging (DWI) and amount of intraluminal thrombus at pathological examination (secondary endpoints) in patients with ischemic stroke due to a >50% carotid stenosis who will undergo CEA.
Condition | Intervention | Phase |
---|---|---|
Stroke Stenosis |
Drug: Abciximab |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Active Control, Single Group Assignment, Safety/Efficacy Study |
Official Title: | Abciximab Versus Aspirin for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic >50% Carotid Stenosis: A Pilot Study (ASTERICS) |
Estimated Enrollment: | 100 |
Study Start Date: | April 2004 |
Study Completion Date: | May 2005 |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Switzerland | |
University of Zurich, Department of Neurology | |
Zurich, Switzerland, 8091 | |
University of Lausanne, Department of Neurology | |
Lausanne, Switzerland, 1011 | |
University of Bern, Department of Neurology | |
Bern, Switzerland, 3010 | |
University of Basel, Department of Neurology | |
Basel, Switzerland, 4031 | |
University of Geneva, Department of Neurology | |
Geneva, Switzerland, 1211 |
Study Chair: | Ralf W. Baumgartner, MD | University Hospital of Zurich, Department of Neurology, Switzerland |
Study ID Numbers: | E-046/2001 |
Study First Received: | July 29, 2005 |
Last Updated: | May 1, 2007 |
ClinicalTrials.gov Identifier: | NCT00126139 |
Health Authority: | Switzerland: Swissmedic |
stroke, ischemic stenosis, internal carotid artery Acute ischemic stroke Stenosis of extracranial internal carotid artery |
Pathological Conditions, Anatomical Arterial Occlusive Diseases Cerebral Infarction Stroke Vascular Diseases Abciximab Central Nervous System Diseases Constriction, Pathologic Ischemia |
Brain Diseases Cerebrovascular Disorders Recurrence Carotid Stenosis Aspirin Brain Ischemia Brain Infarction Infarction Carotid Artery Diseases |
Anticoagulants Therapeutic Uses Hematologic Agents Nervous System Diseases |
Platelet Aggregation Inhibitors Cardiovascular Diseases Pharmacologic Actions |