Phase II Trial of Pentostatin in Steroid Refractory Acute Graft Versus Host Disease

This study has been suspended.

Sponsored by:	Ohio State University Comprehensive Cancer Center
Information provided by:	Ohio State University Comprehensive Cancer Center
ClinicalTrials.gov Identifier:	NCT00201786

Purpose

This study will evaluate the response rate to treatment with pentostatin in steroid-refractory acute graft versus host disease.

Condition	Intervention	Phase
Graft-Versus-Host Disease	Drug: Pentostatin	Phase II

Drug Information available for: Corticosteroids Pentostatin

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study
Official Title:	Phase II Trial of Pentostatin in Steroid Refractory Acute Graft Versus Host Disease

Further study details as provided by Ohio State University Comprehensive Cancer Center:

Estimated Enrollment:	46
Study Start Date:	July 2003

Eligibility

Criteria

Inclusion Criteria:

Must have biopsy proven grade II-IV acute GVHD refractory to systemic corticosteroids
No chronic GVHD

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00201786

Locations

Sponsors and Collaborators

Ohio State University Comprehensive Cancer Center

Investigators

Principal Investigator:

Sherif Farag

Ohio State University

More Information

Study ID Numbers:	OSU-0301
Study First Received:	September 12, 2005
Last Updated:	June 27, 2007
ClinicalTrials.gov Identifier:	NCT00201786
Health Authority:	United States: Food and Drug Administration

Keywords provided by Ohio State University Comprehensive Cancer Center:

Corticosteroids

Study placed in the following topic categories:

Pentostatin
Graft versus host disease
Graft vs Host Disease
Homologous wasting disease

Additional relevant MeSH terms:

Molecular Mechanisms of Pharmacological Action
Immune System Diseases
Antineoplastic Agents

Therapeutic Uses
Enzyme Inhibitors
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 16, 2009